Pathophysiology of right ventricular failure in pulmonary hypertension

Pediatric Critical Care Medicine

Volumn 11, Issue SUPPL. 2, 2010, Pages

  Bronicki, Ronald A ^a,b   Baden, Harris P ^c  

^a CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiopulmonary interaction; Heart failure; Pulmonary hypertension; Right ventricle; Ventricular interdependence

Indexed keywords

CONFERENCE PAPER; CONGENITAL HEART DISEASE; CRITICALLY ILL PATIENT; FUNCTIONAL ANATOMY; HEART AFTERLOAD; HEART FUNCTION; HEART RIGHT VENTRICLE FAILURE; HEART VENTRICLE; HUMAN; LUNG VEIN HYPERTENSION; PATHOPHYSIOLOGY; PATIENT CARE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY TRACT DISEASE; TOTAL ANOMALOUS PULMONARY VENOUS RETURN; VENTRICULAR INTERDEPENDENCE;

EID: 77949462588     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181c7671c     Document Type: Conference Paper

References (83)

1. Dell'Italia LJ: The right ventricle: Anatomy, physiology, and clinical importance. Curr Probl Cardiol 1991; 16:653-720
2. Haddad F, Hunt SA, Rosenthal DN, et al: Right ventricular function in cardiovascular disease, Part I. Anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation 2008; 117:1436-1448
3. James TN: Anatomy of the crista supraventricularis: Its importance for understanding right ventricular function, right ventricular infarction and related conditions. J Am Coll Cardiol 1985; 6:1083-1095
4. Sallin EA: Fiber orientation and ejection fraction in the human ventricle. Biophys J 1969; 9:954-964
5. Castella M, Buckberg GD, Saleh S, et al: Structure function interface with sequential shortening of basal and apical components of the myocardial band. Eur J Cardiothorac Surg 2005; 27:980-987
6. Anderson RH, Sanchez-Quintana D, Niederer P, et al: Structural-functional correlates of the 3-dimensional arrangement of the myocytes making up the ventricular walls. J Thorac Cardiovasc Surg 2008; 136:10-18
7. Buckberg G: Cardiac structure/function relationships: Reality or deduction? J Thorac Cardiovasc Surg 2008; 136:19-20
8. Saleh S, Liakopoulos OJ, Buckberg GD: The septal motor of biventricular function. Eur J Cardiothorac Surg 2006; 29S:S126-S138
9. Santamore WP, Lynch PR, Meier G, et al: Myocardial interaction between the ventricles. J Appl Physiol 1976; 41:362-368
10. Lima JAC, Guzman PA, Yin FCP, et al: Septal geometry in the unloaded living human heart. Circulation 1986; 74:463-468
11. Peters J, Kindred MK, Robotham JL: Transient analysis of cardiopulmonary interactions. I. Diastolic events. J Appl Physiol 1988; 64:1506-1517
12. Weyman AE, Wann S, Feigenbaum H, et al: Mechanism of abnormal septal motion in patients with right ventricular volume overload. Circulation 1976; 54:179-186
13. Marcus JT, Gan CTJ, Zwanenburg J, et al: Interventricular mechanical asynchrony in pulmonary arterial hypertension. J Am Coll Cardiol 2008; 51:750-757
14. Takagaki M, Ishino K, Kawada M, et al: Total right ventricular exclusion improves left ventricular function in patients with end-stage congestive right ventricular failure. Circulation 2003; 108(Suppl II):II-226-II229
15. Santamore WP, Dell'Italia LJ: Ventricular interdependence: Significant left ventricular contributions to right ventricular systolic function. Prog Cardiovasc Dis 1998; 40: 289-308
16. Damiano RJ Jr, La Follette P Jr, Cox JL, et al: Significant left ventricular contribution to right ventricular systolic function. Am J Physiol 1991; 261:H1514-H1524
17. Feneley MP, Gavaghan TP, Baron DW, et al: Contribution of left ventricular contraction to the generation of right ventricular systolic pressure in the human heart. Circulation 1985; 71:473-481
18. Santamore WP, Lynch PR, Heckman JL, et al: Left ventricular effects on right ventricular developed pressure. J Appl Physiol 1976; 41:925-930
19. Janicki JS, Weber KT: The pericardium and ventricular interaction, distensibility, and function. Am J Physiol 1980; 238: H494-H503
20. Maruyama Y, Ashikawa K, Isoyama S, et al: Mechanical interactions between four heart chambers with and without the pericardium in canine hearts. Circ Res 1982; 50:86-100
21. Goldstein JA, Vlahakes GJ, Verrier ED, et al: The role of right ventricular systolic dysfunction and elevated intrapericardial pressure in the genesis of low output in experimental right ventricular infarction. Circulation 1982; 65:513-522
22. Page RD, Harringer W, Hodakowski GT, et al: Determinants of maximal right ventricular function. J Heart Lung Transplant 1992; 11: 90-98
23. Hon JKF, Steendijk P, Khan H, et al: Acute effects of pulmonary artery banding in sheep on right ventricle pressure-volume relations: Relevance to the arterial switch operation. Acta Physiol Scand 2001; 172:97-106
24. Vroomen MJD, Lopes Cardozo RH, Steendijk P, et al: Improved contractile performance of right ventricle in response to increased RV afterload in newborn lamb. Am J Physiol 2000; 278:H100-H105
25. Nootens M, Kaufmann E, Rector T, et al: Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels. J Am Coll Cardiol 1995; 26:1581-1585
26. Wang GY, McCloskey DT, Turcato S, et al: Contrasting inotropic responses to adrenergic receptor stimulation in left versus right ventricular myocardium. Am J Physiol Heart Circ Physiol 2006; 291:H2013-H2017
27. Dias CA, Assad RS, Caneo LF, et al: Reversible pulmonary trunk banding. II. An experimental model for rapid pulmonary ventricular hypertrophy. J Thorac Cardiovasc Surg 21002;124:999-1006
28. Anversa P, Olivetti G, Loud AV: Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. I. Hypertrophy, hyperplasia, and binucleation of myocytes. Circ Res 1980; 46: 495-502
29. Hopkins WE, Waggoner AD: Severe pulmonary hypertension without right ventricular failure: The unique hearts of patients with Eisenmenger syndrome. Am J Cardiol 2002; 89:34-38
30. Hopkins WE: The remarkable right ventricle of patients with Eisenmenger syndrome. Coron Artery Dis 2005; 16:19-25
31. Chin KM, Kim NH, Rubin LJ: The right ventricle in pulmonary hypertension. Coron Artery Dis 2005; 16:13-18
32. Saha A, Balakrishnan KG, Jaiswal PK, et al: Prognosis for patients with Eisenmenger syndrome of various aetiology. Int J Cardiol 1994; 45:199-207
33. Bristow MR, Zisman LS, Lowes BD, et al: The pressure-overloaded right ventricle in pulmonary hypertension. Chest 1998; 114: 101S-106S
34. Lowes BD, Minobe W, Abraham WT, et al: Changes in gene expression in the intact human heart: Downregulation of alphamyosin heavy chain in hypertrophied, failing ventricular myocardium. J Clin Invest 1997; 100:2315-2324
35. Goldstein JA, Harada A, Yagi Y, et al: Hemodynamic importance of systolic ventricular interaction augmented right atrial contractility and atrioventricular synchrony in acute right ventricular dysfunction. J Am Coll Cardiol 1990; 16:181-189
36. Gan C, Holverda S, Marcus T, et al: Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients. Chest 2007; 132:11-17
37. Chen EP, Craig DM, Bittner HB, et al: Pharmacological strategies for improving diastolic dysfunction in the setting of chronic pulmonary hypertension. Circulation 1998; 97:1606-1612
38. Gan TJ, Lankhaar JW, Marcus JT, et al: Impaired left ventricular filling due to right-toleft ventricular interaction in patients with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol 2006; 290: H1528-H1533
39. Belenkie I, Horne GS, Dani R, et al: Effects of aortic constriction during experimental acute right ventricular pressure loading. Circulation 1995; 92:546-554
40. Yamashita H, Onodera S, Imamoto T, et al: Functional and geometrical interference and interdependency between the right and left ventricle in cor pulmonale: An experimental study on simultaneous measurement of biventricular geometry of acute right ventricular pressure overload. Jpn Circ J 1989; 53:1237-1244
41. Dell'Italia LJ, Starling MR, Blumhardt R, et al: Comparative effects of volume loading, dobutamine, and nitroprusside in patients with predominant right ventricular infarction. Circulation 1985; 72:1327-1335
42. Ghignone M, Girling L, Prewitt RM: Volume expansion versus norepinephrine in treatment of a low cardiac output complicating an acute increase in right ventricular afterload in dogs. Anesthesiology 1984; 60:132-135
43. Packer M, Greenberg B, Massie B, et al: Deleterious effects of hydralazine in patients with pulmonary hypertension. N Engl J Med 1982; 306:1326-1331
44. Parker M, Medina N, Yushak M: Adverse hemodynamic and clinical effects of calcium channel blockade in pulmonary hypertension secondary to obliterative pulmonary vascular disease. J Am Coll Cardiol 1984; 4:890-901
45. Weir EK, Rubin LJ, Ayres SM, et al: The acute administration of vasodilators in primary pulmonary hypertension. Am Rev Respir Dis 1989; 140:1623-1630
46. Ricciardi MJ, Bossone E, Bach DS, et al: Echocardiographic predictors of an adverse response to a nifedipine trial in primary pulmonary hypertension: Diminished left ventricular size and leftward ventricular septal bowing. Chest 1999; 116:1218-1223
47. Simonneau G, Galie N, Rubin LJ, et al: Clinical classification of pulmonary hypertension. J Am Coll Cardiol 2004; 43:5S-12S
48. Zakir RM, Al-Dehneh A, Maher J, et al. Right ventricular failure in patients with preserved ejection fraction and diastolic dysfunction: An underrecognized clinical entity. Congest Heart Fail 2007; 13:164-169
49. Ben Driss A, Devaux C, Henrion D, et al: Hemodynamic stresses induce endothelial dysfunction and remodeling of pulmonary artery in experimental compensated heart failure. Circulation 2000; 101:2764-2770
50. Cody R, Haas GJ, Binkley PF, et al: Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation 1992; 85:504-509
51. Juilliere Y, Barbier G, Feldmann L, et al: Additional predictive value of both left and right ventricular ejection fractions on longterm survival in idiopathic dilated cardiomyopathy. Eur Heart J 1997; 18:276-280
52. Spinarova L, Meluzin J, Toman J, et al: Right ventricular dysfunction in chronic heart failure patients. Eur J Heart Fail 2005; 7:485-489
53. Kingsbury MP, Huang W, Donnelly JL, et al: Structural remodeling of lungs in chronic heart failure. Basic Res Cardiol 2003; 98: 295-303
54. Kay JM, Edwards FR: Ultrastructure of the alveolar-capillary wall in mitral stenosis. J Pathol 1973; 111:239-245
55. Bachofen H, Schurch S, Weibel ER: Experimental hydrostatic pulmonary edema in rabbit lungs. Am Rev Respir Dis 1993; 147: 997-1004
56. Tsukimoto K, Mathieu-Costello O, Prediletto R, et al: Ultrastructural appearances of pulmonary capillaries at high transmural pressures. J Appl Physiol 1991; 71:573-582
57. Semigran MJ, Cockrill AB, Kacmarek R, et al: Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol 1994; 24:982-988
58. Loh E, Stamler JS, Hare JM, et al: Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation 1994; 90:2780-2785
59. Lepore JJ, Maroo A, Bigatello LM, et al: Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension. Chest 2005; 127:1647-1653
60. Lewis GD, Lachmann J, Camuso J, et al: Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation 2007; 115:59-66
61. Argenziano M, Choudhri AF, Moazami N, et al: Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension. Ann Thorac Surg 1998; 65:340-345
62. Behrendt DM, Aberdeen E, Waterson DJ, et al: Total anomalous pulmonary venous drainage in infants. I. Clinical and hemodynamic findings, methods, and results of operation in 37 cases. Circulation 1972; 46: 347-356
63. Phoon CKL, Silverman NH: Conditions with right ventricular pressure and volume overload, and a small left ventricle: " Hypoplastic" left ventricle or simply a squashed ventricle? J Am Coll Cardiol 1997; 30:1547-1553
64. Atz AM, Wessel DL: Inhaled nitric oxide in the neonate with cardiac disease. Semin Perinatol 1997; 21:441-455
65. Atz AM, Adatia I, Jonas RA, et al: Inhaled nitric oxide in children with pulmonary hypertension and congenital mitral stenosis. Am J Cardiol 1996; 77:316-319
66. Mahoney PD, Loh E, Blitz LR, et al: Hemodynamic effects of inhaled nitric oxide in women with mitral stenosis and pulmonary hypertension. Am J Cardiol 2001; 87: 188-192
67. Hess W, Arnold B, Veit S: The haemodynamic effects of amrinone in patients with mitral stenosis and pulmonary hypertension. Eur Heart J 1986; 7:800-807
68. Putensen C, Rasanen J, Downs JB: Effect of endogenous and inhaled nitric oxide on the ventilation-perfusion relationships in oleicacid lung injury. Am J Respir Crit Care Med 1994; 150:330-336
69. Benzing A, Mols G, Beyer U, et al: Large increase in cardiac output in a patient with ARDS and acute right heart failure during inhalation of nitric oxide. Acta Anaesthesiol Scand 1997; 41:643-646
70. Bhorade S, Christenson J, O'Conner M, et al: Response to inhaled nitric oxide in patients with acute right heart syndrome. Am J Respir Crit Care Med 1999; 159:571-579
71. Jardin F, Brun-Ney D, Hardy A, et al: Combined thermodilution and two-dimensional echocardiographic evaluation of right ventricular function during respiratory support with PEEP. Chest 1991; 99:162-168
72. Jardin F, Farcot JC, Boisante L, et al: Influencevof positive end-expiratory pressure on left ventricular performance. N Engl J Med 1981; 304:387-392
73. Jardin F: Peep, tricuspid regurgitation, and cardiac output. Intensive Care Med 1997; 23: 806-807
74. Hoffman JIE, Rudolph AM, Heymann MA: Pulmonary vascular disease with congenital heart lesions: Pathologic features and causes. Circulation 1981; 64:873-877
75. Rabinovitch M: Pathobiology of pulmonaryv hypertension: Impact on clinical management. Semin Thorac Cardiovasc Surg 2000; 3:63-81
76. Celermajer DS, Cullen S, Deanfield JE: Impairment of endothelium- dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation 1993; 87:440-446
77. Vincent JA, Ross RD, Kassab J, et al: Relation of elevated plasma endothelin in congenital heart disease to increased pulmonary blood flow. Am J Cardiol 1993; 71:1204-1207
78. Robinson BW, Gelband H, Mas M: Selective pulmonary and systemic vasodilator effects of amrinone in children: New therapeutic implications. J Am Coll Cardiol 1993; 21: 1461-1465
79. Serraf A, Sellak H, Herve P, et al: Vascular endothelium viability and function after total cardiopulmonary bypass in neonatal piglets. Am J Respir Crit Care Med 1999; 159: 544-551
80. Wessel DL, Adatia I, Giglia TM, et al: Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Circulation 1993; 88:2128-2138
81. Schulze-Neick I, Penny DJ, Rigby ML, et al: L-Arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery. Circulation 1999; 100:749-755
82. Beghetti M, Habre W, Berner M: Continuous low dose inhaled nitric oxide for treatment of severe pulmonary hypertension after cardiac surgery in paediatric patients. Br Heart J 1995; 73:65-68
83. Miller OI, Celermajer DS, Deanfield JE, et al: Very-low-dose inhaled nitric oxide: A selective pulmonary vasodilator after operations for congenital heart disease. J Thorac Cardiovasc Surg 1994; 108:487-494