Efficient computation of parameter sensitivities of discrete stochastic chemical reaction networks

Journal of Chemical Physics

Volumn 132, Issue 3, 2010, Pages

  Rathinam, Muruhan ^a   Sheppard, Patrick W ^b   Khammash, Mustafa ^b  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL NETWORK; COMMON RANDOM NUMBERS; COMMONLY USED; COUPLED REACTION; DISCRETE STATE; EFFICIENT COMPUTATION; FINITE DIFFERENCE; FINITE DIFFERENCE APPROXIMATIONS; INDISPENSABLE TOOLS; NETWORK PARAMETERS; NUMERICAL EVIDENCE; PARAMETER SENSITIVITIES; PARAMETRIC SENSITIVITY; POSITIVE CORRELATIONS; RANDOM NUMBERS; REACTION PATHS; SENSITIVITY ESTIMATION; SPEED-UP FACTORS; STOCHASTIC CHEMICAL REACTIONS; STOCHASTIC REPRESENTATIONS; STOCHASTIC SIMULATION ALGORITHMS; SYSTEM ROBUSTNESS; THEORETICAL BASIS; TIME CHANGE; VARIANCE REDUCTIONS;

COMPUTER SIMULATION; DRUG THERAPY; MARKOV PROCESSES; MONTE CARLO METHODS; NUMERICAL METHODS; SENSITIVITY ANALYSIS; STOCHASTIC MODELS; STOCHASTIC SYSTEMS;

PARAMETER ESTIMATION;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; CHEMICAL MODEL; COMPUTER SIMULATION; STATISTICS;

ALGORITHMS; COMPUTER SIMULATION; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, GENETIC; STOCHASTIC PROCESSES;

EID: 77949884150     PISSN: 00219606     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.3280166     Document Type: Article

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