Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes

Journal of Bacteriology

Volumn 192, Issue 7, 2010, Pages 1774-1784

  Schär, Jennifer ^a,c   Stoll, Regina ^a   Schauer, Kristina ^b   Loeffler, Daniela I M ^a,d   Eylert, Eva ^b   Joseph, Biju ^a   Eisenreich, Wolfgang ^b   Fuchs, Thilo M ^b   Goebel, Werner ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; GLUCOSE; GLUTAMIC ACID; GLYCEROL; OXALOACETIC ACID; PYRUVATE CARBOXYLASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CARBON METABOLISM; CARBOXYLATION; CATALYSIS; CELL DIVISION; CONTROLLED STUDY; FEMALE; GENE INSERTION; GENETIC CODE; HUMAN; HUMAN CELL; LISTERIA MONOCYTOGENES; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WILD TYPE;

BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES; MAMMALIA;

EID: 77949710247     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01132-09     Document Type: Article

References (29)

1. Dussurget, O., J. Pizarro-Cerda, and P. Cossart. 2004. Molecular determinants of Listeria monocytogenes virulence. Annu. Rev. Microbiol. 58:587-610.
2. 13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA. Proc. Natl. Acad. Sci. U. S. A. 103:2040-2045.
3. Eylert, E., J. Schär, S. Mertins, R. Stoll, A. Bacher, W. Goebel, and W. Eisenreich. 2008. Carbon metabolism of Listeria monocytogenes growing inside macrophages. Mol. Microbiol. 69:1008-1017.
4. Freitag, N. E. 2006. From hot dogs to host cells: how the bacterial pathogen Listeria monocytogenes regulates virulence gene expression. Future Microbiol. 1:89-101.
5. Fuchs, T. M., J. Klumpp, and K. Przybilla. 2006. Insertion-duplication mutagenesis of Salmonella enterica and related species using a novel thermosensitive vector. Plasmid 55:39-49.
6. Fujita, Y. 2009. Carbon catabolite control of the metabolic network in Bacillus subtilis. Biosci. Biotechnol. Biochem. 73:245-259.
7. Glaser, P., L. Frangeul, C. Buchrieser, C. Rusniok, A. Amend, F. Baquero, P. Berche, H. Bloecker, P. Brandt, T. Chakraborty, A. Charbit, F. Chetouani, E. Couvé, A. de Daruvar, P. Dehoux, E. Domann, G. Domínguez-Bernal, E. Duchaud, L. Durant, O. Dussurget, K. D. Entian, H. Fsihi, F. Garcia-del Portillo, P. Garrido, L. Gautier, W. Goebel, N. Gómez-López, T. Hain, J. Hauf, D. Jackson, L. M. Jones, U. Kaerst, J. Kreft, M. Kuhn, F. Kunst, G. Kurapkat, E. Madueno, A. Maitournam, J. M. Vicente, E. Ng, H. Nedjari, G. Nordsiek, S. Novella, B. de Pablos, J. C. Pérez-Diaz, R. Purcell, B. Remmel, M. Rose, T. Schlueter, N. Simoes, A. Tierrez, J. A. Vázquez-Boland, H. Voss, J. Wehland, and P. Cossart. 2001. Comparative genomics of Listeria species. Science 294:849-852.
8. Hamon, M., H. Bierne, and P. Cossart. 2006. Listeria monocytogenes: a multifaceted model. Nat. Rev. Microbiol. 4:423-434.
9. Janausch, I. G., E. Zientz, Q. H. Tran, A. Kroger, and G. Unden. 2002. C4-dicarboxylate carriers and sensors in bacteria. Biochim. Biophys. Acta 1553:39-56.
10. Joseph, B., and W. Goebel. 2007. Life of Listeria monocytogenes in the host cells' cytosol. Microbes Infect. 9:1188-1195.
11. Joseph, B., S. Mertins, R. Stoll, J. Schar, K. R. Umesha, Q. Luo, S. Muller-Altrock, and W. Goebel. 2008. Glycerol-metabolism and PrfA activity in Listeria monocytogenes. J. Bacteriol. 190:5412-5430.
12. Joseph, B., K. Przybilla, C. Stühler, K. Schauer, J. Slaghuis, T. M. Fuchs, and W. Goebel. 2006. Identification of Listeria monocytogenes genes contributing to intracellular replication by expression profiling and mutant screening. J. Bacteriol. 188:556-568.
13. Lecuit, M. 2005. Understanding how Listeria monocytogenes targets and crosses host barriers. Clin. Microbiol. Infect. 11:430-436.
14. Marr, A. K., B. Joseph, S. Mertins, R. Ecke, S. Müller-Altrock, and W. Goebel. 2006. Overexpression of PrfA leads to growth inhibition of Listeria monocytogenes in glucose-containing culture media by interfering with glucose uptake. J. Bacteriol. 188:3887-3901.
15. Mauder, N., R. Ecke, S. Mertins, D. I. Loeffler, G. Seidel, M. Sprehe, W. Hillen, W. Goebel, and S. Müller-Altrock. 2006. Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes. J. Bacteriol. 188:7941-7956.
16. Mertins, S., B. Joseph, M. Goetz, R. Ecke, G. Seidel, M. Sprehe, W. Hillen, W. Goebel, and S. Müller-Altrock. 2007. Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes. J. Bacteriol. 189:473-490.
17. Premaratne, R. J., W. J. Lin, and E. A. Johnson. 1991. Development of an improved chemically defined minimal medium for Listeria monocytogenes. Appl. Environ. Microbiol. 57:3046-3048.
18. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
19. Sauer, U., and B. J. Eikmanns. 2005. The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteria. FEMS Microbiol. Rev. 29:765-794.
20. Schnupf, P., and D. A. Portnoy. 2007. Listeriolysin O: a phagosome-specific lysin. Microbes Infect. 9:1176-1187.
21. Scortti, M., H. J. Monzo, L. Lacharme-Lora, D. A. Lewis, and J. A. Vazquez-Boland. 2007. The PrfA virulence regulon. Microbes Infect. 9:1196-1207.
22. Seveau, S., T. N. Tham, B. Payrastre, A. D. Hoppe, J. A. Swanson, and P. Cossart. 2007. A FRET analysis to unravel the role of cholesterol in Rac1 and PI 3-kinase activation in the InlB/Met signalling pathway. Cell. Microbiol. 9:790-803.
23. Stoll, R., and W. Goebel. 7 January 2010. Identification of the major PEP-phosphotransferase systems (PTS) for glucose, mannose and cellobiose of Listeria monocytogenes and their significance for extra- and intracellular growth. Microbiology [Epub ahead of print.] doi:10.1099/mic.0.034934-0.
24. Stülke, J., M. Arnaud, G. Rapoport, and I. Martin-Verstraete. 1998. PRD-a protein domain involved in PTS-dependent induction and carbon catabolite repression of catabolic operons in bacteria. Mol. Microbiol. 28:865-874.
25. Tsai, H. N., and D. A. Hodgson. 2003. Development of a synthetic minimal medium for Listeria monocytogenes. Appl. Environ. Microbiol. 69:6943-6945.
26. 2+-citrate transporter CitM. Microbiology 148:3405-3412.
27. Wuenscher, M. D., S. Kohler, W. Goebel, and T. Chakraborty. 1991. Gene disruption by plasmid integration in Listeria monocytogenes: insertional inactivation of the listeriolysin determinant lisA. Mol. Gen. Genet. 228:177-182.
28. Yang, Y. H., S. Dudoit, P. Luu, D. M. Lin, V. Peng, J. Ngai, and T. P. Speed. 2002. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30:e15.
29. 3 carboxylation at the interface of glycolysis and the TCA cycle of Bacillus subtilis. Metab. Eng. 6:277-284.