Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors

Autonomic Neuroscience: Basic and Clinical

Volumn 154, Issue 1-2, 2010, Pages 14-19

  Li, Yi Fan ^a   LaCroix, Carly ^a   Freeling, Jessica ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Cytisine; Ganglia; Heart rate; Nicotinic receptors; Parasympathetic; Sympathetic

Indexed keywords

ATROPINE; CYTISINE; DIHYDRO BETA ERYTHROIDINE; H 0879; HEXAMETHONIUM; METHYLLYCACONITINE CITRATE; MLA 1029; N 5260; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PRAZOSIN; UNCLASSIFIED DRUG; URETHAN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRADYCARDIA; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG RESPONSE; DRUG SELECTIVITY; HEART INNERVATION; HEART RATE; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRESSOR RESPONSE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL;

ACONITINE; ADRENERGIC ALPHA-ANTAGONISTS; ALKALOIDS; ANALYSIS OF VARIANCE; ANIMALS; ATROPINE; AZOCINES; BLOOD PRESSURE; BRADYCARDIA; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; DIHYDRO-BETA-ERYTHROIDINE; HEART RATE; HEXAMETHONIUM; MALE; MICE; MUSCARINIC ANTAGONISTS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PRAZOSIN; QUINOLIZINES; RECEPTORS, NICOTINIC;

EID: 77949491359     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2009.09.023     Document Type: Article

References (22)

1. Albuquerque E.X., Pereira E.F., Alkondon M., and Rogers S.W. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol. Rev. 89 (2009) 73-120
2. Alexander S.P., Mathie A., and Peters J.A. Guide to receptors and channels (GRAC), 3rd edition. Br. J. Pharmacol. 153 Suppl 2 (2008) S1-S209
3. Behling A., Moraes R.S., Rohde L.E., Ferlin E.L., Nobrega A.C., and Ribeiro J.P. Cholinergic stimulation with pyridostigmine reduces ventricular arrhythmia and enhances heart rate variability in heart failure. Am. Heart J. 146 (2003) 494-500
4. Bibevski S., and Dunlap M.E. Ganglionic mechanisms contribute to diminished vagal control in heart failure. Circulation 99 (1999) 2958-2963
5. De Biasi M. Nicotinic mechanisms in the autonomic control of organ systems. J. Neurobiol. 53 (2002) 568-579
6. Deck J., Bibevski S., Gnecchi-Ruscone T., Bellina V., Montano N., and Dunlap M.E. Alpha7-nicotinic acetylcholine receptor subunit is not required for parasympathetic control of the heart in the mouse. Physiol. Genomics. 22 (2005) 86-92
7. Donnelly-Roberts D.L., Puttfarcken P.S., Kuntzweiler T.A., Briggs C.A., Anderson D.J., Campbell J.E., et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. J. Pharmacol. Exp. Ther. 285 (1998) 777-786
8. Felix B., Catalin D., Miolan J.P., and Niel J.P. Integrative properties of the major pelvic ganglion in the rat. J Auton Nerv Syst. 69 (1998) 6-11
9. Franceschini D., Orr-Urtreger A., Yu W., Mackey L.Y., Bond R.A., Armstrong D., et al. Altered baroreflex responses in alpha7 deficient mice. Behav. Brain Res. 113 (2000) 3-10
10. Freeling J., Wattier K., Lacroix C., and Li Y.F. Neostigmine and pilocarpine attenuated TNF{alpha} expression and cardiac hypertrophy in the heart with pressure overload. Exp Physiol (2007)
11. Frontoni S., Bracaglia D., and Gigli F. Relationship between autonomic dysfunction, insulin resistance and hypertension, in diabetes. Nutr. Metab. Cardiovasc. Dis. 15 (2005) 441-449
12. Ji S., Tosaka T., Whitfield B.H., Katchman A.N., Kandil A., Knollmann B.C., et al. Differential rate responses to nicotine in rat heart: evidence for two classes of nicotinic receptors. J. Pharmacol. Exp. Ther. 301 (2002) 893-899
13. Julius S. Autonomic nervous system dysregulation in human hypertension. Am. J. Cardiol. 67 (1991) 3B-7B
14. Li M., Zheng C., Sato T., Kawada T., Sugimachi M., and Sunagawa K. Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 109 (2004) 120-124
15. Lindmark S., Wiklund U., Bjerle P., and Eriksson J.W. Does the autonomic nervous system play a role in the development of insulin resistance? A study on heart rate variability in first-degree relatives of Type 2 diabetes patients and control subjects. Diabet. Med. 20 (2003) 399-405
16. Listerud M., Brussaard A.B., Devay P., Colman D.R., and Role L.W. Functional contribution of neuronal AChR subunits revealed by antisense oligonucleotides. Science 254 (1991) 1518-1521
17. Mandelzys A., Pie B., Deneris E.S., and Cooper E. The developmental increase in ACh current densities on rat sympathetic neurons correlates with changes in nicotinic ACh receptor alpha-subunit gene expression and occurs independent of innervation. J. Neurosci. 14 (1994) 2357-2364
18. Olshansky B., Sabbah H.N., Hauptman P.J., and Colucci W.S. Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy. Circulation 118 (2008) 863-871
19. Porter T.R., Eckberg D.L., Fritsch J.M., Rea R.F., Beightol L.A., Schmedtje Jr. J.F., et al. Autonomic pathophysiology in heart failure patients. Sympathetic-cholinergic interrelations. J. Clin. Invest. 85 (1990) 1362-1371
20. Rust G., Burgunder J.M., Lauterburg T.E., and Cachelin A.B. Expression of neuronal nicotinic acetylcholine receptor subunit genes in the rat autonomic nervous system. Eur. J. Neurosci. 6 (1994) 478-485
21. Skok V.I. Nicotinic acetylcholine receptors in autonomic ganglia. Auton. Neurosci. 97 (2002) 1-11
22. Zhang J., and Steinbach J.H. Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates. Brain Res. 959 (2003) 98-102