Moisture-activated rheological structuring of nonaqueous poloxamine-poly(acrylic acid) systems designed as novel biomedical implants

Journal of Pharmaceutical Sciences

Volumn 99, Issue 4, 2010, Pages 1838-1854

  Jones, David S ^a   Muldoon, Brendan C O ^a,c   Woolfson, A David ^a   Andrews, Gavin P ^a   McCoy, Colin P ^a   Sanderson, F Dominic ^b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Warner Chilcott (UK) Ltd   (United Kingdom)

Author keywords

Mucoadhesion; Polyacrylic acid; Rheological structuring; Rheology; Tetronic

Indexed keywords

ACRYLIC ACID DERIVATIVE; BIOMATERIAL; CARBOMER; METRONIDAZOLE; PHOSPHATE BUFFERED SALINE; POLOXAMINE POLY(ACRYLIC ACID); TETRONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS HUMOR; ARTICLE; BLOOD RHEOLOGY; DRUG RELEASE; MOISTURE; MOLECULAR INTERACTION; MUCOADHESION; VISCOELASTICITY;

EID: 77949850493     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21956     Document Type: Article

References (47)

1. Attwood D, Collett JH, O'Conor CA. 1990. The effect of gamma irradiation on the surface, rheological and micellar behaviour of the block copolymer, Tetronic 908. Int J Pharm 65:201-205.
2. Schmolka IR. 1991. A comparison of block copolymer surfactant gels. J Am Oil Chem Soc 68:206-209.
3. Spancake CW, Mitra AK, Kildsig DO. 1991. Kinetics of aspirin hydrolysis in aqueous solutions and gels of poloxamines (Tetronic 1508) - Influence of microenvironment. Int J Pharm 75:231-239.
4. Miyazaki S, Oda M, Takada M, Attwood D. 1995. Thermally gelling poloxamine synperonic T908 solution as a vehicle for rectal drug delivery. Biol Pharm Bull 18:1151-1153.
5. Choi H, Jung J, Ryu J, Yoon S, Oh Y, Kim C. 1998. Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository. Int J Pharm 165:33-44.
6. Spancake CW, Kildsig DO, Mitra AK. 1991. Thermorheologic properties of aqueous solutions and gels of Tetronic 1508. Pharm Res 8:345-349.
7. Wang SL, Li DX, Liu X, Zhang JH, Wu CF. 2004. An ocular drug delivery system containing zinc diethyldithiocarbamate and HP beta CD inclusion complex-corneal permeability, ant-cataract effects and mechanism studies. J Pharm Pharmacol 56: 1251-1257.
8. Pongianyakul T, Priprem A, Puttipipatkhacorn S. 2005. Influence of magnesium aluminium silicate on rheological, release and permeation characteristics of diclofenac sodium aqueous gels in vitro. J Pharm Pharmacol 57:429-434.
9. Jones DS, Brown AF, Woolfson AD. 2003. Solute and solvent effects on the thermorheological properties of poly(oxyethylene)-poly(oxypropylene) block copolymers: Implications for pharmaceutical dosage form design. J Appl Polym Sci 87:1016-1026.
10. Quezada A, Larson J, French M, Ponce R, Perrard J, Durland R, Coleman M. 2004. Biodistribution and safety studies of hDel-1 plasmid-baased gene therapy in mouse and rabbit models. J Pharm Pharmacol 56:177-185.
11. Richard P, Bossard F, Desigaux L, Lanctin C, Bello-Roufai M, Pitard B. 2005. Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles. Human Gene Ther 16:1318-1324.
12. Olbrich C, Scholer N, Tabatt K, Kayser O, Muller RH. 2004. Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages - Impact of phagocytosis on viability and cytokine production. J Pharm Pharmacol 56:883-891.
13. Chellat F, Merhi Y, Moreau A, Yahia L. 2005. Therapeutic potential of nanoparticulate systems for macrophage targeting. Biomaterials 26:7260-7275.
14. Kwon JW, Han YK, Lee WJ, Cho CS, Paik SJ, Cho DI, Lee JH, Wee WR. 2005. Biocompatibility of poloxamer hydrogel as an injectable intraocular lens - A pilot study. J Catar Refract Surg 31: 607-613.
15. Yoo MK, Kweon HY, Lee KG, Lee HC, Cho CS. 2004. Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poloxamer macromer. Int J Biol Macromol 34:263-270.
16. Jones DS, Lawlor MS, Woolfson AD. 2003. Rheological and mucoadhesive characterization of polymeric systems composed of poly(methylvinyletherco-maleic anhydride) and poly(vinylpyrrolidone), designed as platforms for topical drug delivery. J Pharm Sci 92:995-1007.
17. Jones DS, Brown AF, Woolfson AD. 2001. Rheological characterization of bioadhesive, antimicrobial, semisolids designed for the treatment of periodontal diseases: Transient and dynamic viscoelastic and continuous shear analysis. J Pharm Sci 90: 1978-1990.
18. Jones DS, Woolfson D, Brown AF. 1998. Viscoelastic properties of bioadhesive, chlorhexidine- containing semi-solids for topical application to the oropharynx. Pharm Res 15:1131-1136.
19. Jones DS, Woolfson DA, Brown AF. 1997. Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels. Pharm Res 14:450-457.
20. Jones DS, Lawlor MS, Woolfson AD. 2002. Examination of the flow rheological and textural properties of polymer gels composed of poly (methylvinylether-co-maleic anhydride) and poly (vinylpyrrolidone): Rheological and mathematical interpretation of textural parameters. J Pharm Sci 91:2090-2101.
21. Andrews GP, Jones DS. 2006. Rheological characterisation of bioadhesive binary polymeric systems designed as platforms for drug delivery implants. Biomacromolecules 7:899-906.
22. Jones DS. 2002. Pharmaceutical statistics. London: The Pharmaceutical Press. p. 608.
23. Hassan EE, Gallo JM. 1990. A simple rheological method for the in vitro assessment of mucinpolymer bioadhesive bond strength. Pharm Res 7:491-495.
24. Caramella C, Bonferoni MC, Rossi S, Ferrari F. 1994. Rheological and tensile tests for the assessment of polymer-mucin interactions. Eur J Pharm Biopharm 40:213-217.
25. Jones DS, Woolfson AD, Brown AF, Coulter WA, McClelland C, Irwin CR. 2000. Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J Cont Rel 67:357-368.
26. Jones DS, Woolfson DA, Brown AF. 1997. Textural viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Int J Pharm 151:223-233.
27. Itoh K, Yahaba M, Takahashi A, Tsuruya R, Miyazaki S, Dairaku M, Togashi M, Mikami R, Attwood D. 2008. In situ gelling xyloglucan/pectin formulations for oral sustained drug delivery. Int J Pharm 356:95-101.
28. Talasaz A, Ghahremankhani A, Moghadam S, Malekshani M, Atyabi F, Dinarvand R. 2008. In situ gel forming systems of poloxamer 407 and hydroxypropylmethylcellulose mixtures for controlled delivery of vancomycin. J Appl Poly Sci 109:2369-2374.
29. Edsman K, Carlfors J, Petersson R. 1998. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. Eur J Pharm Sci 6:105-112.
30. Jones D, Muldoon B, Woolfson A, Andrews G, Sanderson F. 2008. Physicochemical characterisation of bioactive poly(acrylic acid) organogels as potential antimicrobial implants for the buccal cavity. Biomacromolecules 9:624-633.
31. Zignani M, Tabatabay C, Gurny R. 1995. Topical semisolid drug delivery: Kinetics and tolerance of ophthalmic hydrogels. Adv Drug Del Rev 16:51-60.
32. Paulsson M, Hagerstrom H, Edsman K. 1999. Rheological studies of the gelation of deacetylated gellan gum (Gelrite) in physiological conditions. Eur J Pharm Sci 9:99-105.
33. Vitoria M, Bentley LB, Marchetti JM, Ali-Abi NRZ, Collett JH. 1999. Influence of lecithin on some physical chemical properties of poloxamer gels: Rheological, microscopic and in vitro permeatiuon studies. Int J Pharm 193:49-55.
34. Jones DS, Woolfson AD, Brown AF. 1997. Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels. Pharm Res 14:450-457.
35. Ramachandran S, Chen S, Etzler F. 1999. Rheological characterisation of hydroxypropylcellulose gels. Drug Dev Ind Pharm 25:153-161.
36. Tamburic S, Craig DQM. 1996. The effects of ageing on the rheological, dielectric and mucoadhesive properties of poly(acrylic acid)gel systems. Pharm Res 13:279-283.
37. Oechsner M, Keipert S. 1999. Polyacrylic acid/polyvinylpyrrolidone bipolymeric systems. 1. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry eye syndrome. Eur J Pharm Biopharm 47:113-118.
38. Jauregui B, Munoz ME, Santamaria A. 1995. Rheology of hydroxyethylated starch aqueous systems - Analysis of gel formation. Int J Biol Macromol 17:49-54.
39. Ross-Murphy SB. 1995. Rheological characterisation of gels. J Texture Studies 26:391-400.
40. Barnes HA. 1989. Shear thickening ("dilatancy") in suspensions of nonaggregating solid particles dispersed in Newtonian liquids. J Rheol 33:329-366.
41. Miyazaki S, Kawasaki N, Kubo W, Endo K, Attwood D. 2001. Comparison of in situ gelling formulations for the oral delivery of cimetidine. Int J Pharm 220: 161-168.
42. Bell LC, Peppas AN. 1996. Swelling/syneresis phenomena in gel-forming interpolymer complexes. J Biomat Sci-Poly Ed 7:671-683.
43. Nishi S, Kotaka T. 1985. Complex-forming poly (oxyethylene): poly(acrylic acid)interpenetrating polymer networks. Preparation structure and viscoelastic properties. Macromolecules 18:1519-1525.
44. Stratton LP, Aichu D, Manning MCFC. 1997. Drug delivery matrix containing native protein precipitates suspended in a poloxamer gel. J Pharm Sci. 86:1006-1010.
45. Pereswetoff-Morath L, Edman P. 1995. Influence of osmolarity on nasal absorption of insulin from the thermogelling polymer ethyl (hydroxyethyl) cellulose. Int J Pharm 25:205-213.
46. Bou Karam M, Ponchel G, Grossiord J-L, Duchene D. 1993. Preparation and characterisation of aqueous dispersions of oil coated poly(acrylic acid). J Dispersion Sci Tech 14:427-436.
47. Tamburic S, Craig DQM. 1995. An investigation into the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems. J Cont Rel 37:59-68.