Treatment of transected peripheral nerves with artemin improved motor neuron regeneration, but did not reduce nerve injury-induced pain behaviour

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery

Volumn 43, Issue 5, 2009, Pages 245-250

  Widenfalk, Johan ^a,b   Wu, Weiping ^b   Hao, Jingxia ^b   Person, Jonas K E ^b   Wiesenfeldt Hallin, Zsuzsanna ^b   Risling, Mrten ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Artemin; Axotomy; Fibrin sealant; GDNF; GFR; Motor neuron; Nerve injury; Nerve regeneration; Neuropathic pain; Sciatic nerve

Indexed keywords

ARTN PROTEIN, RAT; FIBRIN GLUE; NERVE GROWTH FACTOR; NERVE PROTEIN;

ANIMAL; ARTICLE; CELL COUNT; DRUG EFFECT; FEMALE; INJURY; MOTONEURON; NERVE FIBER; NERVE REGENERATION; NEURALGIA; PERIPHERAL NERVE; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; AXONS; CELL COUNT; FEMALE; FIBRIN TISSUE ADHESIVE; MOTOR NEURONS; NERVE GROWTH FACTORS; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURALGIA; PERIPHERAL NERVES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77949559157     PISSN: 02844311     EISSN: 16512073     Source Type: Journal    
DOI: 10.3109/02844310903259082     Document Type: Article

References (16)

1. Abrams M, Widenfalk J. Emerging strategies to promote improved functional outcome after peripheral nerve injury. Restor Neurol Neurosci 2005;/23:/367-82.
2. Boyd JG, Gordon T. Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol 2003;/27:/277-324.
3. Baloh RH, Tansey MG, Lampe PA, et al. Artemin, a novel member of the gdnf ligand family, supports peripheral and central neurons and signals through the gfralpha3-ret receptor complex. Neuron 1998;/21:/1291-302.
4. Widenfalk J, Tomac A, Lindqvist E, Hoffer B, Olson L. Gfralpha-3, a protein related to gfralpha-1, is expressed in developing peripheral neurons and ensheathing cells. Eur J Neurosci 1998;/10:/1508-17.
5. Naveilhan P, Baudet C, Mikaels A, Shen L, Westphal H, Ernfors P. Expression and regulation of gfralpha3, a glial cell line-derived neurotrophic factor family receptor. Proc Natl Acad Sci U S A 1998;/95:/1295-300.
6. Gardell LR, Wang R, Ehrenfels C, et al. Multiple actions of systemic artemin in experimental neuropathy. Nat Med 2003;/9:/1383-9.
7. Malin SA, Molliver DC, Koerber HR, et al. Glial cell linederived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J Neurosci 2006;/26:/8588-99.
8. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946;/94:/239-47.
9. Wiesenfeld Z, Hallin RG. Influence of nerve lesions, strain differences and continuous cold stress on chronic pain behavior in rats. Physiol Behav 1981;/27:/735-40.
10. Jubran M, Widenfalk J. Repair of peripheral nerve transections with fibrin sealant containing neurotrophic factors. Exp Neurol 2003;/181:/204-12.
11. Landegren T, Risling M, Brage A, Persson JK. Long-term results of peripheral nerve repair: a comparison of nerve anastomosis with ethyl-cyanoacrylate and epineural sutures. Scand J Plast Reconstr Surg Hand Surg 2006;/40:/65-72.
12. de Medinaceli L, Freed WJ, Wyatt RJ. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 1982;/77:/634-43.
13. Carlton JM, Goldberg NH. Quantitating integrated muscle function following reinnervation. Surg Forum 1986;/37:/ 611-2.
14. Brown CJ, Mackinnon SE, Evans PJ, et al. Self-evaluation of walking-track measurement using a sciatic function index. Microsurgery 1989;/10:/226-35.
15. Funakoshi H, Frisén J, Barbany G, et al. Differential expression of mrnas for neurotrophins and their receptors after axotomy of the sciatic nerve. J Cell Biol 1993;/123:/ 455-65.
16. Widenfalk J, Lundstromer K, Jubran M, Brene S, Olson L. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J Neurosci 2001;/21:/3457-75.