A comparison of methohexital versus etomidate for endotracheal intubation of critically ill patients

American Journal of Critical Care

Volumn 19, Issue 1, 2010, Pages 48-54

  Diaz Guzman, Enrique ^a,b   Mireles Cabodevila, Eduardo ^e   Heresi, Gustavo A ^c   Bauer, Seth R ^d   Arroliga, Alejandro C ^f  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Pulmonary Section   (United States)

^c Respiratory Institute   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^f TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETOMIDATE; INTRAVENOUS ANESTHETIC AGENT; METHOHEXITAL;

ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; CONSCIOUS SEDATION; CRITICAL ILLNESS; ENDOTRACHEAL INTUBATION; FEMALE; HUMAN; INTENSIVE CARE UNIT; MALE; METHODOLOGY; MIDDLE AGED; RETROSPECTIVE STUDY; TREATMENT OUTCOME;

ANESTHETICS, INTRAVENOUS; COHORT STUDIES; CONSCIOUS SEDATION; CRITICAL ILLNESS; ETOMIDATE; FEMALE; HUMANS; INTENSIVE CARE UNITS; INTUBATION, INTRATRACHEAL; MALE; METHOHEXITAL; MIDDLE AGED; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 77949535943     PISSN: 10623264     EISSN: None     Source Type: Journal    
DOI: 10.4037/ajcc2010562     Document Type: Article

References (25)

1. Walz JM, Zayaruzny M, Heard SO. Airway management in critical illness. Chest. 2007;131:608-620.
2. Williams EL. Changes in haemodynamic variables with thiopentone, methohexitone, propofol and etomidate. Br J Anaesth. 1993;70:115-116.
3. Reynolds SF, Heffner J. Airway management of the critically ill patient: rapid-sequence intubation. Chest. 2005;127:1397-1412.
4. Oglesby AJ. Should etomidate be the induction agent of choice for rapid sequence intubation in the emergency department? Emerg Med J. 2004;21:655-659.
5. Zed PJ, Abu-Laban RB, Harrison DW. Intubating conditions and hemodynamic effects of etomidate for rapid sequence intubation in the emergency department: an observational cohort study. Acad Emerg Med. 2006;13:378-383.
6. Schenarts CL, Burton JH, Riker RR. Adrenocortical dysfunction following etomidate induction in emergency department patients. Acad Emerg Med. 2001;8:1-7.
7. den Brinker M, Joosten KF, Liem O, et al. Adrenal insufficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. J Clin Endocrinol Metab. 2005;90:5110-5117.
8. Vinclair M, Broux C, Faure P, et al. Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med. 2008;34:714-719.
9. Hildreth AN, Mejia VA, Maxwell RA, Smith PW, Dart BW, Barker DE. Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study. J Trauma. 2008;65:573-579.
10. Annane D. ICU physicians should abandon the use of etomidate! Intensive Care Med. 2005;31:325-326.
11. Murray H, Marik PE. Etomidate for endotracheal intubation in sepsis: acknowledging the good while accepting the bad. Chest. 2005;127:707-709.
12. Morris C, McAllister C. Etomidate for emergency anaesthesia; mad, bad and dangerous to know? Anaesthesia. 2005;60:737-740.
13. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358: 111-124.
14. Miller RD. Miller's Anesthesia. 6th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2005.
15. Roberts JR, Hedges JR. Clinical Procedures in Emergency Medicine. 4th ed. Philadelphia, PA: WB Saunders; 2004.
16. Lerman B, Yoshida D, Levitt MA. A prospective evaluation of the safety and efficacy of methohexital in the emergency department. Am J Emerg Med. 1996;14:351-354.
17. Zink BJ, Darfler K, Salluzzo RF, Reilly KM. The efficacy and safety of methohexital in the emergency department. Ann Emerg Med. 1991;20:1293-1298.
18. Sivilotti ML, Filbin MR, Murray HE, Slasor P, Walls RM. Does the sedative agent facilitate emergency rapid sequence intubation? Acad Emerg Med. 2003;10:612-620.
19. Adnet F, Borron SW, Racine SX, et al. The intubation difficulty scale (IDS): proposal and evaluation of a new score characterizing the complexity of endotracheal intubation.Anesthesiology. 1997;87:1290-1297.
20. Mort TC. Complications of emergency tracheal intubation: hemodynamic alterations-part I. J Intensive Care Med. 2007;22:157-165.
21. Sacchetti A. Etomidate: not worth the risk in septic patients. Ann Emerg Med. 2008;52:14-16.
22. Austin T, Vilke GM, Nyheim E, Kelly D, Chan TC. Safety and effectiveness of methohexital for procedural sedation in the emergency department. J Emerg Med. 2003;24:315-318.
23. Lichtenberg ES, Hill LJ, Howe M, Heber W, Peipert JF. A randomized comparison of propofol and methohexital as general anesthetics for vacuum abortion. Contraception. 2003;68:211-217.
24. Jaber S, Amraoui J, Lefrant JY, et al. Clinical practice and risk factors for immediate complications of endotracheal intubation in the intensive care unit: a prospective, multiple-center study. Crit Care Med. 2006;34:2355-2361.
25. Davis DP, Kimbro TA, Vilke GM. The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension. Prehosp Emerg Care. 2001;5:163-168.