Marginal maternal Zn intake in rats alters mammary gland Cu transporter levels and milk Cu concentration and affects neonatal Cu metabolism

Journal of Nutrition

Volumn 133, Issue 7, 2003, Pages 2141-2148

  Kelleher, Shannon L ^a   Lönnerdal, Bo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Copper transport; Lactation; Mammary gland; Zinc deficiency

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BIOLOGICAL MARKER; CARRIER PROTEIN; CERULOPLASMIN; COPPER; MENKES COPPER ADENOSINE TRIPHOSPHATASE; PROTEIN; PROTEIN CTR1; UNCLASSIFIED DRUG; WILSON COPPER ADENOSINE TRIPHOSPHATASE; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPPER BLOOD LEVEL; COPPER METABOLISM; DIET; IMMUNOHISTOCHEMISTRY; MAMMARY GLAND FUNCTION; MILK LEVEL; NEWBORN; NONHUMAN; PREGNANCY; PROGENY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SUCKLING; TISSUE LEVEL; ZINC DEFICIENCY;

ANIMALIA;

EID: 0038606363     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.7.2141     Document Type: Article

References (39)

1. King, J. C. (2002) Enhanced zinc utilization during lactation may reduce maternal and infant zinc depletion. Am. J. Clin. Nutr. 75: 2-3.
2. Castilo-Duran, C. & Cassorla, F. (1999) Trace minerals in human growth and development, J. Pediatr. Endocrinol. Metab. 12: 589-601.
3. Linder, M. C., Wooten, L., Cerveza, P., Cotton, S., Shulze, R. & Lomeli, N. (1998) Copper transport. Am. J. Clin. Nutr. 67 (suppl.): 965S-971S.
4. Mercer, J.F.B. (2001) The molecular basis of copper-transport diseases. Trends Mol. Med. 7: 64-69.
5. Milne, D. B., Davis, C. D. & Nielsen, F. H. (2001) Low dietary zinc alters indices of copper function and status in postmenopausal women. Nutrition 17: 701-708.
6. El-Hendy, H. A., Yousef, M. I. & El-Naga, N. I. (2001) Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper and iron in growing rats. Toxicology 167: 163-170.
7. Gupta, R. P., Verma, P. C., Sadana, J. R. & Gupta, V. K. (1989) Effect of experimental zinc deficiency and repletion on sodium, potassium, copper and iron concentrations in guinea-pigs. Br. J. Nutr. 62: 407-414.
8. Linder, M. C. (1991) Nutrition and metabolism of the trace elements. In: Nutritional Biochemistry and Metabolism (Linder, M. C., ed.) pp. 215-276. Elsevier Medical, New York, NY.
9. Reinstein, N. H., Lönnerdal, B., Keen, C. L. & Hurley, L. S. (1984) Zinc-copper interactions in the pregnant rat: fetal outcome and maternal and fetal zinc, copper and iron. J. Nutr. 114: 1266-1279.
10. Beshgetoor, D. & Lönnerdal, B. (1997) Effect of marginal maternal zinc deficiency in rats on mammary gland zinc metabolism. J. Nutr. Biochem. 8: 573-578.
11. Lönnerdal, B. (1998) Copper nutrition during infancy and childhood. Am. J. Clin. Nutr. 67: 1046S-1053S.
12. Zhou, B. & Gitschier, J. (1997) hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc. Natl. Acad. Sci. U.S.A. 94: 7481-7486.
13. Lee, J., Prohaska, J. R., Dagenais, S. L., Glover, T. W. & Thiele, D. J. (2000) Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant. Gene 254: 87-96.
14. Lee, J., Pena, M. M. O., Nose, Y. & Thiele, D. J. (2002) Biochemical characterization of the human copper transporter Ctr1. J. Biol. Chem. 277: 4380-4387.
15. Petris, M. J., Smith, K., Lee, J. & Thiele, D. J. (2002) Copper-stimulated endocytosis and degradation of the human Cu transporter, hctr1. J. Biol. Chem. 278: 9639-9646.
16. Danks, D. M., Stevens, B. J., Campbell, P. E., Cartwright, E. C., Gillespie, J. M. Townley, R. R., Blomfield, J., Turner, B. B., Mayne, V. & Walker-Smith, J. A. (1974) Menkes kinky hair syndrome. An inherited defect in the intestinal absorption of copper with widespread effects. Birth Defects 10: 132-137.
17. Camakaris, J., Petris, M. J., Bailey, L., Shen, P., Lockhart, P., Glover, T. W., Barcroft, C., Patton, J. & Mercer, J. F. (1995) Gene amplification of the Menkes (MNK: ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux. Hum. Mol. Genet. 4: 2117-2123.
18. Grimes, A., Hearn, C. J., Lockhart, P., Newgreen, D. F. & Mercer, J. F. (1997) Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease. Hum. Mol. Genet. 6: 1037-1042.
19. Ackland, M. L., Anikijenko, P., Michalczyk, A. & Mercer, J.F.B. (1999) Expression of Menkes Cu-transporting ATPase, MNK, in the lactating human breast: possible role in copper transport into milk. J. Histochem. Cytochem. 4: 1553-1561.
20. Michalczyk, A. A., Reiger, J., Allen, K. J., Mercer, J.F.B. & Ackland, M. L. (2000) Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation. Biochem. J. 352: 565-571.
21. La-Fontaine, S., Theophilos, M. B., Firth, S. D., Gould, R., Parton, R. G. & Mercer, J.F.B. (2001) Effect of toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copper ATPase. Hum. Mol. Genet. 10: 361-370.
22. Reeves, P. G., Nielsen, F. H., & Fahey, G. C., Jr. (1993) AIN-93 purified diets of laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951.
23. Kelleher, S. L. & Lönnerdal, B. (2001) Long-term marginal intakes of zinc and retinol affect retinol homeostasis without compromising circulating levels during lactation in rats. J. Nutr. 131: 3237-3242.
24. Clegg, M. S., Keen, C. L., Lönnerdal, B. & Hurley, L. S. (1981) Influence of ashing techniques on the concentration of trace elements in animals tissues. I: Wet ashing. Biol. Trace Elem. Res. 3: 107-115.
25. Schosinsky, K. H., Lehman, H. P. & Beeler, M. F. (1974) Analysis of ceruloplasmin activity using o-dianisidine dihydrochloride. Clin. Chem. 20: 1556-1563.
26. Osendarp, S. J., West, C. E., and Black, R. E. (2003) The need for maternal zinc supplementation in developing countries: an unresolved issue. J. Nutr. 133: 817S-827S.
27. Meyer, L. A., Durley, A. P., Prohaska, J. R. & Harris, Z. L. (2001) Copper transport and metabolism are normal in mice aceruloplasminemic mice. J. Biol. Chem. 276: 36857-36861.
28. Donley, S. A., Ilagan, B. J., Rim, H. & Linder, M. C. (2002) Copper transport to mammary gland and milk during lactation in rats. Am. J. Physiol. 283: E667-E675.
29. Brewer, G. J., Hill, G. M., Dick, R. D., Prasad, A. S. & Cossack, Z. T. (1985) Interactions of trace elements: clinical significance. J. Am. Coll. Nutr. 4: 33-38.
30. Eisses, J. F. & Kaplan, J. H. (2002) Molecular characterization of hctr1, the human copper uptake protein. J. Biol. Chem. 277: 29162-71.
31. Klomp, A.E.M., Top, B.B.J., VanDenBerg, E. T., Berger, R. & Klomp, L. W. J. (2002) Biochemical characterization and sub-cellular localization of human copper transporter 1 (hCTR1). Biochem. J. 364: 497-505.
32. Reeves, P. G., Briske-Anderson, M. & Johnson, L. (1998) Physiologic concentrations of zinc affect the kinetics of copper uptake and transport in the human intestinal cell model, Caco-2. J. Nutr. 128: 1794-1801.
33. Ackland, M. L., Cornish, E. J., Paynter, J. A., Grimes, A., Michalczyk, A., & Mercer, J.F.B. (1997) Expression of Menkes disease gene in mammary carcinoma cells. Biochem. J. 328: 237-243.
34. Yamaguchi, Y., Heiny, M. E., Suzuki, M. & Gitlin, J. D. (1996) Biochemical characterization and intracellular localization of the Menkes disease protein. Proc. Natl. Acad. Sci. U.S.A. 93: 14030-14035.
35. Petris, M. J. & Mercer, J.F.B. (1999) The Menkes protein (ATP7A:MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal. Hum. Mol. Genet. 8: 2107-2115.
36. Roelofsen, H., Wolters, H., vanLuyn, M. U., Miura, N., Kuipers, F. & Vonk R. J. (2000) Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion. Gastroenterology 119: 782-793.
37. Yamada, T., Agui, T., Suzuki, Y., Sato, M. & Matsumuto, K. (1993) Inhibition of copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans cinnamon mutant rat. J. Biol. Chem. 268: 8966-8971.
38. Kelleher, S. L. & Lönnerdal, B. (2002) Zinc transporters in the mammary gland respond to marginal zinc and vitamin A intake during lactation in rats. J. Nutr. 132: 3280-3285.
39. DiDonato, M., Zhang, J., Que, L. & Sarkar, B. (2002) Zinc binding to the N-terminal domain of the Wilson disease copper transporting ATPase: Implications for in vivo metal ion mediated regulation of ATPase activity. J. Biol. Chem. 277: 13409-13414.