Estrogen modulates iodoacetate-induced gene expression in bovine cartilage explants

Journal of Orthopaedic Research

Volumn 28, Issue 5, 2010, Pages 607-615

  Sniekers, Yvonne H ^a   Van Osch, Gerjo J V M ^a   Jahr, Holger ^a   Weinans, Harrie ^a   Van Leeuwen, Johannes P T M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Cartilage; Estrogen; Explant culture; Gene expression

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; COLLAGENASE 3; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; GELATINASE A; GROWTH FACTOR; IODOACETIC ACID; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; VASCULOTROPIN;

ANIMAL TISSUE; ARTICLE; CARTILAGE; CONTROLLED STUDY; DOWN REGULATION; EXPERIMENTAL MODEL; EXPLANT; FEMALE; GENE CONTROL; GENE EXPRESSION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; UPREGULATION;

AGGRECANS; ANIMALS; CATTLE; COLLAGEN TYPE II; DRUG INTERACTIONS; ENZYME INHIBITORS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IODOACETATES; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; ORGAN CULTURE TECHNIQUES; OSTEOARTHRITIS; TRANSFORMING GROWTH FACTOR BETA3;

EID: 77949848902     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21042     Document Type: Article

References (49)

1. Felson DT, Nevitt MC. 1998. The effects of estrogen on osteoarthritis. Curr Opin Rheumatol 10:269-272.
2. Oliveria SA, Felson DT, Reed JI, et al. 1995. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum 38:1134-1141.
3. Sniekers YH, Weinans H, Bierma-Zeinstra SM, et al. 2008. Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach. Osteoarthritis Cartilage 16:533-541.
4. Hoegh-Andersen P, Tanko LB, Andersen TL, et al. 2004. Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application. Arthritis Res Ther 6:R169-R180.
5. Ham KD, Loeser RF, Lindgren BR, et al. 2002. Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. Arthritis Rheum 46:1956-1964.
6. Sniekers YH, Botter SM, van Osch GJVM, et al. 2007. Abstract: Subchondral bone changes in a murine model for postmenopausal osteoarthritis. Osteoarthritis Cartilage 15:C57-C58.
7. Kalbhen DA, Blum U. 1977. Theoretisches Konzept und experimentell Bestatigung fur ein neues Arthrose-Modell am Versuchstier. Arzneimittelforschung 27:527-531.
8. Kalbhen D. 1985. Degenerative joint disease following chondrocyte injury - chemically induced osteoarthritis. In: Verbruggen G, Veys E, editors. Degenerative joints. Amsterdam: Elsevier Science; p 299-309.
9. Dunham J, Hoedt-Schmidt S, Kalbhen DA. 1992. Structural and metabolic changes in articular cartilage induced by iodoacetate. Int J Exp Pathol 73:455-464.
10. van der Kraan PM, Vitters EL, van de Putte LB, et al. 1989. Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. Am J Pathol 135:1001-1014.
11. Braidman IP, Hainey L, Batra G, et al. 2001. Localization of estrogen receptor beta protein expression in adult human bone. J Bone Miner Res 16:214-220.
12. Arts J, Kuiper GG, Janssen JM, et al. 1997. Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067-5070.
13. Lerner UH. 2006. Bone remodeling in post-menopausal osteoporosis. J Dent Res 85:584-595.
14. Ushiyama T, Ueyama H, Inoue K, et al. 1999. Expression of genes for estrogen receptors alpha and beta in human articular chondrocytes. Osteoarthritis Cartilage 7:560-566.
15. Kinney RC, Schwartz Z, Week K, et al. 2005. Human articular chondrocytes exhibit sexual dimorphism in their responses to 17beta-estradiol. Osteoarthritis Cartilage 13:330-337.
16. Claassen H, Schunke M, Kurz B. 2005. Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage. Cell Tissue Res 319:439-445.
17. Richette P, Dumontier MF, Tahiri K, et al. 2007. Oestrogens inhibit interleukin 1beta-mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-kappa B impairment. Ann Rheum Dis 66:345-350.
18. Richette P, Dumontier MF, Francois M, et al. 2004. Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes. Ann Rheum Dis 63:191-199.
19. Lee YJ, Lee EB, Kwon YE, et al. 2003. Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproteinase-1 in osteoarthritis chondrocytes. Rheumatol Int 23:282-288.
20. Oestergaard S, Sondergaard BC, Hoegh-Andersen P, et al. 2006. Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation. Arthritis Rheum 54:2441-2451.
21. van Osch GJ, van der Kraan PM, van den Berg WB. 1994. Site-specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase. J Orthop Res 12:168-175.
22. van Osch GJ, van der Kraan PM, van den Berg WB. 1993. In vivo quantification of proteoglycan synthesis in articular cartilage of different topographical areas in the murine knee joint. J Orthop Res 11:492-499.
23. Uitterlinden EJ, Jahr H, Koevoet JL, et al. 2007. Glucosamine reduces anabolic as well as catabolic processes in bovine chondrocytes cultured in alginate. Osteoarthritis Cartilage 15:1267-1274.
24. Karsdal MA, Madsen SH, Christiansen C, et al. 2008. Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther 10:R63.
25. Rayan V, Hardingham T. 1994. The recovery of articular cartilage in explant culture from interleukin-1 alpha: effects on proteoglycan synthesis and degradation. Matrix Biol 14:263-271.
26. Johnson EO, Charchandi A, Babis GC, et al. 2008. Apoptosis in osteoarthritis: morphology, mechanisms, and potential means for therapeutic intervention. J Surg Orthop Adv 17:147-152.
27. Zhao H, Qiu GX, Guan J, et al. 2008. [Correlation of apoptosis of articular chondrocytes in osteoarthritis with degree of cartilage destruction and expression of apoptosis-related proteins: surviving, caspase-3, and Bcl-xl]. Zhonghua Yi Xue Za Zhi 88:1339-1341.
28. Ruiz-Romero C, Carreira V, Rego I, et al. 2008. Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis. Proteomics 8:495-507.
29. Bos PK, DeGroot J, Budde M, et al. 2002. Specific enzymatic treatment of bovine and human articular cartilage: implications for integrative cartilage repair. Arthritis Rheum 46:976-985.
30. Pfaffl MW, Tichopad A, Prgomet C, et al. 2004. Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper - Excel-based tool using pair-wise correlations. Biotechnol Lett 26:509-515.
31. Maneix L, Beauchef G, Servent A, et al. 2008. 17Beta-oestradiol up-regulates the expression of a functional UDP-glucose dehydrogenase in articular chondrocytes: comparison with effects of cytokines and growth factors. Rheumatology (Oxford) 47:281-288.
32. Claassen H, Schluter M, Schunke M, et al. 2006. Influence of 17beta-estradiol and insulin on type II collagen and protein synthesis of articular chondrocytes. Bone 39:310-317.
33. Pink JJ, Jordan VC. 1996. Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Res 56:2321-2330.
34. van Osch GJ, van der Kraan PM, van den Berg WB. 1994. Site specific inhibition of cartilage proteoglycan synthesis in the murine knee joint. Differences between 3 metabolic stimuli. J Rheumatol 21:1107-1112.
35. Glansbeek HL, van Beuningen HM, Vitters EL, et al. 1998. Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints. Lab Invest 78:133-142.
36. Hulejova H, Baresova V, Klezl Z, et al. 2007. Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone. Cytokine 38:151-156.
37. Barve RA, Minnerly JC, Weiss DJ, et al. 2007. Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease. Osteoarthritis Cartilage 15:1190-1198.
38. Enomoto H, Inoki I, Komiya K, et al. 2003. Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am J Pathol 162:171-181.
39. Pufe T, Petersen W, Tillmann B, et al. 2001. The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum 44:1082-1088.
40. Pfander D, Kortje D, Zimmermann R, et al. 2001. Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints. Ann Rheum Dis 60:1070-1073.
41. Pufe T, Lemke A, Kurz B, et al. 2004. Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol 164:185-192.
42. Sztrolovics R, White RJ, Roughley PJ, et al. 2002. The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism. Biochem J 362:465-472.
43. Murata M, Yudoh K, Masuko K. 2008. The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis? Osteoarthritis Cartilage 16:279-286.
44. Ma HL, Blanchet TJ, Peluso D, et al. 2007. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 15:695-700.
45. Calvo E, Castaneda S, Largo R, et al. 2007. Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits. Osteoarthritis Cartilage 15:69-77.
46. Parker D, Hwa SY, Sambrook P, et al. 2003. Estrogen replacement therapy mitigates the loss of joint cartilage proteoglycans and bone mineral density induced by ovariectomy and osteoarthritis. APLAR J Rheumatol 6:116-127.
47. Liu SH, al-Shaikh R, Panossian V, et al. 1996. Primary immunolocalization of estrogen and progesterone target cells in the human anterior cruciate ligament. J Orthop Res 14:526-533.
48. Dietrich W, Haitel A, Holzer G, et al. 2006. Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig 13:512-517.
49. Kahlert S, Grohe C, Karas RH, et al. 1997. Effects of estrogen on skeletal myoblast growth. Biochem Biophys Res Commun 232:373-378.