Efficacy of fixed combinations of acetylsalicyclic acid, acetaminophen and caffeine in the treatment of idiopathic headache: A review

European Journal of Neurology

Volumn 17, Issue 4, 2010, Pages 534-e25

  Anneken, K ^a,b   Evers, S ^b   Husstedt, I W ^b  

^a Dortmund Hospital   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Acetylsalicyclic acid; Combination analgesics; Headache; Headache therapy; Migraine; Tension type headache

Indexed keywords

ACETYLSALICYLIC ACID; CAFFEINE; ERGOTAMINE; IBUPROFEN; PARACETAMOL; PLACEBO; SUMATRIPTAN;

ANALGESIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG DEPENDENCE; DRUG EFFICACY; DRUG FORMULARY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; IDIOPATHIC DISEASE; MIGRAINE; PATIENT SATISFACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; TENSION HEADACHE;

EID: 77949583198     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02922.x     Document Type: Review

References (55)

1. Haag G, Evers S, May A, et al. Selbstmedikation bei Migräne und Kopfschmerz vom Spannungstyp. Evidenzbasierte Empfehlungen der Deutschen Migräne- und Kopfschmerz-Gesellschaft. Nervenheilkunde 2004 23 : 415 430.
2. Stovner LJ, Hagen K, Jensen R, et al. The global burden of headache prevalence and disability worldwide. Cephalalgia 2007 27 : 193 210.
3. Lyngberg AC, Rasmussen BK, Jorgensen T, et al. Incidence of primary headache: a Danish epidemiologic follow-up study. Am J Epidemiol 2005 11 : 1066 1073.
4. Lipton RB, Stewart WF, Ryan RE, et al. Efficacy and safety of acetaminophen, acetylsalicyclic acid, and caffeine in alleviating migraine headache pain. Three double-blind, randomised, placebo-controlled trials. Arch Neurol 1998 55 : 210 217.
5. Lipton RB, Stewart WF, Diamond S, et al. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 1998 41 : 646 657.
6. Goldstein J, Silberstein SD, Saper JR, et al. Acetaminophen, acetylsalicyclic acid, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 1998 46 : 444 453.
7. Michel P. Socioeconomic costs of headache. In : Olesen J, Telft-Hansen P, Welch KMA, eds. The Headaches. Philadelphia : Lippincott Williams & Wilkins, 2000 : 33 40.
8. ®. Wien, Klin Wochenschr 1996 108 : 219 233.
9. Aicher B, Hinz B, Sittl R, et al. Antipyretische Analgetika (AA)-Wirkstoffprofile. In : Waldvogel HH, eds. Analgetika - Antinozizeptiva - Adjuvanzien. Handbuch für Schmerzpraxis. Berlin-Heidelberg-New York : Springer, 2000 : 527 587.
10. 2 synthesis in rat microglial cells. Neuropharmacology 2000 39 : 2205 2213.
11. Fischer V. Direct electron spin resonance detection of free radical intermediates during peroxidase catalyzed oxidation of phenacetin metabolites. Chem Biol Interact 1986 60 : 115 127.
12. Fiebich BL, Candelario-Jalil E, Mantovani M, et al. Modulation of catecholamine release from rat striatal slices by the fixed combination of acetylsalicyclic acid, paracetamol and caffeine. Pharmacol Res 2006 53 : 391 396.
13. Diener HC, Pfaffenrath V, Pageler L, et al. The fixed combination of acetylsalicyclic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel-group study. Cephalalgia 2005 25 : 776 787.
14. Ward N, Whitney C, Avery D, et al. The analgesic effects of caffeine in headache. Pain 1991 44 : 151 155.
15. Migliardi JR, Armellino JJ, Friedman M, et al. Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 1994 56 : 576 586.
16. Schachtel BP, Thoden WR, Konerman JP, et al. Headache pain model for assessing and comparing the efficacy of over-the-counter analgesic agents. Clin Pharmacol Ther 1991 50 : 322 329.
17. Bromm B. Zur analgetischen Wirksamkeit von Paracetamol und Acetylsalicylsäure in experimentellem Schmerzmodell. Der Schmerz 1994 9 : 5 11.
18. Sawynok J. Pharmacological rationale for the clinical use of caffeine. Drugs 1995 49 : 37 50.
19. Mihatsch MJ, Khanlari B, Brunner FP. Obituary to analgesic nephropathy - an autopsy study. Nephrol Dial Transplant 2006 21 : 3139 3145.
20. Balk M, Bonis PAL, Moskowitz H, et al. Correlation of Quality Measures With Estimates of Treatment Effect in Meta-analyses of Randomized Controlled Trials. JAMA 2002 22 : 2973 2982.
21. Evers S, Afra J, Frese A, et al. EFNS guideline on the drug treatment of migraine - report of an EFNS task force. Eur J Neurol 2006 13 : 560 572.
22. Goldstein J, Hoffman HD, Armellino JJ, et al. Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomised, placebo-controlled studies of the combination of acetaminophen, acetylsalicyclic acid, and caffeine. Cephalalgia 1999 19 : 684 691.
23. Goldstein J, Silberstein SD, Saper JR, et al. Acetaminophen, Acetylsalicyclic acid, and Caffeine versus sumatriptan Succinate in the early treatment of migraine: results from the ASSET trial. Headache 2005 45 : 973 982.
24. Ferrari MD, Roon KI, Lipton RB, et al. Oral triptans (serotonin 5-HT (1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 2001 358 : 1668 1675.
25. Landy S. Migraine throughout the life cycle. Neurology 2004 62 : 2 8.
26. Bosse K, Kühner A. Behandlung von Kopfschmerzen verschiedenster Genese. Wirksamkeit und Verträglichkeit einer coffeinhaltigen Analgetika-Kombination - Ergebnisse einer Doppelblind-Multicenter-Studie. Kopfschmerz 1988 38 : 3879 3884.
27. Lipton RB, Baggish JS, Stewart WF, et al. Efficacy and safety of acetaminophen in the treatment of migraine: results of a randomized, double-blind, placebo-controlled, population-based study. Arch Intern Med 2000 160 : 3486 3492.
28. Silberstein SD, Armellino JJ, Hoffman HD, et al. Treatment of menstruation-associated migraine with the non-prescription combination of acetaminophen, acetylsalicyclic acid, and caffeine: results from three randomised, placebo-controlled studies. Clin Ther 1999 21 : 475 491.
29. Pini LA, Del Bene E, Zanchin G, et al. Tolerability and efficacy of a combination of paracetamol and caffeine in the treatment of tension-type headache: a randomised, double-blind, double-dummy, cross-over study versus placebo and naproxen sodium. J Headache Pain 2008 9 : 367 373.
30. Elseviers MM, De Broe ME. A long-term prospective controlled study of analgesic abuse in Belgium. Kidney Int 1995 48 : 1912 1919.
31. Pommer W, Bronder E, Greiser E, et al. Regular analgesic intake and the risk of end-stage renal failure. Am J Nephrol 1989 9 : 403 412.
32. Feinstein AR, Heinemann LAJ, Curhan GC, et al. Relationship between nonphenacetin combined analgesics and nephropathy: a review. Kidney Int 2000 58 : 2259 2264.
33. Michielsen P, DeSchepper P. Trends of analgesic nephropathy in two high-endemic regions with different legislations. J Am Soc Nephrol 2001 12 : 550 556.
34. Gaukt HM, Barrett BJ. Analgesic nephropathy. Am J Kidney Dis 1998 32 : 351 360.
35. Fort W. Schwach wirksame Analgetika - eine pharmakologische Standortbestimmung. Dtsch Apoth Ztg 1987 51 : 17 22.
36. Limmroth V, Katsarava Z, Fritsche G, et al. Features of medication overuse headache following overuse of different acute headache drugs. Neurology 2002 59 : 1011 1014.
37. Fritsche G, Diener HC. Medication overuse headache - what is new? Expert Opin Drug Saf 2002 1 : 331 338.
38. Baumgartner C, Wessely P, Bingöl C, et al. Longterm prognosis of analgesic withdrawal in patients with medication-overuse headaches. Headache 1989 29 : 510 514.
39. Haag G. Kombinationsanalgetika in der Kopfschmerztherapie. DAZ 1998 38 : 229 234.
40. Scholz E, Diener HC, Geiselhart S. Medication-overuse headache - does a critical dose exist? In : Diener HC, Wilkinson M, eds. Medication-Overuse Headache. Berlin-Heidelberg-New York : Springer, 1998 : 20 28.
41. Lane JD. Effects of brief caffeinated-beverage deprivation on mood, symptoms, and psychomotor performance. Pharmacol Biochem Behav 1997 58 : 203 208.
42. Griffiths RR, Woodson PP. Caffeine physical dependence: a review of human and laboratory animal studies. Psychopharmacology 1988 94 : 437 451.
43. Denaro CP, Brown CR, Jacob PI, et al. Effects of caffeine with repeated dosing. Eur J Clin Pharmacol 1991 40 : 273 278.
44. Denaro CP, Brown CR, Wilson M, et al. Dose-dependence of caffeine metabolism. Clin Pharmacol Ther 1990 31 : 358 369.
45. Feinstein AR, Heinemann LAJ, Dalessio D, et al. Ad hoc Review Committee: do caffeine-containing analgesics promote dependence? A review and evaluation. Clin Pharmacol Ther 1990 68 : 457 467.
46. Dews PB, Curtis GL, Hanford KJ, et al. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded experiment. J Clin Pharmacol 1999 39 : 1 12.
47. O′Brien CP. Is there an abuse potential for caffeine-containing analgesic combinations? In : Holtz A, ed. Advances in the Management of Acute Pain. International Congress and Symposium series 218. London : Royal Society of Medicine Press Limited, 1996 : 218.
48. Liebermann HR, Wurtmann RJ, Emde GG, et al. The effects of caffeine and acetylsalicyclic acid on mood and performance. J Clin Psychopharmacol 1987 7 : 315 320.
49. Stern KN, Chait LD, Johanson CE. Reinforcing and subjective effects of caffeine in normal human volunteers. Psychopharmacology 1989 98 : 81 88.
50. Fredholm BB, Bättig K, Holmen J, et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999 51 : 83 133.
51. Schoenen J, Wang W. Tension-type headache. In : Goadsby PJ, Silberstein SD, eds. Headache. Boston : Butterworth-Heinemann, 1997 : 177 200.
52. Silberstein SD. Migraine. Lancet 2004 363 : 381 391.
53. Matchar DB. Acute management of migraine. Highlights of the US Headache Consortium. Neurology 2003 60 : 21 23.
54. Gaciong Z. The real dimension of analgesic activity of aspirin. Thromb Res 2003 110 : 361 364.
55. Silberstein SD. Practice parameter: evidence based guidelines for migraine headache: (an evidence based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000 55 : 754 762.