Particulate depleted uranium is cytotoxic and clastogenic to human lung epithelial cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 697, Issue 1-2, 2010, Pages 33-37

  LaCerte, Carolyne ^a   Xie, Hong ^a   Aboueissa, AbouEl Makarim ^a   Wise Sr , John Pierce ^a  

^a UNIVERSITY OF SOUTHERN MAINE   (United States)

Author keywords

Cytotoxicity; Depleted uranium; Genotoxicity; Lung cells

Indexed keywords

CARCINOGEN; CLASTOGEN; DEPLETED URANIUM; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CHROMOSOME ABERRATION; CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

BRONCHI; CARCINOGENS; CELL DEATH; CELL LINE; EPITHELIAL CELLS; HUMANS; LUNG; MUTAGENS; PARTICULATE MATTER; URANIUM; URANIUM COMPOUNDS;

EID: 77949492009     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.01.013     Document Type: Article

References (38)

1. The Royal Society, The Health Effects of Depleted Uranium Munitions: Summary. Document 6/02, London, UK, 2002.
2. Bleise A., Danesi P.R., and Burkart W. Properties, use and health effects of depleted uranium (DU): a general overview. J. Environ. Radioact. 64 (2003) 93-112
3. World Health Organization, Health Effects of Depleted Uranium. Report by the Secretariat. Document A54/19 Add.1, WHO, Geneva, Switzerland, 2001.
4. Committee on Gulf War and Health: Updated Literature Review of Depleted Uranium (2008), Institute of Medicine, The National Academies Press, Washington, DC
5. Domingo J.L. Reproductive and developmental toxicity of natural and depleted uranium: a review. Reprod. Toxicol. 15 (2001) 603-609
6. Bosque M.A., Domingo J.L., Llobet J.M., and Corbella J. Embryotoxicity and teratogenicity of uranium in mice following subcutaneous administration of uranyl acetate. Biol. Trace Elem. Res. 36 (1992) 109-118
7. Mould R.F. Depleted uranium and radiation-induced lung cancer and leukaemia. Br. J. Radiol. 74 (2001) 677-683
8. Lagorio S., Grande E., and Martina L. Review of epidemiological studies of cancer risk among Gulf War and Balkans veterans. Epidemiol. Prev. 32 (2008) 145-155
9. Institute of Medicine. Gulf War and Health: Updated Literature Review of Depleted Uranium (2008), The National Academies Press, Washington, DC
10. McClain D.R., Benson K.A., Dalton T.K., Ejnik J., Emond C.A., Hodge S.J., Kalinich J.F., Landauer M.R., Livengood D.R., and Miller A.C. Health effects of embedded depleted uranium. Milit. Med. 167 (2003) 117-119
11. Miller A.C., Fuciarelli A.F., Jackson W.E., Ejnik E.J., Edmond C., Stocko S., Hogan J., Page N., and Pellmar T. Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets. Mutagenesis 13 (1998) 643-648
12. Hahn F.F., Guilmette R.A., and Hoover M.D. Implanted depleted uranium fragments cause soft tissue sarcomas in the muscles of rats. Environ. Health Perspect. 110 (2002) 51-59
13. Monleau M., DeMeo M., Paquet F., Chazel V., Dumenil G., and Donnadieu-Claraz M. Genotoxic and inflammatory effects of depleted uranium particles inhaled by rats. Toxicol. Sci. 89 (2006) 287-295
14. Xie H., LaCerte C., Thompson D., and Wise J.P. Depleted uranium induces neoplastic transformation in human lung epithelial cells. Chem. Res. Toxicol. 23 (2010) 373-378
15. Miller A.C., Blakely W.F., Livengood D., Whittaker T., Xu J., Ejnik J.W., Hamilton M.M., Parlett E., St. John T., Gerstenberg H.M., and Hsu H. Depleted uranium-uranyl transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium chloride. Environ. Health Perspect. 106 (1998) 465-471
16. Miller A.C., Xu J., Stewart M., Prasanna P.G., and Page N. Potential late health effects of depleted uranium and tungsten used in armor-piercing munitions: comparison of neoplastic transformation and genotoxicity with the known carcinogen nickel. Milit. Med. 167 (2002) 120-122
17. Miller A.C., Blakely W.F., Livengood D., Whittaker T., Xu J., Ejnik J.W., Hamilton M.M., Parlette E., St. John T., Gerstenberg H.M., and Hsu H. Transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium-uranyl chloride. Environ. Health Perspect. 106 (1998) 465-471
18. Yang Z.H., Fan B.X., Lu Y., Cao Z.S., Yu S., Fan F.Y., and Zhu M.X. Malignant transformation of human bronchial epithelial cells (BEAS-2B) induced by depleted uranium. Aizheng 21 (2002) 944-948
19. Miller A.C., Brooks K., Stewart M., Anderson B., Lin S., McClain D., and Page N. Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation. J. Environ. Radioact. 64 (2003) 247-259
20. Wise S.S., Thompson W.D., Aboueissa A., Mason M.D., and Wise Sr. J.P. Particulate depleted uranium is cytotoxic and clastogenic to human lung cells. Chem. Res. Toxicol. 20 (2007) 815-820
21. Yazzie M., Gamble S.L., Civitello E.R., and Stearns D.M. Uranyl acetate causes DNA single strand breaks in vitro in the presence of ascorbate (Vitamin C). Chem. Res. Toxicol. 16 (2003) 524-530
22. Bem H., and Bou-Rabee F. Environmental and health consequences of depleted uranium use in the 1991 Gulf War. Environ. Intern. 30 (2004) 123-134
23. Kurose K., Hoshaw-Woodard S., Adeyinka A., Lemeshow S.H., Watson P., and Eng C. Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. Hum. Mol. Genet. 10 (2001) 1907-1913
24. Rubin H. Selected cell and selective microenvironment in neoplastic development. Cancer Res. 61 (2001) 799-807
25. Willey J.C., Broussoud A., Sleemi A., Bennett W.P., Cerutti P., and Harris C.C. Immortalization of normal human bronchial epithelial cells by human papillomaviruses 16 or 18. Cancer Res. 51 (1991) 5370-5377
26. Hei T.K., Piao C.Q., Willey J.C., Thomas S., and Hall E.J. Malignant transformation of human bronchial epithelial cells by radon-simulated alpha-particles. Carcinogenesis 15 (1994) 431-437
27. Hei T.K., Wu L.J., and Piao C.Q. Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers. Environ. Health Perspect. 105 (1997) 1085-1088
28. Zhao Y.L., Piao C.Q., Hall E.J., and Hei T.K. Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. Radiat. Res. 155 (2001) 230-234
29. Xie H., Holmes A.L., Wise S.S., Huang S., Peng C., and Wise Sr. J.P. Neoplastic transformation of human bronchial cells by lead chromate particles. Am. J. Respir. Cell Mol. Biol. 37 (2007) 544-552
30. Hei T.K., Piao C.Q., Han E., Sutter T., and Willey J.C. Radon induced neoplastic transformation of human bronchial epithelial cells. Rad. Oncol. Invest. 3 (1996) 398-403
31. Wise S.S., Holmes A.L., and Wise Sr. J.P. Particulate and soluble hexavalent chromium are cytotoxic and genotoxic to human lung epithelial cells. Mutat. Res. 610 (2006) 2-7
32. Xie H., Wise S.S., Holmes A.L., Xu B., Wakeman T.P., Pelsue S.C., Singh N.P., and Wise Sr. J.P. Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells. Mutat. Res. 586 (2005) 160-172
33. Mietz J.A., Unger T., Huibregtse J.M., and Howley P.M. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO 11 (1992) 5013-5020
34. Zuckerman V., Wolyniec K., Sionov R.V., Haupt S., and Haupt T. Tumour suppression by p53: the importance of apoptosis and cellular senescence. J. Pathol. 219 (2009) 3-15
35. Stearns D.M., Yazzie M., Bradley A.S., Asplund C.A., and Lantz R.C. Uranyl acetate induces HPRT mutations and uranium-DNA adducts in Chinese hamster ovary EM9 cells. Mutagenesis 20 (2006) 417-423
36. McDiarmid M.A., Engelhardt S.M., Dorsey C.D., Oliver M., Gucer P., Wilson P.D., Kane R., Cernich A., Kaup B., Anderson L., Hoover D., Brown L., Albertini R., Gudi R., and Squibb K.S. Surveillance results of depleted uranium-exposed Gulf War I veterans: sixteen years of follow-up. J. Toxicol. Environ. Health 72 (2009) 14-29
37. Zelikoff J.T., Li J.H., Hartwig A., Wang X.W., Costa M., and Rossman T.G. Genetic toxicology of lead compounds. Carcinogenesis 9 (1988) 1727-1732
38. Lin R.H., Wu L.J., Lee C.H., and Lin-Shiau S.Y. Cytogenetic toxicity of uranyl nitrate in Chinese hamster ovary cells. Mutat. Res. 319 (1993) 197-203