Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins

Journal of Vascular Surgery

Volumn 51, Issue 4, 2010, Pages 962-971

  Raffetto, Joseph D ^a,b,c   Qiao, Xiaoying ^a   Beauregard, Katie G ^a   Tanbe, Alain F ^a   Kumar, Abhinav ^a   Mam, Virak ^a   Khalil, Raouf A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; PHENYLEPHRINE;

ADAPTATION; ADULT; ARTERY BYPASS; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; FEMALE; HUMAN; HUMAN TISSUE; MALE; MUSCLE ISOMETRIC CONTRACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAPHENOUS VEIN; VARICOSIS; VASCULAR SMOOTH MUSCLE; VEIN STRIPPING; VENOCONSTRICTION;

ADAPTATION, PHYSIOLOGICAL; AGED; ANGIOTENSIN II; CALCIUM SIGNALING; CASE-CONTROL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; POTASSIUM CHLORIDE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ADRENERGIC, ALPHA; SAPHENOUS VEIN; VARICOSE VEINS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 77949893231     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2009.11.037     Document Type: Article

References (30)

1. Raffetto J.D., and Khalil R.A. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology 23 (2008) 85-98
2. White J.V., and Ryjewski C. Chronic venous insufficiency. Perspect Vasc Surg Endovasc Ther 17 (2005) 319-327
3. Thulesius O., Said S., Shuhaiber H., Neglen P., and Gjores J.E. Endothelial mediated enhancement of noradrenaline induced vasoconstriction in normal and varicose veins. Clin Physiol 11 (1991) 153-159
4. Lowell R.C., Gloviczki P., and Miller V.M. In vitro evaluation of endothelial and smooth muscle function of primary varicose veins. J Vasc Surg 16 (1992) 679-686
5. Rizzi A., Quaglio D., Vasquez G., Mascoli F., Amadesi S., Calò G., et al. Effects of vasoactive agents in healthy and diseased human saphenous veins. J Vasc Surg 28 (1998) 855-861
6. Brunner F, Hoffmann C, Schuller-Petrovic S. Responsiveness of human varicose saphenous veins to vasoactive agents, Br J Clin Pharmacol 51 (2001) 219-224
7. Cotton L.T. Varicose veins. Gross anatomy and development. Br J Surg 48 (1961) 589-598
8. Alexander C.J. The theoretical basis of varicose vein formation. Med J Aust 1 (1972) 258-261
9. Kirsch D., Wahl W., Bottger T., and Junginger T. Primary varicose veins-changes in the venous wall and elastic behavior. Chirurg 71 (2000) 300-305
10. Parra J.R., Cambria R.A., Hower C.D., Dassow M.S., Freischlag J.A., Seabrook G.R., et al. Tissue inhibitor of metalloproteinase-1 is increased in the saphenofemoral junction of patients with varices in the leg. J Vasc Surg 28 (1998) 669-675
11. + channels: relevance to varicose vein formation. J Vasc Surg 45 (2007) 373-380
12. Raffetto J.D., Qiao X., Koledova V.V., and Khalil R.A. Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins. J Vasc Surg 48 (2008) 447-456
13. Sharony R., Grossi E.A., Saunders P.C., Schwartz C.F., Ribakove G.H., Culliford A.T., Ursomanno P., Baumann F.G., Galloway A.C., and Colvin S.B. Minimally invasive aortic valve surgery in the elderly: a case-control study. Circulation 108 suppl 1 (2003) II43-II47
14. Owens W.D., Felts J.A., and Spitznagel Jr. E.L. ASA physical status classifications: a study of consistency of ratings. Anesthesiology 49 (1978) 239-243
15. Eklöf B., Rutherford R.B., Bergan J.J., et al. ; American Venous Forum International Ad Hoc Committee for Revision of the CEAP Classification. Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 40 (2004) 1248-1252
16. Ryan M.J., Didion S.P., Mathur S., Faraci F.M., and Sigmund C.D. Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension 43 (2004) 1074-1079
17. Touyz R.M. Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II. Exp Physiol 90 (2005) 449-455
18. Siddiqui A.H., and Hussain T. Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats. Am J Physiol Heart Circ Physiol 292 (2007) H1722-H1727
19. Mehta P.K., and Griendling K.K. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 292 (2007) C82-C97
20. Stennett A.K., Qiao X., Falone A.E., Koledova V.V., and Khalil R.A. Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats. Am J Physiol Heart Circ Physiol 296 (2009) H745-H755
21. Gandhi R.H., Irizarry E., Nackman G.B., Halpern V.J., Mulcare R.J., and Tilson M.D. Analysis of the connective tissue matrix and proteolytic activity of primary varicose veins. J Vasc Surg 18 (1993) 814-820
22. Labropoulos N., Giannoukas A.D., Delis K., Mansour M.A., Kang S.S., Nicolaides A.N., et al. Where does venous reflux start?. J Vasc Surg 26 (1997) 736-742
23. Khalil R.A., and van Breemen C. Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation?. J Pharmacol Exp Ther 244 (1988) 537-542
24. Salamanca D.A., and Khalil R.A. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol 70 (2005) 1537-1547
25. Alexander R.W., Brock T.A., Gimbrone Jr. M.A., and Rittenhouse S.E. Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle. Hypertension 7 3 Pt 1 (1985) 447-451
26. Touyz R.M., and Schiffrin E.L. Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats. J Hypertens 15 12 Pt 1 (1997) 1431-1439
27. 2+ mobilization in saphenous vein smooth muscle cells derived from patients with primary varicosity. Eur J Clin Invest 32 (2002) 649-656
28. 2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol 26 (1999) 707-715
29. Ducasse E., Giannakakis K., Chevalier J., Dasnoy D., Puppinck P., Speziale F., et al. Dysregulated apoptosis in primary varicose veins. Eur J Vasc Endovasc Surg 29 (2005) 316-323
30. Schuller-Petrovic S., Siedler S., Kern T., Meinhart J., Schmidt K., and Brunner F. Imbalance between the endothelial cell-derived contracting factors prostacyclin and angiotensin II and nitric oxide/cyclic GMP in human primary varicosis. Br J Pharmacol 122 (1997) 772-778