Clinical application of ischemic preconditioning in the elderly

Dose-Response

Volumn 8, Issue 1, 2010, Pages 34-40

  Abete, Pasquale ^a   Cacciatore, Francesco ^b   Testa, Gianluca ^a,c,d   Della Morte, David ^a,e   Galizia, Gianluigi ^a,f   Ferrara, Nicola ^b,d   Rengo, Franco ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRCCS   (Italy)

^c CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^d UNIVERSITY OF MOLISE   (Italy)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; Hormesis; Lifestyles; Preconditioning

Indexed keywords

EID: 77949543954     PISSN: None     EISSN: 15593258     Source Type: Journal    
DOI: 10.2203/dose-response.09-023.Abete     Document Type: Article

References (37)

1. Abete P, Ferrara N, Cioppa A, Ferrara P, Bianco S, Calabrese C, Cacciatore, F, Longobardi G, Rengo F. 1996. Preconditioning does not prevent post-ischemic dysfunction in aging heart. J Am Coll Cardiol 27:1777-1786.
2. Abete P, Ferrara N, Cacciatore F, Madrid A, Bianco S, Calabrese C, Napoli C, Scognamiglio P, Bollella O, Cioppa A, Longobardi G, Rengo F. 1997. Angina-induced protection against myocardial infarction in adult and senescent patients. A loss of preconditioning mechanism in aging heart? J Am Coll Cardiol 30:947-954.
3. Abete P, Calabrese C, Ferrara N, Cioppa A, Pisanelli P, Cacciatore F, Longobardi G, Napoli C, Rengo F. 2000. Exercise training restores ischemic preconditioning in the aging heart. J Am Coll Cardiol 36:643-650.
4. Abete P, Ferrara N, Cacciatore F, Sagnelli E, Manzi M, Carnovale V, Calabrese C, de Santis D, Testa G, Longobardi G, Napoli C, Rengo F. 2001. High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients. J Am Coll Cardiol 38:1357-1365.
5. Abete P, Testa G, Ferrara N, De Santis D, Capaccio P, Viati L, Calabrese C, Cacciatore F, Longobardi G, Condorelli M, Napoli C, Rengo F. 2002. Cardioprotective effect of IP is preserved in foodrestricted senescent rats. Am J Physiol 282:H1978-H1987.
6. Abete P, Cacciatore F, Ferrara N, Calabrese C, de Santis D, Testa G, Galizia G, Del Vecchio S, Leosco D, Condorelli M, Napoli C, Rengo F. 2003. Body mass index and preinfarction angina in elderly patients with acute myocardial infarction. Am J Clin Nutr 78:796-801.
7. Abete P, Testa G, Galizia G, Mazzella F, Della Morte D, de Santis D, Calabrese C, Cacciatore F, Gargiulo G, Ferrara N, Rengo G, Sica V, Napoli C, Rengo F. 2005. Tandem action of exercise training and food restriction completely preserves IP in the aging heart. Exp Gerontol 40:43-50.
8. Abete P, Cacciatore F, Della-Morte D, Mazzella F, Testa G, Galizia G, De Santis D, Longobardi G, Ferrara N, Rengo F. 2009. Joint effect of physical activity and body mass index on mortality for acute myocardial infarction in the elderly: role of preinfarction angina as equivalent of IP. Eur J Cardiovasc Prev Rehabil 16:73-79.
9. Andreotti F, Pasceri V, Hackett DR, Davies GJ, Haider AW, Maseri A. 1996. Preinfarction angina as a predictor of more rapid coronary thrombolysis in patients with acute myocardial infarction. N Engl J Med 334:7-12.
10. Bartling B, Friedrich I, Silber RE, Simm A. 2003 Ischemic preconditioning is not cardioprotective in senescent human myocardium. Ann Thorac Surg 76:105-111. [PubMed: 12842522]
11. Dawson R Jar, Meldrum MJ. 1992. Norepinephrine content in cardiovascular tissue from the aged Fisher 344 rat. Gerontology 38: 185-191.
12. Downey JM, Davis AM, Cohen MV. 2007. Signaling pathways in ischemic preconditioning. Heart Fail Rev 12:181-188.
13. Fenton RA, Dickson EW, Dobson JG Jr. 2005. Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart. Life Sci 77:3375-3388.
14. Fenton RA, Dickson EW, Meyer TE, Dobson JG Jr. 2000. Aging reduces the cardioprotective effect of ischemic preconditioning in the rat heart. J Mol Cell Cardiol 32:1371-1375.
15. Halestrap AP, Clarke SJ, Khaliulin I. 2007. The role of mitochondria in protection of the heart by preconditioning. Biochim Biophys Acta 1767:1007-1031.
16. Hausenloy DJ, Ong SB, Yellon DM. 2009. The mitochondrial permeability transition pore as a target for preconditioning and postconditioning. Basic Res Cardiol 104:189-202.
17. Heusch G, Boengler K, Schulz R. 2008. Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation 118:1915-1919.
18. Ishihara M, Sato H, Tateishi H, Kawagoe T, Shimatani Y, Ueda K, Noma K, Yumoto A, Nishioka K. 2000. Beneficial effect of prodromal angina pectoris is lost in elderly patients with acute myocardial infarction. Am Heart J 139:881-888.
19. Jahangir A, Sagar S, Terzic A. 2007. Aging and cardioprotection. J Appl Physiol 103:2120-2128.
20. Juhaszova M, Rabuel C, Zorov DB, Lakatta EG, Sollott SJ. 2005. Protection in the aged heart: preventing the heart-break of old age? Cardiovasc Res 66:233-244.
21. Kloner RA, Shook T, Przyklenk K, Davis VG, Junio L, Matthews RV, Burstein S, Gibson CM, Poole WK, Cannon CP, McCabe CH, Braunwald E. 1995. Previous angina alters in-hospital outcome in TIMI 4: a clinical correlate to preconditioning? Circulation 91:37-47.
22. Lakatta EG, Sollott SJ. 2002. The "heartbreak" of older age. Mol Interv 2:431-446.
23. Lee TM, Su SF, Chou TF, Lee YT, Tsai CH. 2002. Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty. Circulation 105:334-340.
24. Longobardi G, Abete P, Ferrara N, Papa A, Rosiello R, Furgi G, Calabrese C, Cacciatore F, Rengo F. 2000. "Warm-up" phenomenon in adult and elderly patients with coronary artery disease: further evidence of the loss of "IP" in the aging heart. J Gerontol A Biol Sci Med Sci 55:M124-M129.
25. Mazzeo RS and Horvarth SM. 1987. A decline in myocardial and hepatic norepinephrine turnover with age in Fisher 344 rats. Am J Physiol 252: E762-E764.
26. McCully JD, Uematsu M, Parker RA, Levitsky S. 1998. Adenosine-enhanced IP provides enhanced cardioprotection in the aged heart. Ann Thorac Surg 66:2037-2043.
27. Murry CE, Sennings RB, Reimer KA. 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124-1136.
28. Napoli C, Liguori A, Cacciatore F, Rengo F, Ambrosio G, Abete P. 1999. "Warm-up" phenomenon detected by electrocardiographic ambulatory monitoring in adult and older patients. J Am Geriatr Soc 47:1114-1117.
29. Napoli C, Pinto A, Cirino G. 2000. Pharmacological modulation, preclinical studies, and new clinical features of myocardial ischemic preconditioning. Pharmacol Ther 88:311-331.
30. Ottani F, Galvani M, Ferrini D, Sorbello F, Limonetti P, Pantoli D, Rusticali F. 1995. Prodromal angina limits infarct size. A role of ischemic preconditioning. Circulation 91:291-297.
31. Peart JN, Gross ER, Headrick JP, Gross GJ. 2007. Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. J Mol Cell Cardiol 42:972-980.
32. Pepe S. 2001. Dysfunctional IP mechanisms in aging. Cardiovasc Res 49:11-14.
33. Tani M, Honma Y, Hasegawa H, Tamaki K. 2001. Direct activation of mitochondrial K [ATP] channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts. Cardiovasc Res 49:56-68.
34. Tani M, Suganuma Y, Hasegawa H, Shinmura K, Hayashi Y, Guo X, Nakamura Y. 1997. Changes in ischemic tolerance and effects of IP in middle-aged rat hearts. Circulation 95:2559-2566.
35. Wu ZK, Pehkonen E, Laurikka J, Kaukinen L, Honkonen EL, Kaukinen S, Laippala P, Tarkka MR. 2001. The protective effects of preconditioning decline in aged patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 122:972-978.
36. Yellon DM, Downey JM. 2003. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 83:1113-1151.
37. Zorov DB, Juhaszova M, Yaniv Y, Nuss HB, Wang S, Sollott SJ. 2009. Regulation and pharmacology of the mitochondrial permeability transition pore. Cardiovasc Res in press.