Expression of the Trp2 allele of COL9A2 is associated with alterations in the mechanical properties of human intervertebral discs

Spine

Volumn 32, Issue 25, 2007, Pages 2820-2826

  Aladin, Darwesh M K ^a   Cheung, Kenneth M C ^a   Chan, Danny ^a   Yee, Anita F Y ^a   Jim, Jeffrey J T ^a   Luk, Keith D K ^a   Lu, William W ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Biomechanics; COL9A2; Collagen; Degeneration; Intervertebral disc; Nucleus pulposus; Polymorphism; Trp2

Indexed keywords

COLLAGEN TYPE 9; COL9A2 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADOLESCENT; ALLELE; ANNULUS FIBROSUS; ARTICLE; BACKACHE; BIOMECHANICS; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA EXTRACTION; DNA POLYMORPHISM; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; NUCLEUS PULPOSUS; PRIORITY JOURNAL; SCOLIOSIS; SPINE; SPINE FUSION; ADULT; CHEMISTRY; COMPARATIVE STUDY; COMPRESSIVE STRENGTH; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; LOW BACK PAIN; METABOLISM; PATHOPHYSIOLOGY; PRESSURE; RISK FACTOR; SPINE DISEASE;

ADOLESCENT; ADULT; BIOMECHANICS; COLLAGEN TYPE IX; COMPRESSIVE STRENGTH; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; LOW BACK PAIN; POLYMORPHISM, GENETIC; PRESSURE; RISK FACTORS; SCOLIOSIS; SPINAL DISEASES;

EID: 39049156861     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31815b75c5     Document Type: Article

References (16)

1. Urban JP, Roberts S. Development and degeneration of the intervertebral discs. Mol Med Today 1995;1:329.
2. Battie MC, Videman T, Parent E. Lumbar disc degeneration: epidemiology and genetic influences. Spine 2004;29:2679-90.
3. Chan D, Song Y, Sham P, et al. Genetics of disc degeneration. Eur Spine J 2006;15(suppl):317-25.
4. Cheung KM, Chan D, Karppinen J, et al. Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine 2006;31:1143-8.
5. Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine 2006;31:2151-61.
6. Annunen S, Paassilta P, Lohiniva J, et al. An allele of COL9A2 associated with intervertebral disc disease. Science 1999;285:409-12.
7. Jim JJ, Noponen-Hietala N, Cheung KM, et al. The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 2005;30:2735-42.
8. Eyre DR, Pietka T, Weis MA, et al. Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage. J Biol Chem 2004;279:2568-74.
9. Diab M, Wu JJ, Eyre DR. Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites. Biochem J 1996;314:327-32.
10. Roberts S, Menage J, Einstein SM. The cartilage end-plate and intervertebral disc in scoliosis: calcification and other sequelae. J Orthop Res 1993;11:747-57.
11. Chen CH, Yeh ML, Geyer M, et al. Interaction collagen IX and biglycan measured by atomic force microscopy. Biochem Biophys Res Commun 2006;339:204-8.
12. Perie D, Korda D, Iatridis JC. Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability. J Biomech 2004;38:2164-71.
13. Johannessen W, Elliot DM. Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine 2005; 30:E724-9.
14. Nerlich AG, Schleicher ED, Boos N. 1997 Volvo Award winner in basic science studies: immunohistologic markers for age-related changes of human lumbar intervertebral discs. Spine 1997;22:2781-95.
15. Matsui Y, Wu JJ, Weis MA, et al. Matrix deposition of tryptophancontaining allelic variants of type IX collagen in developing human cartilage. Matrix Biol 2003;22:123-9.
16. Aladin DK, Lu WW, Cheung KMC, et al. Best paper award winner: nano biomechanics of type II collagens in human intervertebral discs. Biomedical Engineering Conference, Hong Kong, China, 2006:21-3.