DPPH scavenging assay of novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico studies on some proteins involved in Alzheimer's disease signaling cascade

Letters in Drug Design and Discovery

Volumn 7, Issue 3, 2010, Pages 214-224

  Sarojini, Balladka Kunhanna ^a   Vidyagayatri, Marakkur ^a,b   Darshanraj, Chenna Govindaraju ^a   Bharath, Basavapattana Rudresh ^c   Manjunatha, Hanumanthappa ^c  

^a P A COLLEGE OF ENGINEERING   (India)

^b Syngine Int Ltd   (India)

^c KUVEMPU UNIVERSITY   (India)

Author keywords

secretase; AD; DPPH assay; GSK 3 ; Molecular docking studies; Pyrazole derivative

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; BETA SECRETASE; GLYCOGEN SYNTHASE KINASE 3BETA; PEPTIDE; PYRAZOLE DERIVATIVE; PYRAZOLONE DERIVATIVE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROMETRY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; SUBSTITUTION REACTION;

EID: 77949761516     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018010790596588     Document Type: Article

References (14)

1. Suh, W. H.; Suslick, K. S.; Suh, Y.H. Therapeutic agents for Alzheimer's disease. Curr. Med. Chem. - Cent. Nerv. Syst. Agent, 2005, 5, 259-269.
2. Kedar, N.P.; William, C. C, Prasad, K.C. Risk Factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J. Am. Coll. Nutr., 2002, 21, 506-522.
3. Math, P.; Cuajungco, L.E.; Akihiko Nunomurai, M. A.; Smithi, J. T.; Lim, C.S.; Atwood, X. Huang.; Yasser, W. F.; George, P.; Ashley, I. B. Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc. J. Biol. Chem., 2000, 275, 19439-19442.
4. Rajendran, L.; Schneider, A.; Schlechtingen, G.; Weidlich, S.; Ries, J.; Braxmeier, T.; Schwille, P.; Schulz, J.B.; Schroeder, C.; Simons, M.; Jennings, G.; Knolker, H.J.; Simon, K. Efficient inhibition of the Alzheimer's disease β-secretase by membrane targeting. Science, 2008, 25, 520-523.
5. Jorgensen, W.L. The many roles of computation in drug discovery. Science, 2004, 303, 1813-1818.
6. Tramontano, A. The role of molecular modeling in biomedical research. FEBS Lett., 2006, 580, 2928-2934.
7. Rao B.S.; Akberali P.M.; Holla B.S.; Sarojini B.K. Synthesis and studies on some new fluorine containing hydroxypyrazolines and 1H pyrazoles- as possible antiproliferative agents. J. Pharm. Toxicol., 2008, 3(2), 102-103.
8. Holla, B.S.; .Rao, B.S.; Sarojini, B.K.; Akberali, P.M.; Kumari, N.S. Synthesis and Studies on some new fluorine containing triazolothiadiazines as possible antibacterial, antifungal and anticancer studies. Eur. J. Med. Chem., 2006, 41, 657-663.
9. Narayana, B.; Ashalatha, B.V.; Vijayaraj, K.K.; Fernandes, J.; Sarojini, B.K. Synthesis of some new biologically active 1,3,4-oxadiazolyl nitroindoles and modified Fisher indole synthesis of ethyl nitro indole-2- carboxylates. Bioorg. Med. Chem., 2005, 13, 4638-4644.
10. Pal, S.; Mareddy, J.; Devi, N. S. High speed synthesis of pyrazolones using microwave-assisted neat reaction technology. J. Braz. Chem. Soc., 2008, 19, 1207-1214.
11. Kokura, S.; Yoshida, N.; Sakamoto, N.; Ishikawa, T.; Takagi. T.; Higashihara. H.; Nakabe, N.; Handa, O.; Naito, Y.; Yoshikawa, T. The radical scavenger edaravone. Cancer Lett., 2005, 229, 223-233.
12. Tiwari, A. K. Antioxidants: New-generation therapeutic base for treatment of polygenic disorders. Curr. Sci., 2004, 86, 1092-1100.
13. KEGG Pathway Database. Wiring diagrams of Molecular Interactions, Reactions, and relations. http://www.genome.jp/kegg/ pathway [Accessed: Jan 28, 2009].
14. th ed.; Pearson education Pvt. Ltd: Singapore, 2005, pp. 1102.