Relations between toxicity and altered tissue distribution and urinary excretion of nicotine, cotinine, and hydroxycotinine after chronic oral administration of nicotine in rats

Drug and Chemical Toxicology

Volumn 33, Issue 2, 2010, Pages 166-172

  Kim, Ki Young ^a,b   Lee, Young Joo ^b   Chung, Bong Chul ^a   Hong, Jongki ^b   Jung, Byung Hwa ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Cotinine; Nicotine; Tissue distribution; Toxicity; Urinary excretion

Indexed keywords

ASPARTATE AMINOTRANSFERASE; COTININE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE ALPHA; HYDROXYCOTININE; NICOTINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; HISTOPATHOLOGY; LIVER TOXICITY; LOW DRUG DOSE; MALE; NEPHROTOXICITY; NONHUMAN; RAT; TISSUE DISTRIBUTION; TOXICOKINETICS; UREA NITROGEN BLOOD LEVEL; URINARY EXCRETION; WEIGHT REDUCTION;

ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD CHEMICAL ANALYSIS; BLOOD UREA NITROGEN; BRAIN; COTININE; GANGLIONIC STIMULANTS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE TRANSFERASE; KIDNEY; LIVER; MALE; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

RATTUS;

EID: 77949882361     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480540903196832     Document Type: Article

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