C1 inhibitor level on neonatal sepsis and its relations with clinical findings

Journal of Paediatrics and Child Health

Volumn 46, Issue 3, 2010, Pages 121-124

  Tapisiz, Anil ^a   Ergenekon, Ebru ^a   Oktem, Murat ^b   Koc, Esin ^a   Okumus, Nurullah ^b   Zenciroǧlu, Aysegül ^c   Atalay, Yildiz ^a  

^a GAZI UNIVERSITY   (Turkey)

^b Duzen Laboratories   (Turkey)

^c Sami Ulus Hospital   (Turkey)

Author keywords

C1 inhibitor; Newborn; Sepsis

Indexed keywords

COMPLEMENT COMPONENT C1S INHIBITOR;

ANTIBIOTIC THERAPY; ARTICLE; BLOOD CULTURE; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EDEMA; GESTATIONAL AGE; HUMAN; NEWBORN; NEWBORN SEPSIS; PRIORITY JOURNAL; URINE VOLUME; WEIGHT CHANGE;

BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COMPLEMENT C1 INACTIVATOR PROTEINS; EDEMA; HUMANS; INFANT, NEWBORN; SEPSIS;

EID: 77949723354     PISSN: 10344810     EISSN: 14401754     Source Type: Journal    
DOI: 10.1111/j.1440-1754.2009.01649.x     Document Type: Article

References (17)

1. Goldstein B, Giroir B, Randolph A International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr. Crit. Care Med. 2005 6 : 2 8.
2. Morven S, Baker E, Baker JC. Sepsis in the newborn. In : Katz SL, Gershon AA, Hotez PJ, eds. Krugman's Infectious Disease of Children, 10th edn. St Louis : Mosby, 1998 415 428.
3. Hack CE, Nuijens JH, Felt-Bersma RJ et al. Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis. Am. J. Med. 1989 86 : 20 6.
4. Lepow IH, Ratnoff OD, Rosen FS, Pillemer L. Observations on a pro-esterase associated with partially purified first component of human complement (C1). Proc. Soc. Exp. Biol. Med. 1956 92 : 32 7.
5. Sim RB, Arlaud GJ, Colomb MG. Kinetics of reaction of human C1-inhibitor with the human complement system proteases C1r and C1s. Biochim. Biophys. Acta 1980 612 : 433 449.
6. Nuijens JH, Eerenberg-Belmer AJ, Huijbregts, CC et al. Proteolytic inactivation of plasma C1-inhibitor in sepsis. J. Clin. Invest. 1989 84 : 443 450.
7. Davis AE 3rd., Cai S, Liu D. The biological role of the C1 inhibitor in regulation of vascular permeability and modulation of inflammation. Adv. Immunol. 2004 82 : 331 363.
8. Donaldson VH, Evans RR. A biochemical abnormality in herediatry angioneurotic edema: absence of serum inhibitor of c'1-esterase. Am. J. Med. 1963 35 : 37 44.
9. Schapira M, de Agostini A, Schifferli JA, Colman RW. Biochemistry and pathophysiology of human C1 inhibitor: current issues. Complement 1985 2 : 111 126.
10. Caliezi C, Wuillemin WA, Zeerleder S, Redondo M, Eisele B, Hack CE. C1-Esterase inhibitor: an anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema. Pharmacol. Rev. 2000 52 : 91 112.
11. Hack CE, Ogilvie AC, Eisele B, Eerenberg AJ, Wagstaff J, Thijs LG. C1-inhibitor substitution therapy in septic shock and in the vascular leak syndrome induced by high doses of interleukin-2. Intensive Care Med. 1993 19 (Suppl 1 19 28.
12. Hack CE, Voerman HJ, Eisele B et al. C1-esterase inhibitor substitution in sepsis. Lancet 1992 339 : 378.
13. Liu D, Zhang D, Scafidi J, Wu X, Cramer CC, Davis AE. C1 inhibitor prevents gram negative bacterial lipopolysaharide-induced vascular permeability. Blood 2005 105 : 2350 2355.
14. Stieh J, Harding P, Scheewe J, Dutschke P, Kramer HH. Capillary leak sendrome after open heart surgery for congenital heart defects: therapy with C1 inhibitor. Biomed. Prog. 1996 9 : 13 16.
15. Nürnberger W, Göbel U, Stannigel H, Eisele B, Janssen A, Delvos U. C1-inhibitor concentrate for sepsis-related capillary leak sendrome. Lancet 1992 339 : 990.
16. Tassani P, Kunkel R, Richter JA et al. Effect of C1-esterase-inhibitor on capillary leak and inflammatory response syndrome during arterial switch operations in neonates. J. Cardiothorac. Vasc. Anesth. 2001 15 : 469 473.
17. Hazelzet JA, de Groot R, van Mierlo G et al. Complement activation in relation to capillary leakage in children with septic shock and purpura. Infect. Immun. 1998 66 : 5350 5356.