Nanostructure of collagen fibrils in human nucleus pulposus and its correlation with macroscale tissue mechanics

Journal of Orthopaedic Research

Volumn 28, Issue 4, 2010, Pages 497-502

  Aladin, Darwesh M K ^a   Cheung, Kenneth M C ^a   Ngan, Alfonso H W ^b   Chan, Danny ^a   Leung, Victor Y L ^a   Lim, Chwee Teck ^c   Luk, Keith D K ^a   Lu, William W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Atomic force microscope; Collagen fibril; Human intervertebral disc; Nanostructure; Nucleus pulposus

Indexed keywords

COLLAGEN FIBRIL; COLLAGEN TYPE 2; NANOMATERIAL; FIBRILLAR COLLAGEN; NANOFIBER;

ADOLESCENT; ADULT; ARTICLE; ATOMIC FORCE MICROSCOPY; CHILD; COMPRESSION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MECHANICS; NUCLEUS PULPOSUS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRESSURE; PRIORITY JOURNAL; SCHOOL CHILD; SCOLIOSIS; SPINE SURGERY; SWELLING; TISSUE; TISSUE STRUCTURE; YOUNG MODULUS; BIOMECHANICS; CHEMISTRY; COMPRESSIVE STRENGTH; INTERVERTEBRAL DISK; SCANNING ELECTRON MICROSCOPY; THREE DIMENSIONAL IMAGING; ULTRASTRUCTURE;

ADOLESCENT; BIOMECHANICS; CHILD; COMPRESSIVE STRENGTH; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBRILLAR COLLAGENS; HUMANS; IMAGING, THREE-DIMENSIONAL; INTERVERTEBRAL DISK; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; NANOFIBERS; PRESSURE; YOUNG ADULT;

EID: 77949505319     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21010     Document Type: Article

References (33)

1. Eyre DR, Muir H. 2003. Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus. Biochem J 157:267-270.
2. Scott JE, Bosworth TR, et al. 1994. The chemical morphology of age-related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposus and annulus fibrosus. J Anat 184:73-82.
3. Duance VC, Crean JKG, Sims TJ, et al. 1998. Changes in collagen cross-linking in degenerative disc disease and scoliosis. Spine 23:2545-2551.
4. Wognum S, Huyghe JMRJ, Baaijens FPT. 2006. Influence of osmotic pressure changes on the opening of existing cracks in two intervertebral disc models. Spine 31:1783- 1788.
5. Urban JP, Roberts S. 1995. Development and degeneration of the intervertebral discs. Mol Med Today 1:329-335.
6. Battie MC, Videman T, Parent E. 2004. Lumbar disc degeneration: epidemiology and genetic influences. Spine 29:2679-2690.
7. Chan D, Song Y, Sham P. 2006. Genetics of disc degeneration. Eur Spine J 15:317-325.
8. Cheung KMC, Chan D, Karppinen J. 2006. Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine 31:1143-1148.
9. Aladin KDM, Cheung KMC, Chan D, et al. 2007. Expression of the Trp2 allele of COL9A2 is associated with alterations in the mechanical properties of human intervertebral discs. Spine (ISSLS Prize Issue) 32:2820-2826.
10. Roeder BA, Kokini K, Sturgis JE, et al. 2002. Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructure. Trans ASME 124:214-222.
11. Johannessen W, Elliott MD. 2005. Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine 30:E724-E729.
12. Périé D, MacLean JJ, Owen JP, et al. 2006. Correlating material properties with tissue composition in enzymatically digested bovine annulus fibrosus and nucleus pulposus tissue. Ann Biomed Eng 34:769-777.
13. Fartzl P, Weinkamer R. 2007. Nature's hierarchical materials. Prog Mater Sci 52:1263-1334.
14. Merola A, Castro A, Enguidanos TR, et al. 2003. Biomechanics of intervertebral disk. In: Dewald RL, editor. Spinal deformities - the comprehensive text. New York: Thieme. p 172-175.
15. Buehler MJ. 2008. Nanomechanics of collagen fibrils under varying cross-link densities: atomistic and continuum studies. J Mech Behav Biomed Mater 1:59-67.
16. Graham S, Vomund N, Phillips L. 2004. Structural changes in human type I collagen fibrils investigated by force spectroscopy. Exp Cell Res 299:335-342.
17. Eppell SJ, Smith BN, Kahn H, et al. 2006. Nano measurements with micro-devices: mechanical properties of hydrated collagen fibrils. J Royal Soc Interface 3:117-121.
18. Shen ZL, Dodge MR, Kahn H, et al. 2008. Stress-strain experiments on individual collagen fibrils. Biophys J 95:3956-3963.
19. Alini M, Eisenstein SM, Ito K, et al. 2008. Are animal models useful for studying human disc disorders/degeneration? Eur Spine J 17:2-19.
20. Bertram H, Steck E, Zimmermann G, et al. 2006. Accelerated intervertebral disc degeneration in scoliosis versus physiological ageing develops against a background of enhanced anabolic gene expression. Biochem Biophys Res Commun 342:963-972.
21. Kassner A, Hansen U, Miosge N. 2003. Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded micro fibrils. Matrix Biol 22:131-143.
22. Stolz M, Gottardi R, Raiteri R, et al. 2009. Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy. Nature Nanotechnol 4:186-192.
23. Roberts S, Menage J, Eisenstein SM. 1993. The cartilage endplate and intervertebral disc in scoliosis: calcification and other sequelae. J Orthop Res 11:747-757.
24. Keene DR, Oxford J, Morris NP. 1995. Ultrastructural localization of collagen types II, IX, and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrils. J Histochem Cytochem 43:967-979.
25. Bunger HM, Foss M, Erlacher K, et al. 2006. Nanostructure of the neurocentral growth plate: insight from scanning small angle X-ray scattering, atomic force microscopy and scanning electron microscopy. Bone 39:530-541.
26. Akhtar S, Davies JR, Caterson B. 2005. Ultrastructural localization and distribution of proteoglycan in normal and scoliotic lumbar disc. Spine 30:1303-1309.
27. Nakamura N, Hart DA, Boorman RS, et al. 2000. Decorin antisense gene therapy improves functional healing of early rabbit ligament scar with enhanced collagen fibrillogenesis in vivo. J Orthop Res 18:517-523.
28. Zhao CQ, Wang LM, Jiang LS, et al. 2007. The cell biology of intervertebral disc aging and degeneration. Ageing Res Rev 6:247-261.
29. Eyre DR. 2004. Collagens and cartilage matrix homeostasis. Clin Orthop Relat Res 427S:S118-S122.
30. Jim JJ, Noponen-Hietala N, Cheung KM, et al. 2005. The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 30:2735-2742.
31. Tang H, Buehler MJ, Moran B. 2009. A constitutive model of soft tissue: from nanoscale collagen to tissue continuum. Ann Biomed Eng 37:1117-1130.
32. Kaab MJ, Ito K, Rahn B, et al. 2000. Effect of mechanical load on articular cartilage collagen structure: a scanning electron-microscopic study. Cells Tissues Organs 167:106-120.
33. Buehler MJ, Wong SY. 2007. Entropic elasticity controls nanomechanics of single tropocollagen molecules. Biophys J 93:37-43.