Do standard risk assessment procedures adequately account for cumulative risks?: An exploration of the possibilities using California's air toxics hot spots guidelines

International Journal of Toxicology

Volumn 29, Issue 1, 2010, Pages 65-70

  Salmon, Andrew G ^a  

^a CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cumulative; Exposure; Methods; Risk assessment

Indexed keywords

ACETALDEHYDE; ALCOHOL; NITROGEN DIOXIDE; OZONE; PERCHLORATE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; POLYCYCLIC AROMATIC HYDROCARBON; TERT BUTYL METHYL ETHER; TRICLOSAN;

AIR POLLUTION; CHEMICAL EXPOSURE; CONFERENCE PAPER; CUMULATIVE RISK; EXPOSURE; HEALTH HAZARD; RISK; RISK ASSESSMENT; AIR POLLUTANT; ARTICLE; CLASSIFICATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL PROTECTION; GOVERNMENT; HUMAN; LEGAL ASPECT; METHODOLOGY; PRACTICE GUIDELINE; TIME; UNITED STATES;

AIR POLLUTANTS; AIR POLLUTION; CALIFORNIA; CONSERVATION OF NATURAL RESOURCES; ENVIRONMENTAL EXPOSURE; GUIDELINES AS TOPIC; HUMANS; RISK ASSESSMENT; STATE GOVERNMENT; TIME FACTORS;

EID: 77949894320     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581809347803     Document Type: Conference Paper

References (16)

1. User's Guide for the Industrial Source Complex (ISC) Dispersion Models. Volumes I and II: User Instructions. Research Triangle Park, NC: US Environmental Protection Agency; 1995. EPA-454/B-95-003a.
2. Air toxics "hot spots" risk assessment guidelines: technical support document for the derivation of noncancer reference exposure levels. Office of Environmental Health Hazard Assessment, Cal/EPA. http://www.oehha.ca. gov/air/hot-spots/2008/NoncancerTSD-final.pdf. Published June 2008. Accessed September 1, 2009.
3. Air toxics "hot spots" risk assessment guidelines: technical support document for cancer potency factors. Office of Environmental Health Hazard Assessment, Cal/EPA. http://www.oehha.ca.gov/air/hot-spots/2009/ TSDCancerPotency.pdf. Published May 2009. Accessed September 1, 2009.
4. Air toxics "hot spots" risk assessment guidelines: technical support document for exposure assessment and stochastic analysis. Office of Environmental Health Hazard Assessment, Cal/EPA. http://www.oehha.ca.gov/air/ hot-spots/finalStoc.html#download. Published September 2000. Accessed September 1, 2009.
5. El-Masri HA. Experimental and mathematical modeling methods for the investigation of toxicological interactions. Toxicol Appl Pharmacol. 2007;223:148-154. (Pubitemid 47348052)
6. Lambert JC, Lipscomb JC. Mode of action as a determining factor in additivity models for chemical mixture risk assessment. Regul Toxicol Pharmacol. 2007;49:183-194.
7. Stoker TE, Ferrell JM, Laws SC, Cooper RL, Buckalew A. Evaluation of ammonium perchlorate in the endocrine disruptor screening and testing program's male pubertal protocol: ability to detect effects on thyroid endpoints. Toxicology. 2006;228:58-65. (Pubitemid 44566417)
8. Khan MA, Lichtensteiger CA, Faroon O, Mumtaz M, Schaeffer DJ, Hansen LG. The hypothalamo-pituitary-thyroid (HPT) axis: a target of nonpersistent ortho-substituted PCB congeners. Toxicol Sci. 2002;65:52-61. (Pubitemid 34092690)
9. Veldhoen N, Skirrow RC, Osachoff H, et al. The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development. Aquat Toxicol. 2006;80:217-227. (Pubitemid 44768034)
10. Potential health risks of ethanol in gasoline. Office of Environmental Health Hazard Assessment, Cal/EPA. http://www.oehha.ca.gov/air/etoh/ETOHfin2. html#download. Updated February 2000. Accessed September 1, 2009.
11. Interim Procedures for Estimating Risks Associated With Exposures to Mixtures of Chlorinated Dibenzo-p-Dioxins and -Dibenzofurans (CDDs and CDFs). Washington, DC: US Environmental Protection Agency, National Center for Environmental Assessment; 1987. EPA/625/3-87/012.
12. van den Berg M, Birnbaum LS, Denison M, et al. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci. 2006;93:223-241. (Pubitemid 44400442)
13. Collins JF, Brown JP, Alexeeff GV, Salmon AG. Potency equivalency factors for some polycyclic aromatic hydrocarbons and polycyclic aromatic hydrocarbon derivatives. Regul Toxicol Pharmacol. 1998;28:45-54.
14. Proposed identification of diesel exhaust as a toxic air contaminant. part B: health risk assessment for diesel exhaust, appendix G: quantitative cancer risk assessments based on rat lung tumor data and comparative potency analyses. Office of Environmental Health Hazard Assessment, Cal/EPA. ftp://ftp.arb.ca.gov/carbis/regact/diesltac/partb.pdf. Published May 1998. Accessed September 1, 2009.
15. Sauvain J-J, Vu Duc T, Guillemin M. Exposure to carcinogenic polycyclic aromatic compounds and health risk assessment for diesel-exhaust exposed workers. Int Arch Occup Environ Health. 2003;76:443-455. (Pubitemid 37038171)
16. Fowles J, Dybing E. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob Control. 2003;12:424-430. (Pubitemid 39452045)