Risperidone in the treatment of acute mania: Double-blind, placebo-controlled study

British Journal of Psychiatry

Volumn 187, Issue SEPT., 2005, Pages 229-234

  Khanna, Sumant ^a   Vieta, Eduard ^b   Lyons, Benjamin ^c   Grossman, Fred ^c   Eerdekens, Mariëlle ^d   Kramer, Michelle ^c  

^a Psychiatric Clinic   (India)

^b UNIVERSITY OF BARCELONA   (Spain)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CHLORPROMAZINE; HALOPERIDOL; LORAZEPAM; PLACEBO; PROLACTIN; RISPERIDONE;

ADULT; ARTICLE; BIPOLAR I DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DYSKINESIA; DYSTONIA; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HUMAN; HYPERKINESIA; INDIA; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MANIA; MONOTHERAPY; MULTICENTER STUDY; OCULOGYRIC CRISIS; PARKINSONISM; PROLACTIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SUICIDE; WEIGHT GAIN; YOUNG MANIA RATING SCALE;

ACUTE DISEASE; ADULT; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; RISPERIDONE; TREATMENT OUTCOME;

EID: 24944507721     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.187.3.229     Document Type: Article

References (21)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.
2. Chouinard, G., Ross-Chouinard, A., Annable, L., et al (1980) Extrapyramidal Symptom Rating Scale (abstract). Canadian Journal of Neurological Sciences, 7, 233.
3. Endicott, J., Spitzer, R. L., Fleiss, J. C., et al (1976) The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33, 766-771
4. Ghaemi, S. N., Sachs, G. S., Baldassano, C. F., et al (1997) Acute treatment of bipolar disorder with adjunctive risperidone in outpatients. Canadian Journal of Psychiatry, 42, 196-199.
5. Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology. Revised DHEW Pub. (ADM). Rockville, MD: National Institute of Mental Health.
6. Kay, S. R., Fiszbein, A. & Opler, L. A. (1987) The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13, 261-275.
7. Marder, S. R., Davis, J. M. & Chouinard, G. (1997) The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trials. Journal of Clinical Psychiatry, 58, 538-546.
8. Miller, D. S., Yatham, L. N. & Lam, R. W. (2001) Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood stabilizers in the treatment of acute mania. Journal of Clinical Psychiatry, 62, 975-980.
9. Montgomery, S. A. & Åsberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382-389.
10. Sachs, G. S., Grossman, F., Ghaemi, N. S., et al (2002) Risperidone plus mood stabilizer versus placebo plus mood stabilizer for acute mania of bipolar disorder: a double-blind comparison of efficacy and safety. American Journal of Psychiatry, 159, 1146-1154.
11. Sachs, G. S., Chengappa, K. N., Suppes, T., et al (2004) Quetiapine with lithium or divalproex for the treatment of bipolar mania: a randomized, double-blind, placebo-controlled study. Bipolar Disorders, 6, 213-223.
12. Segal, J., Berk, M. & Brook, S. (1998) Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial. Clinical Neuropharmacology, 21, 176-180.
13. Suppes, T., Webb, A., Paul, B., et al (1999) Clinical outcome in a randomized 1-year trial of clozapine versus treatment as usual for patients with treatment-refractory illness and a history of mania. American Journal of Psychiatry, 156, 1164-1169.
14. Tohen, M., Sanger, T. M., McElroy, S. L., et al (1999) Olanzapine versus placebo in the treatment of acute mania. American Journal of Psychiatry, 156, 702-709.
15. Tohen, M., Jacobs, T. G., Grundy, S. L., et al (2000) Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. Archives of General Psychiatry, 57, 841-849.
16. Tohen, M., Chengappa, K. N. R., Suppes, T., et al (2002) Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium therapy. Archives of General Psychiatry, 59, 62-69.
17. Vieta, E., Goikolea, J. M., Corbella, B., et al (2001) Risperidone safety and efficacy in the treatment of bipolar and schizoaffective disorders: results from a 6-month, multicenter, open study. Journal of Clinical Psychiatry, 62, 818-825.
18. Vieta, E., Brugué, E., Goikolea, J. M., et al (2004) Acute and continuation risperidone monotherapy in mania. Human Psychopharmacology: Clinical and Experimental, 19, 41-45.
19. World Medical Association (1989) World Medical Association Declaration of Helsinki: Recommendations Guiding Medical Doctors in Biomedical Research Involving Human Subjects. http://www.fda.gov/oc/health/helsinki89.html.
20. Yatham, L. N., Grossman, F., Augustyns, I., et al (2003) Mood stabilisers plus risperidone or placebo in the treatment of acute mania: international, double-blind, randomised controlled trial. British Journal of Psychiatry, 182, 141-147.
21. Young, R. C., Biggs, J. T., Ziegler, V. E., et of (1978) A rating scale for mania: reliability, validity and sensitivity. British Journal of Psychiatry, 133, 429-435.