Thoracic epidural anesthesia in sepsis - is it harmful or protective?

Critical Care

Volumn 13, Issue 5, 2009, Pages

  Mutz, Christian ^a,b   Vagts, Dierk A ^a,b  

^a Department of Anaesthesiology and Intensive Care Medicine   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXEMIA; EPIDURAL ANESTHESIA; LUNG FUNCTION; NOTE; PRIORITY JOURNAL; SEPSIS; SYMPATHETIC TONE; THORAX EPIDURAL ANESTHESIA; CRITICAL ILLNESS; HUMAN; THORAX;

LOCAL ANESTHETIC AGENT;

ANESTHESIA, EPIDURAL; ANESTHETICS, LOCAL; CRITICAL ILLNESS; HUMANS; SEPSIS; THORAX;

EID: 77949910126     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc8015     Document Type: Note

References (15)

1. Freise H, Daudel F, Groszerichter C, Lauer S, Hinkelmann J, Van Aken HK, Sielenkaemper AW, Westphal M, Fischer LG. Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic rats. Crit Care 2009, 13:R116. 10.1186/cc7965, 19594914, 2750163.
2. Lauer S, Freise H, Westphal M, Zarbock A, Fobker M, Van Aken HK, Sielenkämper AW, Fischer LG. Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats. Crit Care 2009, 13:R109. 10.1186/cc7950, 19580652, 2750151.
3. Clemente A, Carli F. The physiological effects of thoracic epidural anaesthesia and analgesia on the cardiovascular, respiratory and gastrointestinal systems. Minerva Anesthesiol 2008, 74:549-563. 18854796.
4. Andrew PS, Kaufman S. Splenic denervatioin worsens lipopolysaccharide-induced hypotension, hemoconcentration, and hypovolemia. Am J Physiol Regul Integr Comp Physiol 2001, 280:R1564-1572.
5. Hershey JC, Bond RF. The influence of sympathoadrenal activation on skeletal muscle oxygen extraction during endotoxemia. Shock 1994, 1:115-122. 10.1097/00024382-199402000-00006, 7749929.
6. Schaller MD, Waeber B, Nussberger J, Brunner HR. Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxemia. Am J Physiol 1985, 249:H1086-1092.
7. Yang S, Koo DJ, Zhou M, Chaudry IH, Wang P. Gut-derived nor-epinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis. Am J Physiol Gastrointest Liver Physiol 2000, 279:G1274-1281.
8. Luchette FA, Robinson BR, Friend LA, McCarter F, Frame SB, James JH. Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. J Trauma 1999, 46:873-880. 10.1097/00005373-199905000-00017, 10338406.
9. Gelman S. General anesthesia and hepatic circulation. Can J Physiol Pharmacol 1987, 65:1762-1779.
10. Pastores SM, Katz DP, Kvetan V. Splanchnic ischemia and gut mucosal injury in sepsis and the multiple organ dysfunction syndrome. Am J Gastroenterol 1996, 91:1697-1710.
11. Fine J. Denervation of the splanchnic viscera for the treatment of shock. Am J Surg 1964, 107:723-724. 10.1016/0002-9610(64)90299-5, 14166207.
12. Rodgers A, Walker N, Schug S, McKee A, Kehlet H, van Zundet A, Sage D, Futter M, Saville G, Clark T, MacMahon S. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. Br Med J 2000, 321:1-12. 10.1136/bmj.321.7275.1493.
13. Popping DM, Elia N, Marret E, Remy C, Tramer MR. Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Arch Surg 2008, 143:990-999. 10.1001/archsurg.143.10.990, 18936379.
14. Vagts DA, Iber T, Roesner J, Mutz C, Flamann B, Nöldge-Schomburg G. Effects of epidural anaesthesia on splanchnic oxygenation during endotoxaemia. Intensive Care Med 2002, 28:S529.
15. Grassi G, Esler M. How to assess sympathetic activity in humans. J Hypertens 1999, 17:719-734. 10.1097/00004872-199917060-00001, 10459867.