Chronic intermittent hypobaric hypoxia decreases β-adrenoceptor activity in right ventricular papillary muscle

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 4, 2010, Pages

  Guan, Yue ^a   Gao, Lu ^a   Ma, Hui Jie ^a   Li, Qian ^a   Zhang, Hao ^a   Yuan, Fang ^a   Zhou, Zhao Nian ^b   Zhang, Yi ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

adrenergic receptor; Action potential; Contraction; G protein; Intermittent hypoxia

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; RADIOLIGAND;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR FUNCTION; CHRONIC INTERMITTENT HYPOBARIC HYPOXIA; CONTROLLED STUDY; HEART MUSCLE; HEART PAPILLARY MUSCLE; HEART RIGHT VENTRICLE; HYPOBARISM; INOTROPISM; MALE; MEMBRANE BINDING; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; ANOXIA; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEART VENTRICLES; ISOPROTERENOL; MALE; MODELS, ANIMAL; MUSCLE CONTRACTION; ORGAN SIZE; PAPILLARY MUSCLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA;

EID: 77949885205     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00410.2009     Document Type: Article

References (29)

1. Beguin PC, Belaidi E, Godin-Ribuot D, Levy P, Ribuot C. Intermittent hypoxia-induced delayed cardioprotection is mediated by PKC and triggered by p38 MAP kinase and Erk1/2. J Mol Cell Cardiol 42: 343-351, 2007.
2. Beguin PC, Joyeux-Faure M, Godin-Ribuot D, Levy P, Ribuot C. Acute intermittent hypoxia improves rat myocardium tolerance to ischemia. J Appl Physiol 99: 1064-1069, 2005.
3. Böhm M, Gierschik P, Knorr A, Larisch K, Weismann K, Erdmann E. Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats. J Hypertens 10: 1115-1128, 1992.
4. Catelli M, Feldman J, Bousquet P, Tibirica E. Protective effects of centrally acting sympathomodulatory drugs on myocardial ischemia induced by sympathetic overactivity in rabbits. Braz J Med Biol Res 36: 85-95, 2003.
5. Ding HL, Zhu HF, Dong JW, Zhu WZ, Yang WW, Yang HT, Zhou ZN. Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. Acta Pharmacol Sin 26: 315-322, 2005.
6. Ding HL, Zhu HF, Dong JW, Zhu WZ, Zhou ZN. Intermittent hypoxia protects the rat heart against ischemia/reperfusion injury by activating protein kinase C. Life Sci 75: 2587-2603, 2004.
7. Dong JW, Zhu HF, Zhu WZ, Ding HL, Ma TM, Zhou ZN. Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression. Cell Res 13: 385-391, 2003.
8. Germack R, Leon-Velarde F, Valdes De La Barra R, Farias J, Soto G, Richalet JP. Effect of intermittent hypoxia on cardiovascular function, adrenoceptors and muscarinic receptors in Wistar rats. Exp Physiol 87: 453-460, 2002.
9. s protein and adenylyl cyclase signaling in rats exposed to chronic hypoxia and normoxic recovery. J Appl Physiol 94: 2423-2432, 2003.
10. Hurtado A. Some clinical aspects of life at high altitudes. Ann Intern Med 53: 247-258, 1960.
11. Kacimi R, Moalic JM, Aldashev A, Vatner DE, Richalet JP, Crozatier B. Differential regulation of G protein expression in rat hearts exposed to chronic hypoxia. Am J Physiol Heart Circ Physiol 269: H1865-H1873, 1995.
12. Kacimi R, Richalet JP, Corsin A, Abousahl I, Crozatier B. Hypoxia-induced downregulation of β-adrenergic receptors in rat heart. J Appl Physiol 73: 1377-1382, 1992.
13. Leon-Velarde F, Bourin MC, Germack R, Mohammadi K, Crozatier B, Richalet JP. Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion. Am J Physiol Regul Integr Comp Physiol 280: R274-R281, 2001.
14. Li HT, Honbo NY, Karliner JS. Chronic hypoxia increases beta 1-adrenergic receptor mRNA and density but not signaling in neonatal rat cardiac myocytes. Circulation 94: 3303-3310, 1996.
15. Mader SL, Downing CL, Van Lunteren E. Effect of age and hypoxia on beta-adrenergic receptors in rat heart. J Appl Physiol 71: 2094-2098, 1991.
16. Mardon K, Merlet P, Syrota A, Maziere B. Effects of 5-day hypoxia on cardiac adrenergic neurotransmission in rats. J Appl Physiol 85: 890-897, 1998.
17. Nieto JL, Diaz-Laviada I, Guillen A, Garcia-Barreno P, Haro A. Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy. Cell Signal 5: 169-179, 1993.
18. sα and adenylyl cyclase cause β-adrenoceptor desensitization in chronically hypoxic rat hearts. Am J Physiol Cell Physiol 279: C1455-C1463, 2000.
19. Voelkel NF, Hegstrand L, Reeves JT, McMurty IF, Molinoff PB. Effects of hypoxia on density of β-adrenergic receptors. J Appl Physiol 50: 363-366, 1981.
20. Watson AM, Hood SG, May CN. Mechanisms of sympathetic activation in heart failure. Clin Exp Pharmacol Physiol 33: 1269-1274, 2006.
21. Zhang Y, Yang HT, Zhou ZN. The cardioprotection of intermittent hypoxic adaptation. Sheng Li Xue Bao 59: 601-613, 2007.
22. Zhang Y, Zhong N, Gia J, Zhou Z. Effects of chronic intermittent hypoxia on the hemodynamics of systemic circulation in rats. Jpn J Physiol 54: 171-174, 2004.
23. Zhang Y, Zhong N, Zhou ZN. Effects of intermittent hypoxia on action potential and contraction in non-ischemic and ischemic rat papillary muscle. Life Sci 67: 2465-2471, 2000.
24. Zhang Y, Zhong N, Zhu HF, Zhou ZN. Antiarrhythmic and antioxidative effects of intermittent hypoxia exposure on rat myocardium. Sheng Li Xue Bao 52: 89-92, 2000.
25. Zhong N, Zhang Y, Fang QZ, Zhou ZN. Intermittent hypoxia exposure-induced heat-shock protein 70 expression increases resistance of rat heart to ischemic injury. Acta Pharmacol Sin 21: 467-472, 2000.
26. Zhong N, Zhang Y, Zhu HF, Wang JC, Fang QZ, Zhou ZN. Myocardial capillary angiogenesis and coronary flow in ischemia tolerance rat by adaptation to intermittent high altitude hypoxia. Acta Pharmacol Sin 23: 305-310, 2002.
27. Zhu HF, Dong JW, Zhu WZ, Ding HL, Zhou ZN. ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury. Life Sci 73: 1275-1287, 2003.
28. Zhu WZ, Xie Y, Chen L, Yang HT, Zhou ZN. Intermittent high altitude hypoxia inhibits opening of mitochondrial permeability transition pores against reperfusion injury. J Mol Cell Cardiol 40: 96-106, 2006.
29. Zicha S, Tsuji Y, Shiroshita-Takeshita A, Nattel S. Beta-blockers as antiarrhythmic agents. Handb Exp Pharmacol 235-266, 2006.