Mitochondrial Function: OMA1 and OPA1, the Grandmasters of Mitochondrial Health

Current Biology

Volumn 20, Issue 6, 2010, Pages

  McBride, Heidi ^a   Soubannier, Vincent ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; METALLOPROTEINASE; MITOCHONDRIAL PROTEIN;

ANIMAL; BIOLOGICAL MODEL; HUMAN; MEMBRANE FUSION; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PHYSIOLOGY; SHORT SURVEY;

ANIMALS; GTP PHOSPHOHYDROLASES; HUMANS; MEMBRANE FUSION; METALLOENDOPEPTIDASES; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL;

EID: 77949479537     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2010.02.011     Document Type: Short Survey

References (18)

1. Mouli P.K., Twig G., and Shirihai O.S. Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys. J. 96 (2009) 3509-3518
2. Duvezin-Caubet S., Jagasia R., Wagener J., Hofmann S., Trifunovic A., Hansson A., Chomyn A., Bauer M.F., Attardi G., Larsson N.G., et al. Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J. Biol. Chem. 281 (2006) 37972-37979
3. Griparic L., Kanazawa T., and van der Bliek A.M. Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage. J. Cell Biol. 178 (2007) 757-764
4. Song Z., Chen H., Fiket M., Alexander C., and Chan D.C. OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. J. Cell Biol. 178 (2007) 749-755
5. Head B., Griparic L., Amiri M., Gandre-Babbe S., and van der Bliek A.M. Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J. Cell Biol. 187 (2009) 959-966
6. Ehses S., Raschke I., Mancuso G., Bernacchia A., Geimer S., Tondera D., Martinou J.C., Westermann B., Rugarli E.I., and Langer T. Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J. Cell Biol. 187 (2009) 1023-1036
7. Delettre C., Griffoin J.M., Kaplan J., Dollfus H., Lorenz B., Faivre L., Lenaers G., Belenguer P., and Hamel C.P. Mutation spectrum and splicing variants in the OPA1 gene. Hum. Genet. 109 (2001) 584-591
8. Soubannier V., and McBride H.M. Positioning mitochondrial plasticity within cellular signaling cascades. Biochim. Biophys. Acta 1793 (2009) 154-170
9. Kaser M., Kambacheld M., Kisters-Woike B., and Langer T. Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease. J. Biol. Chem. 278 (2003) 46414-46423
10. Bao Y.C., Tsuruga H., Hirai M., Yasuda K., Yokoi N., Kitamura T., and Kumagai H. Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif. DNA Res. 10 (2003) 123-128
11. Geissler A., Krimmer T., Bomer U., Guiard B., Rassow J., and Pfanner N. Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence. Mol. Biol. Cell 11 (2000) 3977-3991
12. Duvezin-Caubet S., Koppen M., Wagener J., Zick M., Israel L., Bernacchia A., Jagasia R., Rugarli E.I., Imhof A., Neupert W., et al. OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Mol. Biol. Cell 18 (2007) 3582-3590
13. Tatsuta T., and Langer T. AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines. Res. Microbiol. 160 (2009) 711-717
14. Osman C., Merkwirth C., and Langer T. Prohibitins and the functional compartmentalization of mitochondrial membranes. J. Cell Sci. 122 (2009) 3823-3830
15. Osman C., Haag M., Potting C., Rodenfels J., Dip P.V., Wieland F.T., Brugger B., Westermann B., and Langer T. The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Biol. 184 (2009) 583-596
16. Sakoh M., Ito K., and Akiyama Y. Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli. J. Biol. Chem. 280 (2005) 33305-33310
17. Herlan M., Bornhovd C., Hell K., Neupert W., and Reichert A.S. Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J. Cell Biol. 165 (2004) 167-173
18. McQuibban G.A., Lee J.R., Zheng L., Juusola M., and Freeman M. Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Curr. Biol. 16 (2006) 982-989