Characterization of a nose-only inhalation exposure system for hydrocarbon mixtures and jet fuels

Inhalation Toxicology

Volumn 22, Issue 5, 2010, Pages 382-393

  Martin, Sheppard A ^a   Tremblay, Raphael T ^a   Brunson, Kristyn F ^a   Kendrick, Christine ^a   Fisher, Jeffrey W ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Inhalation; Jet fuel; JP 8; Nebulizer; Nose only; S 8

Indexed keywords

1,2,4 TRIMETHYLBENZENE; 2 METHYLNAPHTHALENE; ADSORBENT; DECANE; DODECANE; ETHYLBENZENE; FUEL; HYDROCARBON; META XYLENE; NAPHTHALENE; NONANE; OCTANE; PENTADECANE; TETRADECANE; TOLUENE; TRIDECANE; UNCLASSIFIED DRUG; UNDECANE;

AEROSOL; AIRCRAFT; ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); DESORPTION; EXPOSURE; GAS CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; NEBULIZER; PARTICLE SIZE; PRIORITY JOURNAL; VAPOR;

AEROSOLS; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROCARBONS; INHALATION EXPOSURE; KEROSENE; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; RATS;

RODENTIA;

EID: 77949553092     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958370903456645     Document Type: Article

References (53)

1. Acros Organics N.V. (2000). Material Safety Data Sheet Naphthalene, Scintillation Grade 99+%. [Online] Available at: http://avogadro.chem.iastate. edu/ MSDS/naphthalene.htm.
2. Baldwin C, Figueredo A, Wright L, Wong S, Witten M. 2007. Repeated aerosolvapor JP-8 jet fuel exposure affects neurobehavior and neurotransmitter levels in a rat model. J Toxicol Environ Health A 70:1203-1213.
3. Brockman J. 1993. Sampling and transport of aerosols. In:Baron P, Willeke K, eds. Aerosol Measurement: Principle, Techniques and Applications. New York: Van Nostrand Reinhold, 103.
4. Campbell J Jr, Fisher J. 2007. A PBPK modeling assessment of the competitive metabolic interactions of JP-8 vapor with two constituents, m-xylene and ethylbenzene. Inhal Toxicol 19: 265-273.
5. Chatterjee A, Babu R, Klausner M, Singh M. 2006. In vitro and in vivo comparison of dermal irritancy of jet fuel exposure using EpiDerm™?(EPI- 200) cultured human skin and hairless rats. Toxicol Lett 167: 85-94.
6. Chavanne B. 2007. USAF wants fleet certified for synthetic fuel blend by 2011. Aviation Week: Aerospace Daily and Defense Report [online]. Available at: http://www.aviationweek.com/aw/generic/story-channel. jsp?channel= defense&id=news/FUEL102907.xml. Accessed 29 October 2007.
7. ChemicalBook Inc. (2008a). n-Tridecane (629-50-5). [Online] Available at: http:// www.chemicalbook.com/ProductMSDSDetailCB5854626-EN.htm.
8. ChemicalBook Inc. (2008b). 2-Methylnaphthalene (91-57-6). [Online] Available at: http://www.chemicalbook.com/ProductMSDSDetailCB3232426-EN.htm.
9. Cox SS, Zhao D, Little JC. (2001). Measuring partition and diffusion coefficients for volatile organic compounds in vinyl flooring. Atmos Environ 35: 3823-3830.
10. Dennis JH, Stenton SC, Beach JR, Avery AJ, Walters EH, Hendrick DJ. 1990. Jet and ultrasonic nebuliser output: Use of a new method for direct measurement of aerosol output. Thorax 45: 728-32..
11. Dietzel K, Campbell J, Bartlett M, Witten M, Fisher J. 2005. Validation of a gas chromatography/mass spectrometry method for the quantification of aerosolized Jet Propellant 8. J Chromatogr A 1093: 11-20.
12. Fechter L, Gearhart C, Fulton S, Campbell J, Fisher J, Na K, Cocker D, Nelson-Miller A, Moon P, Pouyatos B. 2007. JP-8 jet fuel can promote auditory impairment resulting from subsequent noise exposure in rats. Toxicol Sci 98: 510-525.
13. Harris D, Sakiestewa D, Robledo R, Witten M. 1997. Immunotoxicological effects of JP-8 jet fuel exposure. Toxicol Ind Health, 13, 43-55.
14. Harris D, Sakiestewa D, Robledo R, Young R, Witten M. 2000. Effects of shortterm JP-8 jet fuel exposure on cell-mediated immunity. Toxicol Ind Health 16: 78.
15. Hemighaus G. 2007. Synthetic fuels for aviation. ASTM Stand News [online]. Available at: http://www.astm.org/SNEWS/APRIL-2007/p-hemighaus- apr07.html. Accessed 17 July 2009.
16. Hernandez SAJ. 2007. SECAF certifies Fischer-Tropsch synthetic fuel blends for B-52H. Air Force Materiel Command-News [online]. Available at: http://www.afmc.af.mil/news/story.asp?id=123063849. Accessed 14 June 2009.
17. Jaeger RJ. 1994. Modular reversible-flow-past nasopulmonary respiratory dosing system for laboratory animals. Patent No. 5297502.
18. Keystone Automotive Industries. (2004). Material Safety Data Sheet. Product Name: 2.1 VOC Key Euro Clear Slow Activator. [Online] Available at: http://www.keystone-auto.com/bodyshops/msds/msds-keyC48.pdf.
19. Knave B, Persson H, Goldberg JM, Westerholm P. 1976. Long-term exposure to jet fuel: An investigation on occupationally exposed workers with special reference to the nervous system. Scand J Work Environ Health 2: 152-164.
20. Knave B, Olson B, Elofsson S, Gamberale F, Isaksson A, Mindus P, Persson H, Struwe G, Wennberg A, Westerholm P. 1978. Long-term exposure to jet fuel. II. A cross-sectional epidemiologic investigation on occupationally exposed industrial workers with special reference to the nervous system. Scand J Work Environ Health 4: 19-45.
21. Knave B, Mindus P, Struwe G. 1979. Neurasthenic symptoms in workers occupationally exposed to jet fuel. Acta Psychiatr Scand, 60, 39-49.
22. Mattie D, Alden C, Newell T, Gaworski C, Flemming C. 1991. A 90-day continuous vapor inhalation toxicity study of JP-8 jet fuel followed by 20 or 21 months of recovery in Fischer 344 rats and C57BL/6 mice. Toxicol Pathol 19: 77-87.
23. May K. 1973. The Collison nebulizer: description, performance and application. J. Aerosol Sci 4: 235-243.
24. McCallion O, Taylor K, Bridges P, Thomas M, Taylor A. 1996. Jet nebulisers for pulmonary drug delivery. Int J Pharm 130: 1-11.
25. McDougal J, Garrett C, Amato C, Berberich S. 2007. Effects of brief cutaneous JP-8 jet fuel exposures on time course of gene expression in the epidermis. Toxicol Sci 95: 495-510.
26. Monteiro-Riviere N, Inman A, Riviere J. 2001. Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels. J Appl Toxicol 21: 485-494.
27. National Research Council of the National Academies. 2003. Toxicologic Assessment of Jet-Propulsion Fuel 8. Washington, DC: The National Academies Press.
28. Nordholm A. 1999. Repeated exposure of rats to JP-4 vapor induces changes in neurobehavioral capacity and 5-HT/5-HIAA levels. J Toxicol Environ Health A 56: 471-499.
29. Osgar M. 2009. Personal Communication. Savillex Corporation, Minnetonka MN.
30. Perleberg U, Keys D, Fisher J. 2004. Development of a physiologically based pharmacokinetic model for decane, a constituent of jet propellent-8. Inhal Toxicol 16: 771-783.
31. Porter H. 1990. Aviators intoxicated by inhalation of JP-5 fuel vapors. Aviat Space Environ Med 61: 654-656.
32. Potter TL, Simmons KE. (1998). Total Petroleum Hydrocarbon Criteria Working Group Series Volume2: Composition of Petroleum Mixtures. Amherst Scientific Publishing. [Online] Available at: http://www. aehs.com/publications/ catalog/contents/tph.htm. Accessed August 3, 2009.
33. Ramos G, Nghiem D, Walterscheid J, Ullrich S. 2002. Dermal application of jet fuel suppresses secondary immune reactions. Toxicol Appl Pharmacol 180: 136-144.
34. Rau J. 2002. Design principles of liquid nebulization devices currently in use. Discussion. Respir Care 47: 1257-1275.
35. Reboulet J. 2006. Personal communication. Dayton, OH: Wright Patterson Air Force.
36. Rhodes A, LeMasters G, Lockey J, Smith J, Yiin J, Egeghy P, Gibson R. 2003. The effects of jet fuel on immune cells of fuel system maintenance workers. J Occup Environ Med 45: 79-86.
37. Ritchie G, Rossi J, Nordholm A, Still K, Carpenter R, Wenger G, Wright D. 2001. Effects of repeated exposure to JP-8 jet fuel vapor on learning of simple and difficult operant tasks by rats. J Toxicol Environ Health A 64: 385-415.
38. Robledo R, Witten M. 1998. Acute pulmonary response to inhaled JP-8 jet fuel aerosol in mice. Inhal Toxicol 10: 531-553.
39. Robledo R, Young R, Lantz R, Witten M. 2000. Short-term pulmonary response to inhaled JP-8 jet fuel aerosol in mice. Toxicol Pathol 28: 656.
40. Rossi J, Nordholm A, Carpenter R, Ritchie G, Malcomb W. 2001. Effects of repeated exposure of rats to JP-5 or JP-8 jet fuel vapor on neurobehavioral capacity and neurotransmitter levels. J Toxicol Environ Health A 63: 397-428.
41. Salem H, Katz S. 2006. Inhalation Toxicology. Boca Raton, FL: CRC Press.
42. Savillex. 2005. C-Flow Nebulizer Installation Details. 300023. Minnetonka, MN: Savillex, Inc.
43. ScienceLab.com Inc. (2008). Material Safety Data Sheet. [Online] Available at: http://www.sciencelab.com.
44. Smith L, Bhattacharya A, Lemasters G, Succop PE II, Medvedovic M, Joyce J. 1997. Effect of chronic low-level exposure to jet fuel on postural balance of US Air Force Personnel. J Occup Environ Med 39: 623-632.
45. The Physical and Theoretical Chemistry Laboratory Oxford University. (2009). MSDS (Material Safety Data Sheet) Information. [Online] Available at: http://msds.chem.ox.ac.uk/.
46. Tillery MI, Wood GO, Ettinger HJ. 1976. Generation and characterization of aerosols and vapors for inhalation experiments. Environ Health Perspect 16: 25-40.
47. Tremblay R, Martin S, Fechter L, Fisher J. 2008. A novel method for the chemical chracterization of generated jet fuel vapor and aerosol for animal studies, 1100. Toxicologist 102(S-1).
48. Tremblay R, Martin S, Fisher J. 2009. Novel characterization of the aerosol and gas phase composition for aerosolized jet fuel atmospheres. Inhal Toxicol 22:this issue.
49. Tremblay R, Martin S, Fisher J. Submitted. In:Witten M, Ritchie G, Zeiger E, eds. Jet Fuel Toxicology. London: Taylor & Francis, in press.
50. Ullrich S. 1999. Dermal application of JP-8 jet fuel induces immune suppression. Toxicol Sci 52: 61-67.
51. Whitman F, Hinz J. 2001. Sensory irritation study in mice: JP-4, JP-8, JP-8 + 100. IERA-RS-BR-SR-2001-0005. Brooks City-Base, TX: Risk Assessment Division, Air Force Institute for Operational Health. IERA-RS-BR-SR- 2001-10005 Brooks City-Base, TX: Risk Assessment Division AFIfOH.
52. Whitman F, Hinz J. 2004. Sensory irritation study in mice: JP-5, JP-TS, JP-7, DFM, JP-10. IOH-RS-BR-SR-2004-0001. Brooks City-Base, TX: Risk Assessment Division, Air Force Institute for Operational Health. IERARS- BR-SR-2004-10001 Brooks City-Base, TX: Risk Assessment Division AFIfOH.
53. Wolff R, Niven R. 1994. Generation of aerosolized drugs. J Aerosol Med 7: 89-106.