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Volumn 5, Issue 3, 2010, Pages

Microarrays reveal early transcriptional events during the termination of larval diapause in natural populations of the mosquito, Wyeomyia smithii

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL GENE; DIAPAUSE; DNA TRANSCRIPTION; LARVAL DEVELOPMENT; MICROARRAY ANALYSIS; MOSQUITO; NONHUMAN; PHOTOPERIODIC RESPONSE GENE 1; PHOTOPERIODICITY; WYEOMYIA SMITHII; ANIMAL; BIOLOGICAL MODEL; DNA MICROARRAY; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LARVA; LIFE CYCLE; LIGHT; METABOLISM; PRENATAL DEVELOPMENT; QUANTITATIVE TRAIT LOCUS;

EID: 77949707733     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009574     Document Type: Article
Times cited : (51)

References (58)
  • 4
    • 31144448456 scopus 로고    scopus 로고
    • Eco-physiological phases of insect diapause
    • Koštál V (2006) Eco-physiological phases of insect diapause. J Insect Physiol 52: 113-127.
    • (2006) J Insect Physiol , vol.52 , pp. 113-127
    • Koštál, V.1
  • 5
    • 0036006820 scopus 로고    scopus 로고
    • Regulation of diapause
    • Denlinger DL (2002) Regulation of diapause. Annu Rev Entomol 47: 93-122.
    • (2002) Annu Rev Entomol , vol.47 , pp. 93-122
    • Denlinger, D.L.1
  • 7
    • 0019051561 scopus 로고
    • Optimal switching to diapause in relation to the onset of winter
    • Taylor F (1980) Optimal switching to diapause in relation to the onset of winter. Theor Popul Biol 18: 125-133.
    • (1980) Theor Popul Biol , vol.18 , pp. 125-133
    • Taylor, F.1
  • 8
    • 0017318049 scopus 로고
    • Geography of photoperiodic response in diapausing mosquito
    • Bradshaw WE (1976) Geography of photoperiodic response in diapausing mosquito. Nature 262: 384-386.
    • (1976) Nature , vol.262 , pp. 384-386
    • Bradshaw, W.E.1
  • 10
    • 0035807819 scopus 로고    scopus 로고
    • Genetic shift in photoperiodic response correlated with global warming
    • Bradshaw WE, Holzapfel CM (2001) Genetic shift in photoperiodic response correlated with global warming. Proc Natl Acad Sci USA 98: 14509-14511.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14509-14511
    • Bradshaw, W.E.1    Holzapfel, C.M.2
  • 11
    • 35348991660 scopus 로고    scopus 로고
    • Shifting of the life cycle and life-history traits of the fall webworm in relation to climate change
    • Gomi T, Nagasaka M, Fukuda T, Hagihara H (2007) Shifting of the life cycle and life-history traits of the fall webworm in relation to climate change. Entomol Exp Appl 125: 179-184.
    • (2007) Entomol Exp Appl , vol.125 , pp. 179-184
    • Gomi, T.1    Nagasaka, M.2    Fukuda, T.3    Hagihara, H.4
  • 12
    • 0027837173 scopus 로고
    • The genetic basis of photoperiodism and evolutionary divergence among populations of the pitcher-plant mosquito, Wyeomyia smithii
    • Hard JJ, Bradshaw WE, Holzapfel CM (1993) The genetic basis of photoperiodism and evolutionary divergence among populations of the pitcher-plant mosquito, Wyeomyia smithii. Am Nat 142: 457-473.
    • (1993) Am Nat , vol.142 , pp. 457-473
    • Hard, J.J.1    Bradshaw, W.E.2    Holzapfel, C.M.3
  • 13
    • 0002166443 scopus 로고
    • Variability in diapause attributes of insects and mites: Some evolutionary and practical implications
    • Dingle H, ed, New York, NY: Springer-Verlag. pp
    • Hoy MA (1978) Variability in diapause attributes of insects and mites: some evolutionary and practical implications. In: Dingle H, ed. Evolution of Insect Migration and Diapause. New York, NY: Springer-Verlag. pp 101-126.
    • (1978) Evolution of Insect Migration and Diapause , pp. 101-126
    • Hoy, M.A.1
  • 14
    • 65349145192 scopus 로고    scopus 로고
    • Complications of complexity: Integrating environmental, genetic and hormonal control of insect diapause
    • Emerson KJ, Bradshaw WE, Holzapfel CM (2009) Complications of complexity: Integrating environmental, genetic and hormonal control of insect diapause. Trends Genet 25: 217-225.
    • (2009) Trends Genet , vol.25 , pp. 217-225
    • Emerson, K.J.1    Bradshaw, W.E.2    Holzapfel, C.M.3
  • 15
    • 17144383571 scopus 로고    scopus 로고
    • Amsterdam, NL: Elsevier Science
    • Saunders DS (2002) Insect clocks. Amsterdam, NL: Elsevier Science.
    • (2002) Insect clocks
    • Saunders, D.S.1
  • 16
    • 77951930983 scopus 로고    scopus 로고
    • Bradshaw WE, Holzapfel CM (2010) Light, time and the physiology of biotic response to rapid climate change. Annu Rev Physiol In Press.
    • Bradshaw WE, Holzapfel CM (2010) Light, time and the physiology of biotic response to rapid climate change. Annu Rev Physiol In Press.
  • 17
    • 0001114634 scopus 로고
    • Die endonome Tagesrhythmik als Grundlage der photoperiodischen Reaktion.
    • Bünning E (1936) Die endonome Tagesrhythmik als Grundlage der photoperiodischen Reaktion. Ber Dtsch Bot Ges 54: 590-607.
    • (1936) Ber Dtsch Bot Ges , vol.54 , pp. 590-607
    • Bünning, E.1
  • 18
    • 21244501716 scopus 로고    scopus 로고
    • Geographic and developmental variation in expression of the circadian rhythm gene, timeless, in the pitcher-plant mosquito, Wyeomyia smithii
    • Mathias D, Jacky L, Bradshaw WE, Holzapfel CM (2005) Geographic and developmental variation in expression of the circadian rhythm gene, timeless, in the pitcher-plant mosquito, Wyeomyia smithii. J Insect Physiol 51: 661-667.
    • (2005) J Insect Physiol , vol.51 , pp. 661-667
    • Mathias, D.1    Jacky, L.2    Bradshaw, W.E.3    Holzapfel, C.M.4
  • 19
    • 0025527123 scopus 로고
    • The circadian basis of ovarian diapause regulation in Drosophila melanogaster: Is the period gene causally involved in photoperiodic time measurement?
    • Sauners DS (1990) The circadian basis of ovarian diapause regulation in Drosophila melanogaster: Is the period gene causally involved in photoperiodic time measurement? J Biol Rhythms 5: 315-331.
    • (1990) J Biol Rhythms , vol.5 , pp. 315-331
    • Sauners, D.S.1
  • 20
    • 0024670273 scopus 로고
    • Induction of diapause in Drosophila melanogaster: Photoperiodic regulation and the impact of arrhythmic clock mutations on time measurement
    • Saunders DS, Henrich VC, Gilbert LI (1989) Induction of diapause in Drosophila melanogaster: Photoperiodic regulation and the impact of arrhythmic clock mutations on time measurement. Proc Natl Acad Sci USA 86: 3748-3752.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3748-3752
    • Saunders, D.S.1    Henrich, V.C.2    Gilbert, L.I.3
  • 21
    • 40849137833 scopus 로고    scopus 로고
    • Photoperiodic induction of diapause requires regulated transcription of timeless in the larval brain of Chymomyza costata
    • Stehlík J, Závodská R, Shimada K, Šauman I, Koštál V (2008) Photoperiodic induction of diapause requires regulated transcription of timeless in the larval brain of Chymomyza costata. J Biol Rhythms 23: 129-139.
    • (2008) J Biol Rhythms , vol.23 , pp. 129-139
    • Stehlík, J.1    Závodská, R.2    Shimada, K.3    Šauman, I.4    Koštál, V.5
  • 22
    • 0036694417 scopus 로고    scopus 로고
    • Short-day and long-day expression patterns of genes involved in the flesh fly clock mechanism: Period, timeless, cycle and cryptochrome
    • Goto SG, Denlinger DL (2002) Short-day and long-day expression patterns of genes involved in the flesh fly clock mechanism: period, timeless, cycle and cryptochrome. J Insect Physiol 48: 803-816.
    • (2002) J Insect Physiol , vol.48 , pp. 803-816
    • Goto, S.G.1    Denlinger, D.L.2
  • 23
    • 34347393197 scopus 로고    scopus 로고
    • Natural selection favors a newly derived timeless allele in Drosophila melanogaster
    • Tauber E, Zordan M, Sandrelli F, Pegoraro M, Osterwalder N, et al. (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 316: 1895-1898.
    • (2007) Science , vol.316 , pp. 1895-1898
    • Tauber, E.1    Zordan, M.2    Sandrelli, F.3    Pegoraro, M.4    Osterwalder, N.5
  • 25
  • 27
    • 0017568452 scopus 로고
    • Evolution of dormancy and its photoperiodic control in pitcher-plant mosquitoes
    • Bradshaw WE, Lounibos LP (1977) Evolution of dormancy and its photoperiodic control in pitcher-plant mosquitoes. Evolution 31: 546-567.
    • (1977) Evolution , vol.31 , pp. 546-567
    • Bradshaw, W.E.1    Lounibos, L.P.2
  • 28
    • 46649087128 scopus 로고    scopus 로고
    • Extrinsic light:dark cycles, rather than endogenous circadian cycles, affect the photoperiodic timer in the pitcher-plant mosquito, Wyeomyia smithii
    • Emerson KJ, Letaw AD, Bradshaw WE, Holzapfel CM (2008) Extrinsic light:dark cycles, rather than endogenous circadian cycles, affect the photoperiodic timer in the pitcher-plant mosquito, Wyeomyia smithii. J Comp Phys A 194: 611-615.
    • (2008) J Comp Phys A , vol.194 , pp. 611-615
    • Emerson, K.J.1    Letaw, A.D.2    Bradshaw, W.E.3    Holzapfel, C.M.4
  • 29
    • 34347374206 scopus 로고    scopus 로고
    • Quantitative trait loci associated with photoperiodic response and stage of diapause in the pitcher-plant mosquito, Wyeomyia smithii
    • Mathias D, Jacky L, Bradshaw WE, Holzapfel CM (2007) Quantitative trait loci associated with photoperiodic response and stage of diapause in the pitcher-plant mosquito, Wyeomyia smithii. Genetics 176: 391-402.
    • (2007) Genetics , vol.176 , pp. 391-402
    • Mathias, D.1    Jacky, L.2    Bradshaw, W.E.3    Holzapfel, C.M.4
  • 30
    • 0001677717 scopus 로고
    • Controlling the false discovery rate - a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate - a practical and powerful approach to multiple testing. J Roy Stat Soc B Meth 57: 289-300.
    • (1995) J Roy Stat Soc B Meth , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 31
    • 70349193687 scopus 로고    scopus 로고
    • Annotation and analysis of low-complexity protein families of Anopheles gambiae that are associated with cuticle
    • Cornman RS, Willis JH (2009) Annotation and analysis of low-complexity protein families of Anopheles gambiae that are associated with cuticle. Insect Mol Biol 18: 607-622.
    • (2009) Insect Mol Biol , vol.18 , pp. 607-622
    • Cornman, R.S.1    Willis, J.H.2
  • 32
    • 0034710157 scopus 로고    scopus 로고
    • The evolution of cell adhesion
    • Hynes RO, Zhao Q (2000) The evolution of cell adhesion. J Cell Biol 150: F89-F95.
    • (2000) J Cell Biol , vol.150
    • Hynes, R.O.1    Zhao, Q.2
  • 33
    • 0037329502 scopus 로고    scopus 로고
    • Roles of myosin phosphatase during Drosophila development
    • Tan C, Stronach B, Perrimon N (2003) Roles of myosin phosphatase during Drosophila development. Development 130: 671-681.
    • (2003) Development , vol.130 , pp. 671-681
    • Tan, C.1    Stronach, B.2    Perrimon, N.3
  • 34
    • 34548215055 scopus 로고    scopus 로고
    • Seasonal photoperiodism regulates the expression of cuticular and signalling protein genes in the pea aphid
    • Le Trionnaire G, Jaubert S, Sabater-Munoz B, Benedetto A, Bonhomme J, et al. (2007) Seasonal photoperiodism regulates the expression of cuticular and signalling protein genes in the pea aphid. Insect Biochem Mol Biol 37: 1094-1102.
    • (2007) Insect Biochem Mol Biol , vol.37 , pp. 1094-1102
    • Le Trionnaire, G.1    Jaubert, S.2    Sabater-Munoz, B.3    Benedetto, A.4    Bonhomme, J.5
  • 36
    • 0344889214 scopus 로고    scopus 로고
    • Downregulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs
    • Török I, Herrmann-Horle D, Kiss I, Tick G, Speer G, et al. (1999) Downregulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs. Mol Cell Biol 19: 2308-2321.
    • (1999) Mol Cell Biol , vol.19 , pp. 2308-2321
    • Török, I.1    Herrmann-Horle, D.2    Kiss, I.3    Tick, G.4    Speer, G.5
  • 37
    • 3042842875 scopus 로고    scopus 로고
    • Cloning, characterization, and developmental expression of the ribosomal protein S21 gene of the Mediterranean fruit fly Ceratitis capitata
    • Verras M, Theodoraki MA, Mintzas AC (2004) Cloning, characterization, and developmental expression of the ribosomal protein S21 gene of the Mediterranean fruit fly Ceratitis capitata. Arch Insect Biochem Physiol 56: 133-142.
    • (2004) Arch Insect Biochem Physiol , vol.56 , pp. 133-142
    • Verras, M.1    Theodoraki, M.A.2    Mintzas, A.C.3
  • 38
    • 33847413680 scopus 로고    scopus 로고
    • Diapause-specific gene expression in the northern house mosquito, Culex pipiens L., identified by suppressive subtractive hybridization
    • Robich RM, Rinehart JP, Kitchen LJ, Denlinger DL (2007) Diapause-specific gene expression in the northern house mosquito, Culex pipiens L., identified by suppressive subtractive hybridization. J Insect Physiol 53: 235-245.
    • (2007) J Insect Physiol , vol.53 , pp. 235-245
    • Robich, R.M.1    Rinehart, J.P.2    Kitchen, L.J.3    Denlinger, D.L.4
  • 39
    • 0042607298 scopus 로고
    • Overwintering ecology of the aquatic fauna associated with the pitcher plant Sarracenia purpurea L
    • Paterson CG (1971) Overwintering ecology of the aquatic fauna associated with the pitcher plant Sarracenia purpurea L. Can J Zool 49: 1455-1459.
    • (1971) Can J Zool , vol.49 , pp. 1455-1459
    • Paterson, C.G.1
  • 41
    • 34247222063 scopus 로고    scopus 로고
    • Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: Metabolomic and computational systems analysis
    • Feala JD, Coquin L, McCulloch AD, Paternostro G (2007) Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis. Mol Syst Biol 3: 7.
    • (2007) Mol Syst Biol , vol.3 , pp. 7
    • Feala, J.D.1    Coquin, L.2    McCulloch, A.D.3    Paternostro, G.4
  • 42
    • 0032545489 scopus 로고    scopus 로고
    • Sorbitol dehydrogenase of Drosophila: Gene, protein, and expression data show a two gene system
    • Luque T, Hjelmqvist L, Marfany G, Danielsson O, El-Ahmad M, et al. (1998) Sorbitol dehydrogenase of Drosophila: gene, protein, and expression data show a two gene system. J Biol Chem 273: 34293-34301.
    • (1998) J Biol Chem , vol.273 , pp. 34293-34301
    • Luque, T.1    Hjelmqvist, L.2    Marfany, G.3    Danielsson, O.4    El-Ahmad, M.5
  • 43
    • 0027295343 scopus 로고
    • Developmental profile of the gene expression of a Bombyx homolog of mammalian sorbitol dehydrogenase during embryogenesis in non-diapause eggs
    • Niimi T, Yamashita O, Yaginuma T (1993) Developmental profile of the gene expression of a Bombyx homolog of mammalian sorbitol dehydrogenase during embryogenesis in non-diapause eggs. Comp Biochem Physiol B Comp Biochem 106: 437-442.
    • (1993) Comp Biochem Physiol B Comp Biochem , vol.106 , pp. 437-442
    • Niimi, T.1    Yamashita, O.2    Yaginuma, T.3
  • 44
    • 0027162878 scopus 로고
    • A cold inducible Bombyix gene encoding a protein similar to mammalian sorbitol dehydrogenase - yolk nuclei dependent gene expression in diapause eggs
    • Niimi T, Yamashita O, Yaginuma T (1993) A cold inducible Bombyix gene encoding a protein similar to mammalian sorbitol dehydrogenase - yolk nuclei dependent gene expression in diapause eggs. Eur J Biochem 213: 1125-1131.
    • (1993) Eur J Biochem , vol.213 , pp. 1125-1131
    • Niimi, T.1    Yamashita, O.2    Yaginuma, T.3
  • 45
    • 38149008068 scopus 로고    scopus 로고
    • Dynamism in physiology and gene diapause in a heteropteran transcription during reproductive diapause in a heteropteran bug, Pyrrhocoris apterus
    • Koštál V, Tollarova M, Dolezel D (2008) Dynamism in physiology and gene diapause in a heteropteran transcription during reproductive diapause in a heteropteran bug, Pyrrhocoris apterus. J Insect Physiol 54: 77-88.
    • (2008) J Insect Physiol , vol.54 , pp. 77-88
    • Koštál, V.1    Tollarova, M.2    Dolezel, D.3
  • 47
    • 13744253159 scopus 로고    scopus 로고
    • Epistasis underlying a fitness trait within a natural population of the pitcher-plant mosquito, Wyeomyia smithii
    • Bradshaw WE, Haggerty BP, Holzapfel CM (2005) Epistasis underlying a fitness trait within a natural population of the pitcher-plant mosquito, Wyeomyia smithii. Genetics 169: 485-488.
    • (2005) Genetics , vol.169 , pp. 485-488
    • Bradshaw, W.E.1    Haggerty, B.P.2    Holzapfel, C.M.3
  • 48
    • 0030781727 scopus 로고    scopus 로고
    • Evolutionary divergence of the genetic architecture underlying photoperiodism in the pitcher-plant mosquito, Wyeomyia smithii
    • Lair KP, Bradshaw WE, Holzapfel CM (1997) Evolutionary divergence of the genetic architecture underlying photoperiodism in the pitcher-plant mosquito, Wyeomyia smithii. Genetics 147: 1873-1883.
    • (1997) Genetics , vol.147 , pp. 1873-1883
    • Lair, K.P.1    Bradshaw, W.E.2    Holzapfel, C.M.3
  • 49
    • 33644592425 scopus 로고    scopus 로고
    • Evolutionary divergence of circadian and photoperiodic phenotypes in the pitcher-plant mosquito, Wyeomyia smithii
    • Mathias D, Reed LK, Bradshaw WE, Holzapfel CM (2006) Evolutionary divergence of circadian and photoperiodic phenotypes in the pitcher-plant mosquito, Wyeomyia smithii. J Biol Rhythms 21: 132-139.
    • (2006) J Biol Rhythms , vol.21 , pp. 132-139
    • Mathias, D.1    Reed, L.K.2    Bradshaw, W.E.3    Holzapfel, C.M.4
  • 50
    • 52049084358 scopus 로고    scopus 로고
    • Characterization of the Drosophila melanogaster retinin gene encoding a cornea-specific protein
    • Kim E, Choi Y, Lee S, Seo Y, Yoon J, et al. (2008) Characterization of the Drosophila melanogaster retinin gene encoding a cornea-specific protein. Insect Mol Biol 17: 537-543.
    • (2008) Insect Mol Biol , vol.17 , pp. 537-543
    • Kim, E.1    Choi, Y.2    Lee, S.3    Seo, Y.4    Yoon, J.5
  • 51
    • 64149086155 scopus 로고    scopus 로고
    • Evolution of photoperiodic time measurement is independent of the circadian clock in the pitcher-plant mosquito, Wyeomyia smithii
    • Emerson KJ, Dake SJ, Bradshaw WE, Holzapfel CM (2009) Evolution of photoperiodic time measurement is independent of the circadian clock in the pitcher-plant mosquito, Wyeomyia smithii. J Comp Phys A 195: 385-391.
    • (2009) J Comp Phys A , vol.195 , pp. 385-391
    • Emerson, K.J.1    Dake, S.J.2    Bradshaw, W.E.3    Holzapfel, C.M.4
  • 52
    • 38149016849 scopus 로고    scopus 로고
    • Genomic approaches for studying biological clocks
    • Tauber E, Kyriacou CP (2008) Genomic approaches for studying biological clocks. Funct Ecol 22: 19-29.
    • (2008) Funct Ecol , vol.22 , pp. 19-29
    • Tauber, E.1    Kyriacou, C.P.2
  • 53
    • 37349061118 scopus 로고    scopus 로고
    • Genetic response to rapid climate change: It's seasonal timing that matters
    • Bradshaw WE, Holzapfel CM (2008) Genetic response to rapid climate change: it's seasonal timing that matters. Mol Ecol 17: 157-166.
    • (2008) Mol Ecol , vol.17 , pp. 157-166
    • Bradshaw, W.E.1    Holzapfel, C.M.2
  • 54
    • 35748932852 scopus 로고    scopus 로고
    • R Development Core Team , Vienna, Austria: R Foundation for Statistical Computing
    • R Development Core Team (2007) R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
    • (2007) R: A language and environment for statistical computing
  • 55
    • 33644872577 scopus 로고    scopus 로고
    • Limma: Linear models for microarray data
    • Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, eds, New York: Springer. pp
    • Smyth GK (2005) Limma: linear models for microarray data. In: Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, eds. Bioinformatics and computational biology solutions using R and Bioconductor. New York: Springer. pp 397-420.
    • (2005) Bioinformatics and computational biology solutions using R and Bioconductor , pp. 397-420
    • Smyth, G.K.1
  • 56
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical Bayes methods for assessing differential expression in microarray experiments
    • Smyth GK (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat App Gen Mol Biol 3: 3.
    • (2004) Stat App Gen Mol Biol , vol.3 , pp. 3
    • Smyth, G.K.1
  • 57
    • 0004249246 scopus 로고
    • New York, NY: W.H. Freeman and Company
    • Sokal RR, Rohlf FJ (1995) Biometry. New York, NY: W.H. Freeman and Company.
    • (1995) Biometry
    • Sokal, R.R.1    Rohlf, F.J.2
  • 58
    • 0038443885 scopus 로고    scopus 로고
    • Circadian rhythmicity and photoperiodism in the pitcher-plant mosquito: Adaptive response to the photic environment or correlated response to the seasonal environment?
    • Bradshaw WE, Quebodeaux MC, Holzapfel CM (2003) Circadian rhythmicity and photoperiodism in the pitcher-plant mosquito: adaptive response to the photic environment or correlated response to the seasonal environment? Am Nat 161: 735-748.
    • (2003) Am Nat , vol.161 , pp. 735-748
    • Bradshaw, W.E.1    Quebodeaux, M.C.2    Holzapfel, C.M.3


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