Protective effect of quercetin, a polyphenolic compound, on mouse corpus cavernosum

Fundamental and Clinical Pharmacology

Volumn 24, Issue 2, 2010, Pages 223-232

  Ertuǧ, Peyman U ^a   Olguner, Anil A ^a   Öǧülener, Nuran ^a   Şingirik, Ergin ^a  

^a CUKUROVA UNIVERSITY   (Turkey)

Author keywords

Antioxidant; Corpus cavernosum; Nitric oxide; Quercetin

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; ACETYLCHOLINE; DIETHYLDITHIOCARBAMIC ACID; HYDROQUINONE; NITRIC OXIDE; PHENYLEPHRINE; PYROGALLOL; QUERCETIN; SODIUM NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTROSTIMULATION; EXPERIMENTAL MOUSE; ISOLATED ORGAN; MALE; MOUSE; MUSCLE CONTRACTION; MUSCLE RELAXATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; MALE; MICE; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; OXIDATIVE STRESS; PENIS; PHENYLEPHRINE; QUERCETIN; SODIUM NITRITE;

EID: 77949878408     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2009.00755.x     Document Type: Article

References (46)

1. Saenz de Tejada I. Nitric oxide as a mediator of relaxation of the corpus cavernosum. N. Engl. J. Med. (1992) 326 1638.
2. Toda N., Ayajiki K., Okamura T. Nitric oxide and penile erectile function. Pharmacol. Thera. (2005) 106 233 266.
3. Bayraktutan U. Free radicals, diabetes and endothelial dysfunction. Diabetes Obes. Metab. (2002) 4 224 238.
4. Jones R.W., Reer R.W., Minhas S., Ralph D., Persad R.A., Jeremy J.Y. Oxygen free radicals and the penis, Expert. Opin. Pharmacother. (2002) 3 889 897.
5. Herrmann K. Of the occurence of flavonol and flavone glycosides in vegetables. Z. Lebensm. Unters. Forsch. (1988) 186 1 5.
6. Hertog M.G.L., Hollman P.C.H., Von de Putte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. J. Agric. Food. Chem. (1993) 41 1242 1246.
7. Formica J.V., Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. (1995) 33 1061 1080.
8. Gryglewski R.J., Korbut R., Robat J., Swies J. On the mechanism of antithrombotic action of flavonoids. Biochem. Pharmacol. (1987) 36 317 322.
9. Ranelletti F.O., Ricci R., Larocca L.M. et al. Growth-inhibitory effect of quercetin and presence of type 2 estrogen-binding sites in human colon cancer cell lines and primary colorectal tumors. Int. J. Cancer (1992) 50 4866 4892.
10. Sgaragli G.P., Valoti M., Garelli B., Fusi F., Palmi M., Mantovani P. Calcium antagonist and antiperoxidant properties of some hindered phenols. Br. J. Pharmacol. (1993) 110 369 377.
11. Morel I., Lescoat G., Cagnel P. et al. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem. Pharmacol. (1993) 45 13 19.
12. Heijnen C.G., Haenen G.R., Vekemans J.A., Bast A. Peroxynitrite scavenging of flavonoids: structure activity relationship. Environ. Toxicol. Pharmacol. (2001) 10 199 206.
13. Huk I., Brovkovych V., Nanobash Vili J. et al. Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: an experimental study. Br. J. Surg. (1996) 85 1080 1085.
14. Chang W.S., Lee Y.J., Lu F.J., Chiang H.C. Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Res. (1993) 13 2165 2170.
15. Sánchez M., Galisteo M., Vera R. et al. Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J. Hypertens. (2006) 24 75 84.
16. López-López G., Moreno L., Cogolludo A. et al. Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle. Mol. Pharmacol. (2004) 65 851 859.
17. Göçmen C., Seçilmiş A., Uçar P. et al. A possible role of S-nitrosothiols at the nitrergic relaxations in the mouse corpus cavernosum. Eur. J. Pharmacol. (1998) 361 85 92.
18. Göçmen C., Seçilmiş A., Kumcu E.K. et al. Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. Eur. J. Pharmacol. (2000) 398 93 98.
19. Göçmen C., Uçar P., Singirik E., Dikmen A., Baysal F. An in vitro study of nonadrenergic-noncholinergic activity on the cavernous tissue of mouse. Urol. Res. (1997) 25 269 275.
20. Ajay M., Achike F.I., Mustafa A.M., Mustafa M.R. Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid. Clin. Exp. Pharmacol. Physiol. (2006) 33 345 350.
21. Martin S., Andriambeloson E., Takeda K., Andriantsitohaina R. Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production. Br. J. Pharmacol. (2002) 135 1579 1587.
22. 3/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J. (2005) 19 455 457.
23. Ignarro L.J., Bryns R.E., Buga G.M., Wasd G.V., Chaudhuri G. Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation. J. Pharmacol. Exp. Ther. (1988) 244 181 189.
24. 2+ superoxide dismutase inhibition on nitrergic relaxations in the rat gastric fundus. Br. J. Pharmacol. (1996) 119 1022 1028.
25. Lilley E., Gibson A. Inhibition of relaxations to nitrergic stimulation of the mouse anococcygeus by duroquinone. Br. J. Pharmacol. (1995) 116 3231 3236.
26. Barbier A.J.M., Lefebvre R.A. Effect of LY 83583 on relaxation induced by non-adrenergic non-cholinergic nerve stimulation and exogenous nitric oxide in the rat gastric fundus. Eur.J. Pharmacol. (1992) 219 331 334.
27. Lefebvre R.A. Influence of superoxide dismutase inhibition on the discrimination between NO and the nitrergic neurotransmitter in the rat gastric fundus. Br. J. Pharmacol. (1996) 118 2171 2177.
28. Gibson A., Brave S.R., McFadzean I., Tucker J.F., Wayman C. The nitrergic neurotransmitter of the anococcygeus NO or not? Arch. Int. Pharmacodyn. Ther. (1995) 329 39 51.
29. Kelner M.J., Bagnell R., Hole B., Alexander N.M. Inactivation of intracellular copper-zinc superoxide dismutase by copper chelating agents without glutathione depletion and methemoglobin formation. Free. Rad. Biol. Med. (1989) 6 355 360.
30. Gibson A., Lilley E. Superoxide anions, free-radical scavengers, and nitrergic neurotransmission. Gen. Pharmac. (1997) 28 489 493.
31. Martin W., McAllister K.H.M., Paisley K. NANC neurotransmission in the bovine retractor penis is blocked by superoxide anion following inhibition of superoxide dismutase with diethyldithiocarbamate. Neuropharmacology (1994) 33 1293 1301.
32. Paisley K., Martin W. Blockade of nitrergic transmission by hydroquinone, hydroxocobalamin and carboxy-PTIO in bovine retractor penis: role of superoxide anions. Br. J. Pharmacol. (1996) 117 1633 1638.
33. Liu X., Miller S.M., Szurszewski J.H. Protection of nitrergic transmission by colocalization of neuronal nitric oxide synthase with copper-zinc superoxide dismutase. J. Auton. Nerv. System. (1997) 62 126 133.
34. Shimocawa H., Matoba T. Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. Pharmacol. Res. (2004) 49 543 549.
35. Mian K.B., Martin W. Differential sensitivity of basal and acetylcholine-stimulated activity of nitric oxide to destruction by superoxide anion in rat aorta. Br. J. Pharmacol. (1995) 115 993 1000.
36. Laight D.W., Kaw A.V., Carrier M.J., Anggard E.E. Interaction between superoxide anion and nitric oxide in the regulation of vascular endothelial function. Br. J. Pharmacol. (1998) 124 238 244.
37. Flavahan N.A., Vanhoutte P.M. Mechanisms underlying the inhibitory interaction between the nitrovasodilator SIN-1 and the endothelium. J. Cardiovasc. Pharmacol. (1989) 14 86 90.
38. Kojda G., Beck J.K., Meyer W., Noack E. Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis manga: dependence and intact endothelium. Br. J. Pharmacol. (1994) 112 533 540.
39. Hallen K., Gustafsson L.E., Wiklund N.P. Nerve-induced release of nitric oxide from the rabbit corpus cavernosum is modulated by cyclic guanosine 3',5'-monophosphate. Neuroscience (2005) 133 169 174.
40. Mülsch A., Lückhoff A., Pohl U., Busse R., Bossenge E. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increase and inhibition of platelet activation. Naunyn Schmeideberg's Arch. Pharmacol. (1989) 340 119 125.
41. De Backer O., Colpaert E.E., Lefebvre R.A. Influence of polyethylene-glycol-superoxide dismutase and combined depletion and repletion of antioxidant on nitrergic relaxation in the pig gastric fundus. Eur. J. Pharmacol. (2004) 486 223 232.
42. Malta E., Macdonald P.S., Dusting G.J. Inhibition of vascular muscle relaxation by LY 83583. Naunyn Schmeideberg's Arch. Pharmacol. (1988) 337 459 464.
43. Guilmard C., Auguet M., Chabrier P. Comparison between endothelial and neuronal nitric oxide pathways in rat aorta and gastric fundus. Nitric Oxide: Biol-Chem. (1998) 2 147 154.
44. Mülsch A., Busse R., Liebau S., Förstermann U. LY 83583 interferes with the release of the endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J. Pharmacol. Exp. Ther. (1988) 247 283 288.
45. Schmalhausen E.V., Zhlobek E.B., Shalova I.N., Firuzi O., Saso L., Muronetz V.I. Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase. Food Chem. Toxicol. (2007) 45 1988 1993.
46. Boots A.W., Kubben N., Haenen G.R.M.M., Bast A. Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation. Biochem. Biophys. Res. Comm. (2003) 308 560 565.