Optimization of drug release from compressed multi unit particle system (MUPS) using generalized regression neural network (GRNN)

Archives of Pharmacal Research

Volumn 33, Issue 1, 2010, Pages 103-113

  Ivic, Branka ^a   Ibric, Svetlana ^b   Betz, Gabriele ^c   Zorica, Djuric ^b  

^a Galenika Ad   (Serbia)

^b Faculty of Pharmacy   (Serbia)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Carbopol 71G; Diclofenac sodium; Direct pelletization; Extended release; Matrix pellets; Multi unit particle system (MUPS)

Indexed keywords

CARBOMER; DICLOFENAC; PHOSPHATE BUFFERED SALINE;

ANALYTIC METHOD; ARTICLE; CONTROLLED DRUG RELEASE; CRUSHING STRENGTH; DRUG FORMULATION; DRUG PELLET; GENERALIZED REGRESSION NEURAL NETWORK; IN VITRO STUDY; POLYMERIZATION; PROCESS OPTIMIZATION; TABLET; TABLET COMPRESSION;

ACRYLATES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DICLOFENAC; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG DESIGN; EXCIPIENTS; HARDNESS; HUMIDITY; KINETICS; MICROSCOPY, ELECTRON, SCANNING; NEURAL NETWORKS (COMPUTER); PARTICLE SIZE; REGRESSION ANALYSIS; SOLUBILITY; TABLETS;

EID: 77949897807     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-2232-8     Document Type: Article

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