Mucosa-associated lymphoid tissue lymphoma: Molecular pathogenesis and clinicopathological significance

Pathology International

Volumn 57, Issue 8, 2007, Pages 474-484

  Inagaki, Hiroshi ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

API2 MALT1 fusion; Autoimmune disease; Chronic inflammation; Cytogenetic alterations; Helicobacter pylori; Lung; Mucosa associated lymphoid tissue (MALT) lymphoma; NF B; Stomach; t(11; 18)(q21; q21)

Indexed keywords

ALKYLATING AGENT; ANTIBIOTIC AGENT; APOPTOSIS INHIBITOR; B LYMPHOCYTE RECEPTOR; CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; FORKHEAD TRANSCRIPTION FACTOR; I KAPPA B KINASE; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN BCL 10; RITUXIMAB; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; T LYMPHOCYTE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANTIBIOTIC THERAPY; APOPTOSIS; AUTOIMMUNE DISEASE; BACTERIAL COLONIZATION; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 18; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; CYTOGENETICS; DISEASE ASSOCIATION; FLUORESCENCE IN SITU HYBRIDIZATION; GASTRITIS; GENE; GENE STRUCTURE; HASHIMOTO DISEASE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA ASSOCIATED TRANSLOCATION 1 GENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SALIVARY GLAND; SJOEGREN SYNDROME; STATISTICAL SIGNIFICANCE; STOMACH LYMPHOMA; STOMACH MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; THYROID GLAND; TRISOMY; TUMOR REGRESSION;

CHROMOSOME ABERRATIONS; HUMANS; LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TISSUE; ONCOGENE PROTEINS, FUSION;

EID: 34447097562     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2007.02128.x     Document Type: Review

References (131)

1. Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer 1983 52 : 1410 16.
2. Isaacson PG, Muller-Hermelink HK, Piris MA et al. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In : Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours. Pathology and Genetics: Tumours of Haemopoietic and Lymphoid Tissues. Lyon, France : IARC Press, 2001 157 60.
3. de Wolf-Peeters C, Pittaluga S, Dierlamm J et al. Marginal zone B-cell lymphomas including mucosa-associated lymphoid tissue type lymphoma (MALT), monocytoid B-cell lymphoma and splenic marginal zone cell lymphoma and their relation to the reactive marginal zone. Leuk Lymphoma 1997 26 : 467 78.
4. Mollejo M, Menarguez J, Lloret E et al. Splenic marginal zone lymphoma: A distinctive type of low-grade B-cell lymphoma - a clinicopathological study of 13 cases. Am J Surg Pathol 1995 19 : 1146 57.
5. Campo E, Miquel R, Krenacs L et al. Primary nodal marginal zone lymphomas of splenic and MALT type. Am J Surg Pathol 1999 23 : 59 68.
6. Nathwani BN, Anderson JR, Armitage JO et al. Marginal zone B-cell lymphoma: A clinical comparison of nodal and mucosa-associated lymphoid tissue types: Non-Hodgkin's Lymphoma Classification Project. J Clin Oncol 1999 17 : 2486 92.
7. Kojima M, Inagaki H, Motoori T et al. Clinical implications of nodal marginal zone B-cell lymphoma among Japanese: Study of 65 cases. Cancer Sci 2007 98 : 44 9.
8. International Lymphoma Study Group. The Non-Hodgkin's Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group Classification of Non-Hodgkins Lymphoma. Blood 1997 89 : 3909 18.
9. Lymphoma Study Group of Japanese Pathologists. The World Health Organization classification of malignant lymphomas in Japan: Incidence of recently recognized entities. Pathol Int 2000 50 : 696 702.
10. Isaacson PG, Spencer J. The biology of low grade MALT lymphoma. J Clin Pathol 1995 48 : 395 7.
11. Ferreri AJ, Guidoboni M, Ponzoni M et al. Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. J Natl Cancer Inst 2004 96 : 586 94.
12. Ferreri AJ, Ponzoni M, Guidoboni M et al. Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: A multicenter prospective trial. J Natl Cancer Inst 2006 98 : 1375 82.
13. Cerroni L, Zochling N, Putz B et al. Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. J Cutan Pathol 1997 24 : 457 61.
14. Parsonnet J, Isaacson PG. Bacterial infection and MALT lymphoma. N Engl J Med 2004 350 : 213 15.
15. Negri E, Little D, Boiocchi M et al. B-cell non-Hodgkin's lymphoma and hepatitis C virus infection: A systematic review. Int J Cancer 2004 111 : 1 8.
16. Tursi A, Brandimarte G, Torello M. Disappearance of gastric mucosa-associated lymphoid tissue in hepatitis C virus-positive patients after anti-hepatitis C virus therapy. J Clin Gastroenterol 2004 38 : 360 63.
17. Zucca E, Bertoni F. Chlamydia or not Chlamydia, that is the question: Which is the microorganism associated with MALT lymphomas of the ocular adnexa? J Natl Cancer Inst 2006 98 : 1348 9.
18. Ye H, Liu H, Raderer M et al. High incidence of t(11;18)(q21;q21) in helicobacter pylori-negative gastric MALT lymphoma. Blood 2003 101 : 2547 50.
19. Inagaki H, Nakamura T, Li C et al. Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter pylori eradication and detection of API2-MALT1 fusion. Am J Surg Pathol 2004 28 : 1560 67.
20. Isaacson PG. Mucosa-associated lymphoid tissue lymphoma. Semin Hematol 1999 36 : 139 47.
21. Chan JK, Ng CS, Isaacson PG. Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach. Am J Pathol 1990 136 : 1153 64.
22. Peng HM, Du M, Diss TC et al. Genetic evidence for a clonal link between low and high-grade components in gastric MALT B-cell lymphoma. Histopathology 1997 30 : 425 9.
23. De Wolf-Peeters C, Achten R. The histogenesis of large-cell gastric lymphomas. Histopathology 1999 34 : 71 5.
24. Iwano M, Watanabe N, Matsushima Y et al. Rapid development of diffuse large B-cell lymphoma after successful eradication of Helicobacter pylori for gastric MALT lymphoma. Am J Gastroenterol 2006 101 : 2878 83.
25. Hoeve MA, Gisbertz IA, Schouten HC et al. Gastric low-grade MALT lymphoma, high-grade MALT lymphoma and diffuse large B cell lymphoma show different frequencies of trisomy. Leukemia 1999 13 : 799 807.
26. Streubel B, Simonitsch-Klupp I, Mullauer L et al. Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites. Leukemia 2004 18 : 1722 6.
27. Remstein ED, Dogan A, Einerson RR et al. The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America. Am J Surg Pathol 2006 30 : 1546 53.
28. Borovecki A, Korac P, Ventura RA, Perisa MM, Banham AH, Dominis M. MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas. Pathol Int 2007 57 : 47 51.
29. Taji S, Nomura K, Matsumoto Y et al. Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy. World J Gastroenterol 2005 11 : 89 93.
30. Ott G, Katzenberger T, Greiner A et al. The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkins lymphomas of the mucosa-associated lymphoid tissue (MALT)-type. Cancer Res 1997 57 : 3944 8.
31. Auer IA, Gascoyne RD, Connors JM et al. t(11;18)(q21;q21) is the most common translocation in MALT lymphomas. Ann Oncol 1997 8 : 979 85.
32. Dierlamm J, Baens M, Wlodarska I et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999 93 : 3601 9.
33. Akagi T, Motegi M, Tamura A et al. A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene 1999 18 : 5785 94.
34. Morgan JA, Yin Y, Borowsky AD et al. Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res 1999 59 : 6205 13.
35. Ye H, Liu H, Attygalle A et al. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: Significant association with CagA strains of H pylori in gastric MALT lymphoma. Blood 2003 102 : 1012 18.
36. Okabe M, Inagaki H, Ohshima K et al. API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Pathol 2003 162 : 1113 22.
37. Baens M, Maes B, Steyls A, Geboes K, Marynen P, De Wolf-Peeters C. The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation. Am J Pathol 2000 156 : 1433 9.
38. Sakugawa ST, Yoshino T, Nakamura S et al. API2-MALT1 fusion gene in colorectal lymphoma. Mod Pathol 2003 16 : 1232 41.
39. Li C, Inagaki H, Kuo TT, Hu S, Okabe M, Eimoto T. Primary cutaneous marginal zone B-cell lymphoma: A molecular and clinicopathologic study of 24 Asian cases. Am J Surg Pathol 2003 27 : 1061 9.
40. Sato Y, Nakamura N, Nakamura S et al. Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas. Mod Pathol 2006 19 : 1578 84.
41. Nakamura S, Ichimura K, Sato Y et al. Follicular lymphoma frequently originates in the salivary gland. Pathol Int 2006 56 : 576 83.
42. Inagaki H, Chan JK, Ng JW et al. Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features. Am J Pathol 2002 160 : 1435 43.
43. Chan ACL, Chan JKC, Inagaki H, Nakamura S, Moeller P. Thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). In : Travis WD, Brambilla E, Mueller-Hermelink HK, Harris CC, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon, France : IARC Press, 2004 225 6.
44. Takada S, Yoshino T, Taniwaki M et al. Involvement of the chromosomal translocation t(11;18) in some mucosa-associated lymphoid tissue lymphomas and diffuse large B-cell lymphomas of the ocular adnexa: Evidence from multiplex reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization on using formalin-fixed, paraffin-embedded specimens. Mod Pathol 2003 16 : 445 52.
45. Adachi A, Tamaru JI, Kaneko K et al. No evidence of a correlation between BCL10 expression and API2-MALT1 gene rearrangement in ocular adnexal MALT lymphoma. Pathol Int 2004 54 : 16 25.
46. Schiby G, Polak-Charcon S, Mardoukh C et al. Orbital marginal zone lymphomas: An immunohistochemical, polymerase chain reaction, and fluorescence in situ hybridization study. Hum Pathol 2007 38 : 435 42.
47. Rosenwald A, Ott G, Stilgenbauer S et al. Exclusive detection of the t(11;18)(q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas. Am J Pathol 1999 155 : 1817 21.
48. Remstein ED, James CD, Kurtin PJ. Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas. Am J Pathol 2000 156 : 1183 8.
49. Dierlamm J, Baens M, Stefanova-Ouzounova M et al. Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes. Blood 2000 96 : 2215 18.
50. Inagaki H, Okabe M, Seto M, Nakamura S, Ueda R, Eimoto T. API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: Multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens. Am J Pathol 2001 158 : 699 706.
51. Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995 83 : 1243 52.
52. Hofmann K, Bucher P, Tschopp J. The CARD domain: A new apoptotic signalling motif. Trends Biochem Sci 1997 22 : 155 6.
53. Roy N, Deveraux QL, Takahashi R et al. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 1997 16 : 6914 25.
54. Uren AGO, Rourke K, Aravind L et al. Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell 2000 6 : 961 7.
55. Lucas PC, Yonezumi M, Inohara N et al. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κB signaling pathway. J Biol Chem 2001 276 : 19 12 19.
56. Motegi M, Yonezumi M, Suzuki H et al. API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products. Am J Pathol 2000 156 : 807 12.
57. Liu H, Hamoudi RA, Ye H et al. t(11;18)(q21;q21) of mucosa-associated lymphoid tissue lymphoma results from illegitimate non-homologous end joining following double strand breaks. Br J Haematol 2004 125 : 318 29.
58. Baens M, Steyls A, Dierlamm J et al. Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. Genes Chromosomes Cancer 2000 29 : 281 91.
59. Izumiyama K, Nakagawa M, Yonezumi M et al. Stability and subcellular localization of API2-MALT1 chimeric protein involved in t(11;18)(q21;q21) MALT lymphoma. Oncogene 2003 22 : 8085 92.
60. Stoffel A, Chaurushiya M, Singh B, Levine AJ. Activation of NF-kappaB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis. Proc Natl Acad Sci USA 2004 101 : 9079 89.
61. Hosokawa Y, Suzuki H, Suzuki Y, Takahashi R, Seto M. Antiapoptotic function of apoptosis inhibitor 2-MALT1 fusion protein. Cancer Res 2004 64 : 3452 7.
62. Zhou H, Wertz I, O'Rourke K et al. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 2004 427 : 167 71.
63. Hosokawa Y. Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma. Apoptosis 2005 10 : 25 34.
64. Zhou H, Du MQ, Dixit VM. Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity. Cancer Cell 2005 7 : 425 31.
65. Baens M, Fevery S, Sagaert X et al. Selective expansion of marginal zone B cells in Emicro-API2-MALT1 mice is linked to enhanced IkappaB kinase gamma polyubiquitination. Cancer Res 2006 66 : 5270 77.
66. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000 102 : 33 42.
67. Verhagen AM, Ekert PG, Pakusch M et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000 102 : 43 53.
68. Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi RA. Serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 2001 8 : 613 21.
69. Nomura K, Yoshino T, Nakamura S et al. Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization. Cancer Genet Cytogenet 2003 140 : 49 54.
70. Liu H, Ye H, Dogan A et al. t(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10. Blood 2001 98 : 1182 7.
71. Ye H, Gong L, Liu H et al. MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression. J Pathol 2005 205 : 293 301.
72. Inagaki H, Nonaka M, Nagaya S, Tateyama H, Sasaki M, Eimoto T. Monoclonality in gastric lymphoma detected in formalin-fixed, paraffin-embedded endoscopic biopsy specimens using immunohistochemistry, in situ hybridization, and polymerase chain reaction. Diagn Mol Pathol 1995 4 : 32 8.
73. Thieblemont C, Berger F, Dumontet C et al. Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed. Blood 2000 95 : 802 6.
74. Harris NL, Jaffe ES, Diebold J et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 1999 17 : 3835 49.
75. Wundisch T, Thiede C, Morgner A et al. Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication. J Clin Oncol 2005 23 : 8018 24.
76. Nakamura S, Matsumoto T, Suekane H et al. Long-term clinical outcome of Helicobacter pylori eradication for gastric mucosa-associated lymphoid tissue lymphoma with a reference to second-line treatment. Cancer 2005 104 : 532 40.
77. Wotherspoon AC, Doglioni C, Diss TC et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993 342 : 575 7.
78. Hussell T, Isaacson PG, Crabtree JE, Spencer J. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 1993 342 : 571 4.
79. Hussell T, Isaacson PG, Crabtree JE, Spencer J. Helicobacter pylori-specific tumour-infiltrating T cells provide contact dependent help for the growth of malignant B cells in low-grade gastric lymphoma of mucosa-associated lymphoid tissue. J Pathol 1996 178 : 122 7.
80. D'Elios MM, Amedei A, Manghetti M et al. Impaired T-cell regulation of B-cell growth in Helicobacter pylori-related gastric low-grade MALT lymphoma. Gastroenterology 1999 117 : 1105 12.
81. Morgner A, Lehn N, Andersen LP et al. Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: Complete remission after curing the infection. Gastroenterology 2000 118 : 821 8.
82. Aviles A, Nambo MJ, Neri N, Talavera A, Cleto S. Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: Results of a controlled clinical trial. Med Oncol 2005 22 : 57 62.
83. Nakamura T, Nakamura S, Yonezumi M et al. Helicobacter pylori and the t(11;18)(q21;q21) translocation in gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Jpn J Cancer Res 2000 91 : 301 9.
84. Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A et al. Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet 2001 357 : 39 40.
85. Liu H, Ye H, Ruskone-Fourmestraux A et al. t(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. Gastroenterology 2002 122 : 1286 94.
86. Sugiyama T, Asaka M, Nakamura T et al. API2-MALT1 chimeric transcript is a predictive marker for the responsiveness of H. pylori eradication treatment in low-grade gastric MALT lymphoma. Gastroenterology 2001 120 : 1884 5.
87. Alpen B, Neubauer A, Dierlamm J et al. Translocation t(11;18) absent in early gastric marginal zone B-cell lymphoma of MALT type responding to eradication of Helicobacter pylori infection. Blood 2000 95 : 4014 15.
88. Sackmann M, Morgner A, Rudolph B et al. Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group. Gastroenterology 1997 113 : 1087 90.
89. Nakamura S, Aoyagi K, Furuse M et al. B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis. Am J Pathol 1998 152 : 1271 9.
90. Nakamura S, Matsumoto T, Suekane H et al. Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori. Gut 2001 48 : 454 60.
91. Ruskone-Fourmestraux A, Lavergne A, Aegerter PH et al. Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment. Gut 2001 48 : 297 303.
92. de Jong D, Vyth-Dreese F, Dellemijn T et al. Histological and immunological parameters to predict treatment outcome of Helicobacter pylori eradication in low-grade gastric MALT lymphoma. J Pathol 2001 193 : 318 24.
93. Sakuma H, Nakamura T, Uemura N et al. Immunoglobulin VH gene analysis in gastric MALT lymphomas. Mod Pathol 2007 20 : 460 66.
94. Levy M, Copie-Bergman C, Gameiro C et al. Prognostic value of translocation t(11;18) in tumoral response of low-grade gastric lymphoma of mucosa-associated lymphoid tissue type to oral chemotherapy. J Clin Oncol 2005 23 : 5061 6.
95. Streubel B, Ye H, Du MQ, Isaacson PG, Chott A, Raderer M. Translocation t(11;18)(q21;q21) is not predictive of response to chemotherapy with 2CdA in patients with gastric MALT lymphoma. Oncology 2004 66 : 476 80.
96. Starostik P, Patzner J, Greiner A et al. Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways. Blood 2002 99 : 3 9.
97. Barth TF, Bentz M, Leithauser F et al. Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract. Genes Chromosomes Cancer 2001 31 : 316 25.
98. Zhou Y, Ye H, Martin-Subero JI et al. Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21). Br J Haematol 2006 133 : 35 42.
99. Remstein ED, Kurtin PJ, James CD, Wang XY, Meyer RG, Dewald GW. Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways. Am J Pathol 2002 161 : 63 71.
100. Fukuhara N, Tagawa H, Nakamura T et al. Genomic imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21)-negative gastric MALT lymphomas. Blood 2006 108 : 2424 (Abstract).
101. Nicholson AG, Wotherspoon AC, Diss TC et al. Pulmonary B-cell non-Hodgkin's lymphomas. The value of immunohistochemistry and gene analysis in diagnosis. Histopathology 1995 26 : 395 403.
102. Kurtin PJ, Myers JL, Adlakha H et al. Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. Am J Surg Pathol 2001 25 : 997 1008.
103. Thieblemont C, Bastion Y, Berger F et al. Mucosa-associated lymphoid tissue gastrointestinal and nongastrointestinal lymphoma behavior: Analysis of 108 patients. J Clin Oncol 1997 15 : 1624 30.
104. Cordier JF, Chailleux E, Lauque D et al. Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients. Chest 1993 103 : 201 8.
105. Lee DK, Im JG, Lee KS et al. B-cell lymphoma of bronchus-associated lymphoid tissue (BALT): CT features in 10 patients. J Comput Assist Tomogr 2000 24 : 30 34.
106. Wislez M, Cadranel J, Antoine M et al. Lymphoma of pulmonary mucosa-associated lymphoid tissue: CT scan findings and pathological correlations. Eur Respir J 1999 14 : 423 9.
107. Inagaki H, Li C, Okabe M et al. Detection of API2-MALT1 fusion transcripts in cytologic specimens of patients with pulmonary mucosa-associated lymphoid tissue lymphoma. Int J Hematol 2005 82 : 59 62.
108. Addis BJ, Hyjek E, Isaacson PG. Primary pulmonary lymphoma: A re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology 1988 13 : 1 17.
109. Cadranel J, Wislez M, Antoine M. Primary pulmonary lymphoma. Eur Respir J 2002 20 : 750 62.
110. Royer B, Cazals-Hatem D, Sibilia J et al. Lymphomas in patients with Sjogren's syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses. Blood 1997 90 : 766 75.
111. Takino H, Okabe M, Li C et al. p16/INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis. Mod Pathol 2005 18 : 1187 92.
112. Yoshida M, Okabe M, Eimoto T et al. Immunoglobulin VH genes in thymic MALT lymphoma are biased toward a restricted repertoire and are frequently unmutated. J Pathol 2006 208 : 415 22.
113. Willis TG, Jadayel DM, Du MQ et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 1999 96 : 35 45.
114. Zhang Q, Siebert R, Yan M et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet 1999 22 : 63 8.
115. Du MQ, Peng H, Liu H et al. BCL10 gene mutation in lymphoma. Blood 2000 95 : 3885 90.
116. Seto M. Genetic and epigenetic factors involved in B-cell lymphomagenesis. Cancer Sci 2004 95 : 704 10.
117. Ruland J, Duncan GS, Elia A et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 2001 104 : 33 42.
118. Xue L, Morris SW, Orihuela C et al. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol 2003 4 : 857 65.
119. Thome M. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol 2004 4 : 348 59.
120. Isaacson PG, Du MQ. MALT lymphoma: From morphology to molecules. Nat Rev Cancer 2004 4 : 644 53.
121. Tian MT, Gonzalez G, Scheer B, DeFranco AL. Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood 2005 106 : 2105 12.
122. Ye H, Dogan A, Karran L et al. BCL10 expression in normal and neoplastic lymphoid tissue: Nuclear localization in MALT lymphoma. Am J Pathol 2000 157 : 1147 54.
123. Ye H, Gong L, Liu H et al. Strong BCL10 nuclear expression identifies gastric MALT lymphomas that do not respond to H pylori eradication. Gut 2006 55 : 137 8.
124. Streubel B, Lamprecht A, Dierlamm J et al. t(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood 2003 101 : 2335 9.
125. Sanchez-Izquierdo D, Buchonnet G, Siebert R et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Blood 2003 101 : 4539 46.
126. Streubel B, Vinatzer U, Lamprecht A et al. t(3;14)(p14.1; q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia 2005 19 : 652 8.
127. Wlodarska I, Veyt E, De Paepe P et al. FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations. Leukemia 2005 19 : 1299 305.
128. Coffer PJ, Burgering BM. Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 2004 4 : 889 99.
129. Barrans SL, Fenton JA, Banham A et al. Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma (DLBCL) patients with poor outcome. Blood 2004 104 : 2933 5.
130. Banham AH, Connors JM, Brown PJ et al. Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Clin Cancer Res 2005 11 : 1065 72.
131. Sagaert X, de Paepe P, Libbrecht L et al. Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma. J Clin Oncol 2006 24 : 2490 97.