Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: A meta-analysis

International Journal of Neuropsychopharmacology

Volumn 13, Issue 1, 2010, Pages 5-14

  Cruz, Nuria ^a,b   Sanchez Moreno, Jose ^c   Torres, Ferran ^d   Goikolea, Jose Manuel ^a   Valent, Marc ^a   Vieta, Eduard ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b MCLEAN HOSPITAL   (United States)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Antipsychotic drugs; Bipolar disorder; Depression; Placebo controlled trials

Indexed keywords

AMISULPRIDE; ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; ASENAPINE; ATYPICAL ANTIPSYCHOTIC AGENT; AZELASTINE; CLOZAPINE; FLUOXETINE; NEUROLEPTIC AGENT; OLANZAPINE; PALIPERIDONE; PLACEBO; QUETIAPINE; RISPERIDONE; ZIPRASIDONE;

ARTICLE; BIPOLAR DEPRESSION; BIPOLAR I DISORDER; BIPOLAR II DISORDER; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; HUMAN; MEDLINE; META ANALYSIS; MONOTHERAPY; MONTGOMERY ASBERG DEPRESSION RATING SCALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REMISSION; SYSTEMATIC REVIEW; TREATMENT RESPONSE;

ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BIPOLAR DISORDER; DIBENZOTHIAZEPINES; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FLUOXETINE; HUMANS; PIPERAZINES; PLACEBOS; QUINOLONES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 77949659513     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145709990344     Document Type: Article

References (42)

1. APA (2002). Practice guidelines for the treatment of patients with bipolar disorder (revision). American Journal of Psychiatry 159, 1-50.
2. Bowden CL, Grunze H, Mullen J, Brecher M, et al. (2005). A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder. Journal of Clinical Psychiatry 66, 111-121.
3. Brugue E, Vieta E (2007). Atypical antipsychotics in bipolar depression: Neurobiological basis and clinical implications. Progress in Neuropsychopharmacology and Biological Psychiatry 31, 275-282.
4. Calabrese JR, Keck Jr. PE, Macfadden W, Minkwitz M, et al. (2005). A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar i or ii depression. American Journal of Psychiatry 162, 1351-1360.
5. Calabrese JR, Shelton MD, Bowden CL, Rapport DJ, et al. (2001). Bipolar rapid cycling: focus on depression as its hallmark. Journal of Clinical Psychiatry 62 (Suppl. 14), 34-41.
6. Colom F, Vieta E, Daban C, Pacchiarotti I, Sanchez-Moreno J (2006). Clinical and therapeutic implications of predominant polarity in bipolar disorder. Journal of Affective Disorders 93, 13-17.
7. Daban C, Colom F, Sanchez-Moreno J, Garcia-Amador M, Vieta E (2006). Clinical correlates of first-episode polarity in bipolar disorder. Comprehensive Psychiatry 47, 433-437.
8. Fountoulakis KN, Vieta E, Siamouli M, Valenti M, et al. (2007). Treatment of bipolar disorder: a complex treatment for a multi-facet disorder. Annals of General Psychiatry 6, 27.
9. Garcia-Amador M, Pacchiaroti I, Valenti M, Sanchez RF, et al. (2006). Role of aripiprazole in treating mood disorders. Expert Review of Neurotherapeutics 6, 1777-1783.
10. Grunze H, Kasper S, Goodwin G, Bowden C, et al. (2002). World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Bipolar Disorders. Part I: Treatment of bipolar depression. World Journal of Biological Psychiatry 3, 115-124.
11. Grunze H, Kasper S, Goodwin G, Bowden C, et al. (2003). The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part II: Treatment of Mania. World Journal of Biological Psychiatry 4, 5-13.
12. Hirschfeld RM, Keck Jr. PE, Kramer M, Karcher K, et al. (2004). Rapid antimanic effect of risperidone monotherapy: a 3-week multicenter, double-blind, placebo-controlled trial. American of Journal Psychiatry 161, 1057-1065.
13. Keck Jr. PE, Marcus R, Tourkodimitris S, Ali M, et al. (2003a). A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania. American of Journal Psychiatry 160, 1651-1658.
14. Keck Jr. PE, Versiani M, Potkin S, West SA, et al. (2003b). Ziprasidone in the treatment of acute bipolar mania: a three-week, placebo-controlled, double-blind, randomized trial. American of Journal Psychiatry 160, 741-748.
15. Khanna S, Vieta E, Lyons B, Grossman F, et al. (2005). Risperidone in the treatment of acute mania: Double-blind, placebo-controlled study. British of Journal Psychiatry 187, 229-234.
16. McIntyre RS, Brecher M, Paulsson B, Huizar K, Mullen J (2005). Quetiapine or haloperidol as monotherapy for bipolar mania-a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial. European Neuropsychopharmacology 15, 573-585.
17. Mitchell PB, Goodwin GM, Johnson GF, Hirschfeld RM (2008). Diagnostic guidelines for bipolar depression: a probabilistic approach. Bipolar Disorders 10, 144-152.
18. Mitchell PB, Malhi GS (2004). Bipolar depression: phenomenological overview and clinical characteristics. Bipolar Disorders 6, 530-539.
19. Perlis RH, Welge JA, Vornik LA, Hirschfeld RM, Keck Jr. PE (2006). Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trials. Journal of Clinical Psychiatry 67, 509-516.
20. Potkin SG, Keck Jr. P.E., Segal S, Ice K, English P (2005). Ziprasidone in acute bipolar mania: a 21-day randomized, double-blind, placebo-controlled replication trial. Journal of Clinical Psychopharmacology 25, 301-310.
21. Sachs G, Chengappa KN, Suppes T, Mullen JA, et al. (2004). Quetiapine with lithium or divalproex for the treatment of bipolar mania: a randomized, double-blind, placebo-controlled study. Bipolar Disorders 6, 213-223.
22. Sachs G, Sanchez R, Marcus R, Stock E, et al. (2006). Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study. Journal of Psychopharmacology 20, 536-546.
23. Sachs GS, Grossman F, Ghaemi SN, Okamoto A, Bowden CL (2002). Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety. American of Journal Psychiatry 159, 1146-1154.
24. Scherk H, Pajonk FG, Leucht S (2007). Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials. Archives of General Psychiatry 64, 442-455.
25. Smulevich AB, Khanna S, Eerdekens M, Karcher K, et al. (2005). Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol. European Neuropsychopharmacology 15, 75-84.
26. Suppes T, Hirschfeld RM, Vieta E, Raines S, Paulsson B (2008). Quetiapine for the treatment of bipolar II depression: analysis of data from two randomized, double-blind, placebo-controlled studies. World Journal of Biological Psychiatry 9, 198-211.
27. Thase ME, Jonas A, Khan A, Bowden CL, et al. (2008). Aripiprazole monotherapy in nonpsychotic bipolar I depression: results of 2 randomized, placebo-controlled studies. Journal of Clinical Psychopharmacology 28, 13-20.
28. Thase ME, Macfadden W, Weisler RH, Chang W, et al. (2006). Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study). Journal of Clinical Psychopharmacology 26, 600-609.
29. Tohen M, Bowden CL, Smulevich AB, Bergstrom R, et al. (2008). Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes. British Journal of Psychiatry 192, 135-143.
30. Tohen M, Chengappa KN, Suppes T, Zarate Jr. CA, et al. (2002). Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy. Archives of General Psychiatry 59, 62-69.
31. Tohen M, Jacobs TG, Grundy SL, McElroy SL, et al. (2000). Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group. Archives of General Psychiatry 57, 841-849.
32. Tohen M, Sanger TM, McElroy SL, Tollefson GD, et al. (1999). Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group. American of Journal Psychiatry 156, 702-709.
33. Tohen M, Vieta E, Calabrese J, Ketter TA, et al. (2003). Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression. Archives of General Psychiatry 60, 1079-1088.
34. Vieta E, Ramey T, Keller D, English PA, et al. (in press). Ziprasidone in the treatment of acute mania: a 12-week placebo-controlled, haloperidol-referenced study. Journal of Psychopharmacology.
35. Vieta E, Suppes T, Eggens I, Persson I, et al. (2008a). Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). Journal of Affective Disorders 109, 251-263.
36. Vieta E, T'joen C, McQuade RD, Carson Jr. WH, et al. (2008b). Efficacy of adjunctive aripiprazole to either valproate or lithium in bipolar mania patients partially nonresponsive to valproate/lithium monotherapy: a placebo-controlled study. American Journal of Psychiatry 165, 1316-1325.
37. Weisler R, Dunn J, English P (2003). Adjunctive ziprasidone for acute bipolar mania: randomized, placebo-controlled trial. 4th International Forum on Mood and Anxiety Disorders, Monte Carlo, Monaco.
38. Yatham LN, Goldstein JM, Vieta E, Bowden CL, et al. (2005a). Atypical antipsychotics in bipolar depression: potential mechanisms of action. Journal of Clinical Psychiatry 66 (Suppl. 5), 40-48.
39. Yatham LN, Grossman F, Augustyns I, Vieta E, Ravindran A (2003). Mood stabilisers plus risperidone or placebo in the treatment of acute mania. International, double-blind, randomised controlled trial. British of Journal Psychiatry 182, 141-147.
40. Yatham LN, Kennedy SH, O'Donovan C, Parikh S, et al. (2005b). Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies. Bipolar Disorders 7 (Suppl. 3), 5-69.
41. Yatham LN, Kennedy SH, O'Donovan C, Parikh SV, et al. (2006). Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007. Bipolar Disorders 8, 721-739.
42. Yatham LN, Vieta E, Young AH, Moller HJ, Paulsson B, Vagero M (2007). A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania. International Clinical Psychopharmacology 22, 212-220.