Genotoxic risks for population in vicinity of traffic communication caused by PAHs emissions

WSEAS Transactions on Environment and Development

Volumn 6, Issue 3, 2010, Pages 198-207

  Bozek, Frantisek ^a   Adamec, Vladimir ^b   Navratil, Josef ^a   Kellner, Josef ^a   Bumbova, Alena ^a   Dvorak, Jiri ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b CDV TRANSPORT RESEARCH CENTRE   (Czech Republic)

Author keywords

Air; Contamination; Excess lifetime cancer risk (ELCR); Exposure scenarios; Genotoxic risk; Health; Lifetime average daily dose (LADD); Particulate matters (PM); Polycyclic aromatic hydrocarbons (PAHs); Traffic

Indexed keywords

ATMOSPHERIC POLLUTION; CANCER; CARCINOGEN; CONCENTRATION (COMPOSITION); GAS CHROMATOGRAPHY; GENOTOXICITY; HEALTH RISK; IMMUNE SYSTEM; PAH; PARTICULATE MATTER; PUBLIC HEALTH; RISK ASSESSMENT; ROADSIDE ENVIRONMENT; TRAFFIC EMISSION;

EID: 77949891669     PISSN: 17905079     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Adamec, V. et al. Traffic, Health and the Environment. 1st Ed. Praha: Grada Publishing, 2008, pp. 57-74. ISBN 978-80-247-2156-9.
2. Rutter, J. C. et al. Public Transport and Car Use in Developing Country: Energy and Management Issues, Indian Journal of Transport Management, Vol.21, No. 1, 1997, pp. 89-96.
3. Rutter, J. C. et al. Public Transport and car use in Developing Cities: Energy and Environment Issues, Indian Journal of Transport Management, Vol.21, No.2, 1997, pp. 141-178.
4. Isidori, M. et al. In situ Monitoring of Urban Air in Southern Italy with the Tradescantia Micronucleus Bioassays and Semipermeable Membrane Devices (SPMDs), Chemosphere, Vol.52, 2003, pp. 121-126.
5. Radakovic, B., Krope, T. The Effect of Ambient Air Pollution on Human Health. In Proceedings of the 2nd IASME/WSEAS International Conference on Energy & Environment. Portoroz: WSEAS, 2007, pp. 253-256. ISBN 978-960-8457-62-1.
6. Cerdeira, R. et al. Seasonality and Air Quality Effect in Health. In Proceedings of the 5th WSEAS International Conference on Environment, Ecosystems and Development. Venice: WSEAS, 2006, p. 355-362. ISBN 960-8457-56-4.
7. Iyer, G. V., Mastorakis, N. E. Environmental Health Effects of Chromium - A Modelling Approach to Find Environmental Impacts. In Proceedings of the 2006 IASME/WSEAS International Conference on Energy & Environmental Systems. Chalkida: WSEAS, 2006, pp. 430-439. ISBN 960-8457-44-0.
8. Adamec, V. Security Risks of Traffic, Possibilities of Reducing the Consequences and Prevention. [Habilitation thesis]. Ostrava: VSB, Technical University of Ostrava, 2006, pp. 41-42.
9. Benner, B. A., Gordon, G. E., Wise, S. A. Mobile Sources of Atmospheric Polycyclic Aromatic Hydrocarbons: A Roadway Tunnel Study, Environ. Sci. Technol., Vol.23, 1989, pp. 1269-1278.
10. Marr, L. C. et al. Vehicle Traffic as a Source of Particulate Polycyclic Aromatic Hydrocarbon Exposure in the Mexico City Metropolitan Area, Environ. Sci. Technol., Vol.38, No.9, 2004, pp. 2584-2592.
11. Pitts, J. N. et al. Atmospheric Reactions of PAH: Facile Formation of Mutagenic Nitro Derivatives, Sciences, Vol.202, 1978, pp. 515-519.
12. Sheu, H. L. et al. Particle-Bound Polycyclic Aromatic Hydrocarbon Content in Ambient Air, Environmental Pollution, Vol.96, No.3, 1997, pp. 369-382.
13. Venkatamaran, C., Friedlander, S. K. Size Distribution of PAH and Elemental Carbon, Environ. Sci. Technol., Vol.28, 1994, pp. 555-572.
14. Alves, C. A., Pio, C. A. Duarte, A. C. Particle Size Distributed Organic Compounds in a Forest Atmosphere, Environ. Sci. Technol., Vol.34, 2000, pp. 4287-4293.
15. Nicholson, K.W. A review of Particle Resuspension, Atmos. Environ., Vol.22, 1988, pp. 2639-2651.
16. Dockery, D. W., Pope, C. A. Acute Respiratory Effects of Particular Air Pollution, Annual Rev. Publ. Health, Vol.15, 1994, pp. 107-132.
17. Peters, A. et al. Associations between Mortality and Air Pollution in Central Europe, Environ. Health Perspect., Vol.108, 2000, pp. 283-287.
18. nd WSEAS International Conference on Computer Engineering and Applications. Acapulco: WSEAS, 2008, pp. 256-260. ISBN 978-960-6766-33-6.
19. Dockery, D. W. et al. An Association between Air Pollution and mortality in six U.S. Cities, New. Engl. J. Med., Vol.329, 1993, pp. 1753-1759.
20. Hoek, G. et al. Association between Mortality and Indicator of Trafic-Related Air Pollution in the Netherlands: A Cohort Study, Lancet, Vol.360, 2002, pp. 1203-1209.
21. International Agency for Research on Cancer (IARC). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Suppl. 4, Vols. 1 to 29. Chemicals, Industrial Processes, and Industries Associated with Cancer in Humans. Lyon: IARC, 1982, pp. 4-10.
22. U.S. EPA. Guidelines for Carcinogen Risk Assessment. Washington, DC: U.S. EPA, 1986.
23. Pott, F., Stöber, W. Carcinogenicity of Airborne Combustion Products observed in Subcutaneous Tissue and Lungs of Laboratory Rodents, Environ. Health Perspect., Vol.47, 1983, pp. 293-303.
24. Holoubek, I. Polycyclic Aromatic Hydrocarbons (PAHs) in the Environment. 1st Ed. Prague: The Czech Ecological Institute, 1996. 136 p. ISBN 80-85087-44-8.
25. Murray, R. K. et al. Harper's Biochemistry, 23rd Ed. Connecticut: Appleton & Lange 1993, pp. 743-748.
26. Hermann, M. Synergistic Effects of Individual Polycyclic Aromatic Hydrocarbons on the Mutagenicity of Their Mixtures, Mutat. Res., Vol.90, No.4, 1981, pp. 399-409.
27. Vakharia, D. D. et al. Polycyclic Aromatic Hydrocarbon/Metal Mixtures: Effect on PAH Induction of CYP1A1 in Human HepG2 Cells, Drug Metabolism and Disposition, Vol.29, No.7, 2001, pp. 999-1006.
28. Ministry of Environment (MoE). MoE Methodical Instructions No 12 for the Risk Analysis of Contaminated Area. MoE Bulletin, Vol. XV, article 9, 2005.
29. U.S. EPA. Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons. Report No. USEPA/600/R-93/089. Washington DC.: U.S. EPA Office of Research and Development, 1993.
30. U.S. EPA. Integrated Risk Information System. Database of Toxicological Parameters for Human Health. [on line]. [2006-05-14]. URL: .
31. Wisconsin Department of Natural Resources (WDNR). Soil Cleanup Levels for Polycyclic Aromatic Hydrocarbons. Interim Guidance. Madison: WDNR, 1997.
32. ] U.S. EPA Health Effects Assessment Summary Tables. Washington, DC: U.S. EPA, 1992.
33. U.S. EPA. Risk Assessment Guidance for Superfund: Vol. 1-Human Health Evaluation Manual. Interim Final. EPA/540/1-89/002, Washington, DC: U.S. EPA, 1989.
34. Nisbet, I. T. C., LaGoy, P. K. Toxic equivalency factors for Polycyclic Aromatic Hydrocarbons, Regulatory Toxicology and Pharmacology, Vol.16, 1992, pp. 290-300.
35. Peters, C. A., Knightes, Ch., Brown, D. Long-Term Composition Dynamics of Polycyclic Aromatic Hydrocarbons Containing NAPLs and Implications for Risk Assessment, Environ. Sci. Technol., Vol.33, 1999, pp. 4499-4507.
36. Office of Environmental Health Hazard Assessment. Hot Spots Unit Risk and Cancer Potency Values. 1999.
37. Topinka, J. Rat Hepatocytes like a Relevant Model in Genetic Toxicology. Prague: Academy of Sciences of the Czech Republic, 2004. 27 p.
38. Nesnow, S. et al. Lung Tumorigenic Interactions in Strain A/J Mice of Five Environmental Polycyclic Aromatic Hydrocarbons, Environ. Health Perspect., Vol.106, 1998, pp. 1337-1346.
39. Binkova, B., Sram, R. J. The Genotoxic Effect of Carcinogenic PAHs, Their Artificial and Environmental Mixtures (EOM) on Human Diploid Fibroblasts, Mutation. Res., Vol.547, 2004, pp. 109-121.
40. Lau, H. H., Baird, W. M. The Co-Carcinogen Benzo[e]pyrene Increases the Binding of a Low Dose of the Carcinogen Benzo[a]pyrene to DNA in Sencar Mouse Epidermis, Cancer Lett. Vol.63, 1992, pp. 229-236.
41. Staal, Y. M. C. et al. Binary PAH Mixtures Cause Additive or Antagonistic Effects on Gene Expression but Synergistic Effects on DNA Adduct Formation, Carcinogenesis, Vol.28, No.12, 2007, pp. 2632-2640.
42. Vione, D. Et al. Polycyclic Aromatic Hydrocarbons in the Atmosphere: Monitoring, Sources, Sinks and Fate, Annali di Chimica, Vol.94, No.4, 2004, pp. 257-268.