Increased adhesive properties of platelets in sickle cell disease: Roles for αiIbβ3-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity: Research paper

British Journal of Haematology

Volumn 149, Issue 2, 2010, Pages 280-288

  Proença Ferreira, Renata ^a   Franco Penteado, Carla F ^a   Traina, Fabiola ^a   Saad, Sara T O ^a   Costa, Fernando F ^a   Conran, Nicola ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Adhesion; Cyclic nucleotides; Platelets; Sickle cell disease; Vaso occlusion

Indexed keywords

ALPHA2 INTEGRIN; ALPHA2BBETA3 INTEGRIN; CD41A ANTIGEN; CILOSTAZOL; COLLAGEN; CYCLIC AMP; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB ALPHA; HEMOGLOBIN F; HYDROXYUREA; INTEGRIN; PADGEM PROTEIN; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IIIA; THROMBIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SICKLE CELL ANEMIA; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION;

ADULT; AGED; ANEMIA, SICKLE CELL; BLOOD PLATELETS; CELLS, CULTURED; COLLAGEN; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; FEMALE; FIBRINOGEN; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PLATELET ADHESIVENESS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; TETRAZOLES; YOUNG ADULT;

EID: 77949849394     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08087.x     Document Type: Article

References (34)

1. Bailey, L., Kuroyanagi, Y., Franco-Penteado, C.F., Conran, N., Costa, F.F., Ausenda, S., Cappellini, M.D. Ikuta, T. (2007) Expression of the gamma-globin gene is sustained by the cAMP-dependent pathway in beta-thalassaemia. British Journal of Haematology, 138, 382 395.
2. Bellavite, P., Andrioli, G., Guzzo, P., Arigliano, P., Chirumbolo, S., Manzato, F. Santonastaso, C. (1994) A colorimetric method for the measurement of platelet adhesion in microtiter plates. Analytical Biochemistry, 216, 444 450.
3. Bender, A.T. Beavo, J.A. (2006) Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacological Reviews, 58, 488 520.
4. Brittain, J.E., Knoll, C.M., Ataga, K.I., Orringer, E.P. Parise, L.V. (2008) Fibronectin bridges monocytes and reticulocytes via integrin alpha4beta1. British Journal of Haematology, 141, 872 881.
5. Canalli, A.A., Franco-Penteado, C.F., Traina, F., Saad, S.T., Costa, F.F. Conran, N. (2007) Role for cAMP-protein kinase A signalling in augmented neutrophil adhesion and chemotaxis in sickle cell disease. European Journal of Haematology, 79, 330 337.
6. Conran, N. Costa, F.F. (2009) Hemoglobin disorders and endothelial cell interactions. Clinical Biochemistry, 42, 1824 1838.
7. Eriksson, A.C. Whiss, P.A. (2009) Characterization of static adhesion of human platelets in plasma to protein surfaces in microplates. Blood Coagulation and Fibrinolysis, 20, 197 206.
8. Feijge, M.A., Ansink, K., Vanschoonbeek, K. Heemskerk, J.W. (2004) Control of platelet activation by cyclic AMP turnover and cyclic nucleotide phosphodiesterase type-3. Biochemical Pharmacology, 67, 1559 1567.
9. van Gils, J.M., Zwaginga, J.J. Hordijk, P.L. (2009) Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. Journal of Leukocyte Biology, 85, 195 204.
10. Hidalgo, A., Chang, J., Jang, J.E., Peired, A.J., Chiang, E.Y. Frenette, P.S. (2009) Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nature Medicine, 15, 384 391.
11. Hines, P.C., Zen, Q., Burney, S.N., Shea, D.A., Ataga, K.I., Orringer, E.P., Telen, M.J. Parise, L.V. (2003) Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. Blood, 101, 3281 3287.
12. Hung, S.H., Liu, A.H., Pixley, R.A., Francis, P., Williams, L.D., Matsko, C.M., Barnes, K.D., Sivendran, S., Colman, R.F. Colman, R.W. (2008) A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3′,5′-cyclic- S-(4-bromo-2,3-dioxobutyl)-monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A. Bioorganic Chemistry, 36, 141 147.
13. Keefer, J.R., Schneidereith, T.A., Mays, A., Purvis, S.H., Dover, G.J. Smith, K.D. (2006) Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells. Experimental Hematology, 34, 1151 1161.
14. King, S.B. (2004) Nitric oxide production from hydroxyurea. Free Radical Biology & Medicine, 37, 737 744.
15. Kuroyanagi, Y., Kaneko, Y., Muta, K., Park, B.S., Moi, P., Ausenda, S., Cappellini, M.D. Ikuta, T. (2006) cAMP differentially regulates gamma-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression. Biochemical and Biophysical Research Communications, 344, 1038 1047.
16. Lee, S.P., Ataga, K.I., Orringer, E.P., Phillips, D.R. Parise, L.V. (2006) Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammation. Arteriosclerosis, Thrombosis and VascularBiology, 26, 1626 1631.
17. Maurice, D.H. Haslam, R.J. (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Molecular Pharmacology, 37, 671 681.
18. Montes, R.A., Eckman, J.R., Hsu, L.L. Wick, T.M. (2002) Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vaso-occlusion. American Journal of Hematology, 70, 216 227.
19. Naseem, K.M. Riba, R. (2008) Unresolved roles of platelet nitric oxide synthase. Journal of Thrombosis and Haemostasis, 6, 10 19.
20. Oberprieler, N.G., Roberts, W., Graham, A.M., Homer-Vanniasinkam, S. Naseem, K.M. (2007a) Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. Biochemical Pharmacology, 73, 1593 1601.
21. Oberprieler, N.G., Roberts, W., Riba, R., Graham, A.M., Homer-Vanniasinkam, S. Naseem, K.M. (2007b) cGMP-independent inhibition of integrin alphaIIbbeta3-mediated platelet adhesion and outside-in signalling by nitric oxide. FEBS Letters, 581, 1529 1534.
22. O'Donnell, M.E., Badger, S.A., Sharif, M.A., Makar, R.R., Young, I.S., Lee, B. Soong, C.V. (2009) The vascular and biochemical effects of cilostazol in diabetic patients with peripheral arterial disease. Vascular and Endovascular Surgery, 43, 132 143.
23. Papadimitriou, C.A., Travlou, A., Kalos, A., Douratsos, D. Lali, P. (1993) Study of platelet function in patients with sickle cell anemia during steady state and vaso-occlusive crisis. Acta Haematologica, 89, 180 183.
24. Rodgers, G.P., Schechter, A.N., Noguchi, C.T., Klein, H.G., Nienhuis, A.W. Bonner, R.F. (1984) Periodic microcirculatory flow in patients with sickle-cell disease. New England Journal of Medicine, 311, 1534 1538.
25. Setty, B.N., Kulkarni, S., Rao, A.K. Stuart, M.J. (2000) Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activation. Blood, 96, 1119 1124.
26. Tabuchi, A. Kuebler, W.M. (2008) Endothelium-platelet interactions in inflammatory lung disease. Vascular Pharmacology, 49, 141 150.
27. Tomer, A., Harker, L.A., Kasey, S. Eckman, J.R. (2001) Thrombogenesis in sickle cell disease. Journal of Laboratory and Clinical Medicine, 137, 398 407.
28. Villagra, J., Shiva, S., Hunter, L.A., Machado, R.F., Gladwin, M.T. Kato, G.J. (2007) Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin. Blood, 110, 2166 2172.
29. Wagner, D.D. Frenette, P.S. (2008) The vessel wall and its interactions. Blood, 111, 5271 5281.
30. Westwick, J., Watson-Williams, E.J., Krishnamurthi, S., Marks, G., Ellis, V., Scully, M.F., White, J.M. Kakkar, V.V. (1983) Platelet activation during steady state sickle cell disease. Journal of Medicine, 14, 17 36.
31. Wood, K.C., Hebbel, R.P. Granger, D.N. (2004) Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice. American Journal of Physiology. Heart and Circulatory Physiology, 286, H1608 H1614.
32. Wun, T., Paglieroni, T., Field, C.L., Welborn, J., Cheung, A., Walker, N.J. Tablin, F. (1999) Platelet-erythrocyte adhesion in sickle cell disease. Journal of Investigative Medicine, 47, 121 127.
33. Wun, T., Cordoba, M., Rangaswami, A., Cheung, A.W. Paglieroni, T. (2002) Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease. Clinical and Laboratory Haematology, 24, 81 88.
34. Zhang, W. Colman, R.W. (2007) Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A. Blood, 110, 1475 1482.