Synthesis and biological activity of n-butylphthalide derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1941-1946

  Wang, Wei ^a   Cha, Xue Xiang ^b   Reiner, John ^a   Gao, Yuan ^b   Qiao, Hai Ling ^b   Shen, Jia Xiang ^a   Chang, Jun Biao ^a,b  

^a TIANJIN UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

n Butylphalide; Synthesis; Vasorelaxant effects

Indexed keywords

3 BUTYL 6 BROMO 1 (3H)ISOBENZOFURANONE; 3 BUTYL 6 FLUORO 1 (3H)ISOBENZOFURANONE; FURANONE DERIVATIVE; NORADRENALIN; PHTHALIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; MELTING POINT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; THORACIC AORTA; TOXICITY TESTING; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; BENZOFURANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MICE; MOLECULAR STRUCTURE; RATS; STEREOISOMERISM; VASODILATOR AGENTS;

EID: 77949484634     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.036     Document Type: Article

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