Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins

Kidney International

Volumn 77, Issue 7, 2010, Pages 601-608

  Hsu, Yu Juei ^a,b   Dimke, Henrik ^a   Schoeber, Joost P H ^a   Hsu, Shih Che ^b   Lin, Shih Hua ^b   Chu, Pauling ^b   Hoenderop, Joost G J ^a   Bindels, René J M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Androgens; Calciotropic hormones; Orchidectomy; TRPV5

Indexed keywords

ANDROGEN; ANDROSTANOLONE; CALBINDIN; CALCITRIOL; ESTROGEN; PARATHYROID HORMONE; TESTOSTERONE; VANILLOID RECEPTOR 5;

ANDROGEN DEFICIENCY; ANIMAL EXPERIMENT; ARTICLE; CALCIUM ABSORPTION; CALCIUM TRANSPORT; CALCIUM URINE LEVEL; CONTROLLED STUDY; ESTROGEN BLOOD LEVEL; FEMALE; HORMONE BLOOD LEVEL; HYPOCALCIURIA; KIDNEY TUBULE ABSORPTION; MALE; MOUSE; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RECEPTOR POTENTIAL; REGULATORY MECHANISM; SEX DIFFERENCE; URINARY EXCRETION; VITAMIN BLOOD LEVEL;

EID: 77949542230     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.522     Document Type: Article

References (27)

1. Morgan B, Robertson WG. The urinary excretion of calcium. An analysis of the distribution of values in relation to sex, age and calcium deprivation. Clin Orthop Relat Res 1974; 101: 254-267.
2. Davis RH, Morgan DB, Rivlin RS. The excretion of calcium in the urine and its relation to calcium intake, sex and age. Clin Sci 1970; 39: 1-12.
3. Van Abel M, Hoenderop JG, Dardenne O et al. 1,25-Dihydroxyvitamin D(3)-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney. J Am Soc Nephrol 2002; 13: 2102-2109.
4. Stefani S, Aguiari GL, Bozza A et al. Androgen responsiveness and androgen receptor gene expression in human kidney cells in continuous culture. Biochem Mol Biol Int 1994; 32: 597-604.
5. Sabolic I, Asif AR, Budach WE et al. Gender differences in kidney function. Pflugers Arch 2007; 455: 397-429.
6. Hoenderop JG, Nilius B, Bindels RJ. Calcium absorption across epithelia. Physiol Rev 2005; 85: 373-422.
7. Bindels RJ. Calcium handling by the mammalian kidney. J Exp Biol 1993; 184: 89-104.
8. Bindels RJ. Molecular pathophysiology of renal calcium handling. Kidney Blood Press Res 2000; 23: 183-184.
9. Hoenderop JG, Willems PH, Bindels RJ. Toward a comprehensive molecular model of active calcium reabsorption. Am J Physiol Renal Physiol 2000; 278: F352-F360.
10. Hoenderop JG, Muller D, Van Der Kemp AW et al. Calcitriol controls the epithelial calcium channel in kidney. J Am Soc Nephrol 2001; 12: 1342-1349.
11. 2+) transport proteins by parathyroid hormone. Kidney Int 2005; 68: 1708-1721.
12. Hoenderop JG, Bindels RJ. Calciotropic and magnesiotropic TRP channels. Physiology (Bethesda) 2008; 23: 32-40.
13. Mauras N, Hayes VY, Vieira NE et al. Profound hypogonadism has significant negative effects on calcium balance in males: a calcium kinetic study. J Bone Miner Res 1999; 14: 577-582.
14. Chen Z, Vaughn DA, Fanestil DD. Influence of gender on renal thiazide diuretic receptor density and response. J Am Soc Nephrol 1994; 5: 1112-1119.
15. Nyomba BL, Bouillon R, De Moor P. Evidence for an interaction of insulin and sex steroids in the regulation of vitamin D metabolism in the rat. J Endocrinol 1987; 115: 295-301.
16. Hope WG, Ibarra MJ, Thomas ML. Testosterone alters duodenal calcium transport and longitudinal bone growth rate in parallel in the male rat. Proc Soc Exp Biol Med 1992; 200: 536-541.
17. Takeda H, Chodak G, Mutchnik S et al. Immunohistochemical localization of androgen receptors with mono-and polyclonal antibodies to androgen receptor. J Endocrinol 1990; 126: 17-25.
18. Khosla S, Melton 3rd LJ, Atkinson EJ et al. Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 2001; 86: 3555-3561.
19. Riggs BL, Khosla S, Melton 3rd LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002; 23: 279-302.
20. Syed F, Khosla S. Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun 2005; 328: 688-696.
21. Nolan LA, Levy A. The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity. J Endocrinol 2006; 188: 387-396.
22. Alexander RT, Woudenberg-Vrenken TE, Buurman J et al. Klotho prevents renal calcium loss. J Am Soc Nephrol 2009; 20: 2371-2379.
23. van Abel M, Hoenderop JG, van der Kemp AW et al. Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection. Am J Physiol Gastrointest Liver Physiol 2003; 285: G78-G85.
24. Van Baal J, Yu A, Hartog A et al. Localization and regulation by vitamin D of calcium transport proteins in rabbit cortical collecting system. Am J Physiol 1996; 271: F985-F993.
25. 2+) channel in rabbit kidney and intestine. J Am Soc Nephrol 2000; 11: 1171-1178.
26. 2+ transport in primary cultures of rabbit kidney CCD: stimulation by 1,25-dihydroxyvitamin D3 and PTH. Am J Physiol 1991; 261: F799-F807.
27. 2+ reabsorption is mediated by apical A1 receptors in rabbit cortical collecting system. Am J Physiol 1998; 274: F736-F743.