Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formation

Journal of Vascular Surgery

Volumn 51, Issue 4, 2010, Pages 951-961

  Eagleton, Matthew J ^a   Xu, Jun ^a   Liao, Mingfang ^b   Parine, Brittney ^a   Chisolm, Guy M ^a   Graham, Linda M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; APOLIPOPROTEIN E; MESSENGER RNA; PHOSPHOPROTEIN; STAT1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; AORTA DISSECTION; AORTA RUPTURE; ARTERY DIAMETER; ARTICLE; CONTROLLED STUDY; DEGENERATION; EXPERIMENTAL MODEL; FEMALE; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE;

AGED; ANALYSIS OF VARIANCE; ANEURYSM, DISSECTING; ANGIOTENSIN II; ANIMALS; AORTIC ANEURYSM, ABDOMINAL; AORTIC RUPTURE; APOLIPOPROTEINS E; CHI-SQUARE DISTRIBUTION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SEX FACTORS; STAT1 TRANSCRIPTION FACTOR; TIME FACTORS;

EID: 77949888545     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2009.11.075     Document Type: Article

References (31)

1. Davis V., Persidskaia R., Baca-Regen L., Itah Y., Nagase H., Persidsky Y., et al. Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 18 (1998) 1625-1633
2. Pyo R., Lee J., Shipley J., Curci J., Mao D., Ziporin S., et al. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 105 (2000) 1641-1649
3. Thompson R., and Parks W. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann NY Acad Sci 800 (1996) 157-174
4. Miyake T., Aoki M., Masaki H., Kawasaki T., Oishi M., Kataoka K., et al. Regression of abdominal aortic aneurysm by simultaneous inhibition of nuclear factor kB and ets in a rabbit model. Circ Res 101 (2007) 1175-1184
5. Nakashima H., Aoki M., Miyake T., Kawasaki T., Iwai M., Jo N., et al. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligonucleotides suppressing activity of nuclear factor kBand ets transcription factors. Circulation 109 (2004) 132-138
6. Levy D., and Darnell Jr. J. STATS: Transcriptional control and biological impact. Nature Rev 3 (2002) 651-662
7. Ihle J. The Stat family in cytokine signaling. Curr Opin Cell Biol 13 (2001) 211-217
8. Haura E., Turkson J., and Jove R. Mechansims of disease: insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Oncol 2 (2005) 315-324
9. Agrawal S., Febbraio M., Podrez E., Cathcart M., Stark G., and Chisolm G. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115 (2007) 2939-2947
10. Daugherty A., Manning M., and Cassis L. Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. Br J Pharmacol 134 (2001) 865-870
11. Eagleton M., Ballard N., Lynch E., Srivastava S., Upchurch G., and Stanely J. Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during angiotensin II induced aneurysm formation. J Surg Res 135 (2006) 345-351
12. Knipp B., Ailawadi G., Ford J., Peterson D., Eagleton M., Roelofs K., et al. Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is associated with increased nuclear factor-KB and activator protein-1 activity. J Surg Res 116 (2004) 70-80
13. Saraff K., Babamusta F., Cassis L.A., and Daugherty A. Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 23 (2003) 1621-1626
14. Absi T., Sundt III T., Tung W., Moon M., Lee J., Damiano R., et al. Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: Complementary DNA expression profiling in molecular characterization of aortic disease. J Thor Cardiovasc Surg 126 (2003) 344-357
15. Thompson R., Holmes D., Mertens R., Liao S., Botney M., Mecham R., et al. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. J Clin Invest 96 (1995) 318-326
16. Daugherty A., Manning M., and Cassis L. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105 (2000) 1605-1612
17. Daugherty A., and Cassis L. Chronic angiotensin II infusion promotes atherogenesis in low density lipoprotein receptor -/- mice. Ann NY Acad Sci 892 (1999) 108-118
18. Gupta S., Pablo A., Jiang X., Wang N., Tall A., and Schindler C. IFN-gamma potentiates atherosclerosis in ApoE-knockout mice. J Clin Invest 99 (1997) 2752-2761
19. Xiong W., Zhao Y., Prall A., Greiner T., and Baxter B. Key roles of CD4+ T cells and interferon gamma in the development of abdominal aortic aneurysms in a murine model. J Immunol 2004 (2009) 2607-2612
20. Shimizu K., Shichiri M., Libby P., Lee R., and Mitchell R. Th2-predominant inflammation and blockade of IFN gamma signaling induce aneurysm in allografted aortas. J Clin Invest 114 (2004) 168-171
21. Walters D., Antao-Menezes A., Ingram J., Rice A., Nyska A., Tani Y., et al. Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. Am J Pathol 167 (2005) 1221-1229
22. Johnston J., Jiang Y., van Marle G., Mayne M., Ni W., Holden J., et al. Lentivirus infection in the brain induces matrix metalloproteinase expression: role of envelope diversity. J Virol 74 (2000) 7211-7220
23. Huang S., Bucana C., Van Arsdall M., and Fidler I. Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells. Oncogene 21 (2002) 2504-2512
24. Hernandez-Vargas P., Lopez-Franco O., Sanjuan G., Ruperez M., Ortiz-Munoz G., Suzuki Y., et al. Suppressors of cytokine signaling regulate angiotensin II-activated Janus kinase-signal transducers and activators of transcription pathway in renal cells. J Am Soc Nephrol 16 (2005) 1673-1683
25. Banes-Berceli A., Shaw S., Ma G., Brands M., Eaton D., Stern D., et al. Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells. Am J Physiol Renal Physiol 291 (2006) F116-F121
26. Luchtefeld M., Grote K., Grothuse C., Bley S., Bandlow N., Selle T., et al. Angiotensin II induces MMP-2 in a p47phox-dependent manner. Biochem Biophys Res Comm 328 (2005) 183-188
27. Rouet-Benzineb P., Gontero B., Dreyfus P., and Lafuma C. Angiotensin II induces nuclear factor-KB activation in cultured neonatal rat cardiomyocytes through protein kinase C signaling pathway. J Mol Cell Cardiol 32 (2000) 1767-1778
28. Wang T.-L., Yang Y., Chang H., and Hung C. Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. J Mol Cell Cardiol 37 (2004) 785-794
29. Manning M.W., Cassis L.A., Huang J., Szilvassy S.J., and Daugherty A. Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease. Vasc Med 7 (2002) 45-54
30. Martin-McNulty B., Tham D., daCunha V., Ho J., Wilson D., Rutledge J., et al. 17B-estradiol attenuates development of angiotensin II induced abdominal aortic aneurysm in apolipoprotein E deficient mice. Arterioscler Thromb Vasc Biol 23 (2003) 1627-1632
31. Ailawadi G., Eliason J., Roelofs K., Sinha I., Hannawa K., Kaldjian E., et al. Gender differences in experimental aortic aneurysm formation. Arterioscler Thromb Vasc Biol 24 (2004) 2116-2122