CD26 expression in donor stem cell harvest and its correlation with engraftment in human haematopoietic stem cell transplantation: Potential predictor of early engraftment

Annals of Oncology

Volumn 21, Issue 3, 2009, Pages 582-588

  Prabhash, K ^a   Khattry, N ^a   Bakshi, A ^a   Karandikar, R ^a   Joshi, A ^a   Kannan, S ^a   Sastry, P S R K ^a   Parikh, P ^a   Kode, J A ^a  

^a TATA MEMORIAL HOSPITAL   (India)

Author keywords

CD26 expression; Flow cytometry; Haematopoietic stem cells; PBSC transplantation; Predictor of engraftment

Indexed keywords

CD34 ANTIGEN; DIPEPTIDYL PEPTIDASE IV; GRANULOCYTE COLONY STIMULATING FACTOR;

ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIGEN EXPRESSION; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BLOOD DONOR; CANCER PATIENT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; FLOW CYTOMETRY; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; MONOCYTE; NEUTROPHIL COUNT; PERIPHERAL BLOOD STEM CELL; PREDICTION; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ADULT; ANTIGENS, CD26; CHILD; FEMALE; FLOW CYTOMETRY; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKAPHERESIS; MALE; MIDDLE AGED; NEOPLASMS; SURVIVAL RATE; TISSUE DONORS; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77949902229     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdp342     Document Type: Article

References (20)

1. Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes. Diabetes Care 2007; 30: 1335-1341.
2. Durinx C, Lambeir AM, Bosmans E et al. Molecular characterization of dipeptidylpeptidase activity in serum: soluble CD26/dipeptidylpeptidase IV is responsible for the release of X-Pro dipeptides. Eur J Biochem 2000; 267: 5608-5613.
3. Vanham G, Kestens L, Demeester I et al. Decreased expression of the memory marker CD26 on both CD4+ and CD8+ T lymphocytes of HIV infected subjects. J Acquir Immune Defic Syndr 1993; 6: 749-757.
4. Kahne T, Lendeckel U, Wrenger S et al. Dipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review). Int J Mol Med 1999; 4: 3-15.
5. Busso N, Wagtmann N, Herling C et al. Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Am J Pathol 2005; 166: 433-442.
6. Christopherson KW II, Hangoc G, Mantel CR, Broxmeyer HE. Modulation of haematopoietic stem cell homing and engraftment by CD26. Science 2004; 305: 1000-1003.
7. Peranteau WH, Endo M, Adibe OO et al. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood 2006; 108: 4268-4274.
8. Christopherson KW II, Cooper S, Broxmeyer HE. Cell surface peptidase CD26 mediates G-CSF mobilization of mouse progenitor cells. Blood 2003; 101: 4680-4686.
9. Christopherson KW II, Cooper S, Hangoc G, Broxmeyer HE. CD26 is essential for normal G-CSF induced progenitor cells mobilization as determined by CD26-/-mice. Exp Haematol 2003; 31: 1126-1134.
10. Bonig H, Priestley GV, Oehler V, Papayannopoulou T. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Exp Haematol 2007; 35: 326-334.
11. Sutherland DR, Anderson L, Keeney M et al. The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering. J Hematother 1996; 5: 213-226.
12. Ohnuma K, Takahashi N, Yamochi T et al. Role of CD26/dipeptidyl peptidase IV in human T cell activation and function. Front Biosci 2008; 13: 2299-2310.
13. Christopherson KW II, Hangoc G, Broxmeyer HE. Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1amediated chemotaxis of human cord blood CD34+ progenitor cells. J Immunol 2002; 169: 7000-7008.
14. Christopherson KW II, Uralil SE, Porecha NK et al. G-CSF- and GM-CSF-induced upregulation of CD26 peptidase downregulates the functional chemotactic response of CD34+CD38- human cord blood hematopoietic cells. Exp Hematol 2006; 34: 1060-1068.
15. Petit I, Szyper-Kravitz M, Nagler A et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 2002; 3: 687-694.
16. Karl T, Chwalisz WT, Wedekind D et al. Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (dipeptidylpeptidase IV; CD26) gene in rats. Regul Pept 2003; 115: 81-90.
17. Yan S, Marguet D, Dobers J et al. Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen. Eur J Immunol 2003; 33: 1519-1527.
18. El Yacoubi M, Vaugeois JM, Marguet D et al. Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity. Behav Brain Res 2006; 171: 279-285.
19. Hicks C, Wong R, Manoharan A, Kwan YL. Viable CD34+/CD133+ blood progenitor cell dose as a predictor of haematopoietic engraftment in multiple myeloma patients undergoing autologous peripheral blood stem cell transplantation Ann Hematol 2007; 86: 591-598.
20. Orschell-Traycoff CM, Hiatt K, Dagher RN et al. Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycle Blood 2000; 96: 1380-1387.