Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1880-1897

  Marugan, Juan J ^a   Zheng, Wei ^a   Motabar, Omid ^a   Southall, Noel ^a   Goldin, Ehud ^a   Sidransky, Ellen ^a   Aungst, Ronald A ^b   Liu, Ke ^a   Sadhukhan, Subir Kumar ^c   Austin, Christopher P ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

^c SP Biotech Park   (India)

Author keywords

Acid alpha glucosidase; Activation of GAA; Lysosomal storage disorder; Pompe disease

Indexed keywords

1 (3,4 DIMETHOXYPHENETHYL) 2 THIOXO 2,3 DIHYDROPTERIDIN 4(1H) ONE; 1 (3,4 DIMETHOXYPHENETHYL) 5,7 DIMETHYL 2 THIOXO 2,3 DIHYDROPYRIDO [2,3 D]PYRIMIDIN 4(1H) ONE; 1 (3,4 DIMETHOXYPHENETHYL) 6 PROPYL 2 THIOXO 2,3,5,6,7,8 HEXAHYDROPYRIMIDO[4,5-D]PYRIMIDIN 4(1H) ONE; 1 (3,4 DIMETHOXYPHENETHYL) 6 PROPYL 5,6,7,8 TETRAHYDROPYRIMIDO [4,5 D]PYRIMIDINE 2,4(1H,3 ) DIONE; 1 (3,4 DIMETHOXYPHENETHYL)UREA; 2 THIOXO 2,3 DIHYDROPYRIMIDIN 4(1H) ONE DERIVATIVE; 2 THIOXO 2,3,5,6,7,8 HEXAHYDROPYRIMIDO[4,5 D]PYRIMIDIN 4(1H) ONE; 3 (3,4 DIMETHOXYPHENETHYL) 2 THIOXO 2,3 DIHYDRO 1H PURIN 6(9H) ONE; 5 CHLORO 8 (PHENYLETHYNYL)PYRIDO[4,3 D]PYRIMIDINE; 5 CHLORO 8 [(3,4 DIMETHOXYPHENYL)ETHYNYL]PYRIDO[4,3 D]PYRIMIDINE; 5 CHLORO 8 IODOPYRIDO[4,3 D]PYRIMIDINE; 5,6 DIAMINO 1 (3,4 DIMETHOXYPHENETHYL) 2 THIOXO 2,3 DIHYDROPYRIMIDIN 4(1H) ONE; 6 AMINO 1 (3,4 DIMETHOXYPHENETHYL) 5 NITROSO 2 THIOXO 2, 3 DIHYDROPYRIMIDIN 4(1H) ONE; 6 AMINO 1 (3,4 DIMETHOXYPHENETHYL)PYRIMIDINE 2,4(1H,3H) DIONE; 8 (3,4 DIMETHOXYPHENETHYL)PYRIDO[4,3 D]PYRIMIDIN 5(6H) ONE; 8 (PHENYLETHYL)PYRIDO[4,3 D]PYRIMIDIN 5(6H) ONE; 8 (PHENYLETHYNYL)PYRIDO[4,3 D]PYRIMIDIN 5(6H) ONE; 8 [(3,4 DIMETHOXYPHENYL)ETHYNYL]PYRIDO[4,3 D]PYRIMIDIN 5(6H) ONE; 8 IODOPYRIDO[4,3 D]PYRIMIDIN 5 (6H) ONE; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; CHAPERONE; ENZYME ACTIVATOR; MUTANT PROTEIN; PYRIDO[4,3 D]PYRIMIDIN 5(6H) ONE; UNCLASSIFIED DRUG;

ARTICLE; AUTOFLUORESCENCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG SCREENING; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME ISOLATION; HUMAN; HUMAN TISSUE; HYDROGENATION; HYDROLYSIS; LIQUID CHROMATOGRAPHY; LYSOSOME; MASS SPECTROMETER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TRANSPORT; TISSUE HOMOGENATE;

ALPHA-GLUCOSIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME ACTIVATORS; MOLECULAR STRUCTURE; PYRIMIDINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949654790     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.027     Document Type: Article

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