Cytokines levels, Severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer - a prospective pilot study

Radiation Oncology

Volumn 5, Issue 1, 2010, Pages

  Meirovitz, Amichay ^a   Kuten, Michal ^b   Billan, Salem ^c   Abdah Bortnyak, Roxolyana ^c   Sharon, Anat ^a   Peretz, Tamar ^a   Sela, Mordechai ^a   Schaffer, Moshe ^c   Barak, Vivian ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; CYTOKINE; DOCETAXEL; FLUOROURACIL; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC AGENT;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; DISEASE SEVERITY; DYSPHAGIA; FEMALE; HEAD AND NECK CANCER; HIGH RISK PATIENT; HUMAN; MALE; MUCOSA INFLAMMATION; PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; PILOT STUDY; PROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; ADOLESCENT; BLOOD; CANCER STAGING; ENTERIC FEEDING; HEAD AND NECK TUMOR; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; RADIOTHERAPY;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; CYTOKINES; ENTERAL NUTRITION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MUCOSITIS; NEOPLASM STAGING; PILOT PROJECTS; RADIOTHERAPY; YOUNG ADULT;

EID: 77949881048     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-5-16     Document Type: Article

References (27)

1. Wong PC, Dodd MJ, Miaskowski C, Paul SM, Bank KA, Shiba GH, Facione N. Mucositis pain induced by radiation therapy: prevalence, severity, and use of self-care behaviors. J Pain Symptom Manage 2006, 32:27-37. 10.1016/j.jpainsymman.2005.12.020, 16824982.
2. Scully C, Epstein J, Sonis S. Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis. Head Neck 2003, 25:1057-1070. 10.1002/hed.10318, 14648865.
3. Alden ME, O'Reilly RC, Topham A, Lowry LD, Brodovsky H, Curran WJ. Elapsed radiation therapy treatment time as a predictor of survival in patients with advanced head and neck cancer who receive chemotherapy and radiation therapy. Radiology 1996, 201:675-680.
4. Wood K. Audit of nutritional guidelines for head and neck cancer patients undergoing radiotherapy. J Hum Nutr Diet 2005, 18:343-351. 10.1111/j.1365-277X.2005.00632.x, 16150130.
5. Peterman A, Cella D, Glandon G, Dobrez D, Yount S. Mucositis in head and neck cancer: economic and quality-of-life outcomes. J Natl Cancer Inst Monogr 2001, 45-51.
6. Whicher JT, Evans SW. Cytokines in disease. Clin Chem 1990, 36:1269-1281.
7. Barak V, Kalickman I, Nisman B, Farbstein H, Fridlender ZG, Baider L, Kaplan A, Stephanos S, Peretz T. Changes in cytokine production of breast cancer patients treated with interferons. Cytokine 1998, 10:977-983. 10.1006/cyto.1998.0378, 10049522.
8. Chen Z, Malhotra PS, Thomas GR, Ondrey FG, Duffey DC, Smith CW, Enamorado I, Yeh NT, Kroog GS, Rudy S, McCullagh L, Mousa S, Quezado M, Herscher LL, Van Waes C. Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res 1999, 5:1369-1379.
9. Kanazawa T, Nishino H, Hasegawa M, Ohta Y, Iino Y, Ichimura K, Noda Y. Interleukin-6 directly influences proliferation and invasion potential of head and neck cancer cells. Eur Arch Otorhinolaryngol 2007, 264:815-821. 10.1007/s00405-007-0264-6, 17310346.
10. Heikkila K, Ebrahim S, Lawlor DA. Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur J Cancer 2008, 44:937-945. 10.1016/j.ejca.2008.02.047, 18387296.
11. Gokhale AS, Haddad RI, Cavacini LA, Wirth L, Weeks L, Hallar M, Faucher J, Posner MR. Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck. Oral Oncol 2005, 41:70-76. 10.1016/j.oraloncology.2004.06.005, 15598588.
12. Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M, . European Organization for Research and Treatment of Cancer Trial 22931 Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004, 350:1945-1952. 10.1056/NEJMoa032641, 15128894, European Organization for Research and Treatment of Cancer Trial 22931.
13. Cooper JS, Bernier J. Rationale for triage in the postoperative management of head and neck cancers. Oncology 2005, 19:1011-1017.
14. Vissink A, Jansma J, Spijkervet FK, Burlage FR, Coppes RP. Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med 2003, 14:199-212. 10.1177/154411130301400305, 12799323.
15. Sciubba JJ, Goldenberg D. Oral complications of radiotherapy. Lancet Oncol 2006, 7:175-183. 10.1016/S1470-2045(06)70580-0, 16455482.
16. Druzgal CH, Chen Z, Yeh NT, Thomas GR, Ondrey FG, Duffey DC, Vilela RJ, Ende K, McCullagh L, Rudy SF, Muir C, Herscher LL, Morris JC, Albert PS, Van Waes C. A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma. Head Neck 2005, 27:771-784. 10.1002/hed.20246, 15920746.
17. Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol 2004, 22:929-979. 10.1146/annurev.immunol.22.012703.104622, 15032600.
18. Akmansu M, Unsal D, Bora H, Elbeg S. Influence of locoregional radiation treatment on tumor necrosis factor-alpha and interleukin-6 in the serum of patients with head and neck cancer. Cytokine 2005, 31:41-45. 10.1016/j.cyto.2005.02.009, 15878671.
19. Xanthinaki A, Nicolatou-Galitis O, Athanassiadou P, Gonidi M, Kouloulias V, Sotiropoulou-Lontou A, Pissakas G, Kyprianou K, Kouvaris J, Patsouris E. Apoptotic and inflammation markers in oral mucositis in head and neck cancer patients receiving radiotherapy: preliminary report. Support Care Cancer 2008, 16:1025-1033. 10.1007/s00520-007-0379-8, 18197435.
20. Dinarello CA. Biology of interleukin 1. FASEB J 1988, 2:108-115.
21. Hart JP, Broadwater G, Rabbani Z, Moeller BJ, Clough R, Huang D, Sempowski GA, Dewhirst M, Pizzo SV, Vujaskovic Z, Anscher MS. Cytokine profiling for prediction of symptomatic radiation-induced lung injury. Int J Radiat Oncol Biol Phys 2005, 63:1448-1454. 10.1016/j.ijrobp.2005.05.032, 16115739.
22. Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005, 41:2502-2012. 10.1016/j.ejca.2005.08.016, 16199153.
23. Woods KV, El-Naggar A, Clayman GL, Grimm EA. Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens. Cancer Res 1998, 58:3132-3141.
24. Nishino H, Miyata M, Kitamura K. The effect of interleukin-6 on enhancing the invasiveness of head and neck cancer cells in vitro. Eur Arch Otorhinolaryngol 1998, 255:468-472. 10.1007/s004050050101, 9833216.
25. Duffy SA, Taylor JM, Terrell JE, Islam M, Li Y, Fowler KE, Wolf GT, Teknos TN. Interleukin-6 predicts recurrence and survival among head and neck cancer patients. Cancer 2008, 113:750-757. 10.1002/cncr.23615, 18536030.
26. Haddad R, Sonis S, Posner M, Wirth L, Costello R, Braschayko P, Allen A, Mahadevan A, Flynn J, Burke E, Li Y, Tishler RB. Randomized Phase 2 Study of Concomitant Chemoradiotherapy Using Weekly Carboplatin/Paclitaxel With or Without Daily Subcutaneous Amifostine in Patients With Locally Advanced Head and Neck Cancer. Cancer 2009, 115:4514-23. 10.1002/cncr.24525, 19634161.
27. Vairaktaris E, Yapijakis C, Serefoglou Z, Avgoustidis D, Critselis E, Spyridonidou S, Vylliotis A, Derka S, Vassiliou S, Nkenke E, Patsouris E. Gene expression polymorphisms of interleukins-1b, -4, -6, -8, -10, and tumor necrosis factors-a, -b: regression analysis of their effect upon oral squamous cell carcinoma. J Cancer Res Clin Oncol 2008, 134:821-832. 10.1007/s00432-008-0360-z, 18273643.