The effects of pomegranate seed extract and β-Sitosterol on Rat Uterine Contractions

Reproductive Sciences

Volumn 17, Issue 3, 2010, Pages 288-296

  Promprom, Wilawan ^a   Kupittayanant, Pakanit ^a   Indrapichate, Korakod ^a   Wray, Susan ^b   Kupittayanant, Sajeera ^a  

^a SURANAREE UNIVERSITY OF TECHNOLOGY   (Thailand)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Calcium; Pomegranate; Potassium channel; Punica granatum L; Punicaceae; Sarcoplasmic reticulum calcium ATPase; Smooth muscle; SR

Indexed keywords

CALCIUM CHANNEL L TYPE; CYCLOPIAZONIC ACID; ESTROGEN RECEPTOR; FULVESTRANT; METHANOL; MYOSIN LIGHT CHAIN KINASE; NIFEDIPINE; POMEGRANATE EXTRACT; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SITOSTEROL;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FREQUENCY MODULATION; GAS CHROMATOGRAPHY; INTRAUTERINE PRESSURE; MASS SPECTROMETRY; MUSCLE ISOMETRIC CONTRACTION; MYOMETRIUM; NONHUMAN; PRIORITY JOURNAL; RAT; UTERUS CONTRACTILITY; UTERUS CONTRACTION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MYOSIN-LIGHT-CHAIN KINASE; PLANT EXTRACTS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PUNICACEAE; RATS; RATS, WISTAR; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SEEDS; SITOSTEROLS; UTERINE CONTRACTION;

EID: 77949460855     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719109352687     Document Type: Article

References (30)

1. Langley P. Why a pomegranate ? BMJ. 2000 ; 321 (7269). 1153-1154.
2. Gil MI, Tomás-Barberán FA, Hess-Pierce B., Holcroft DM, Kader AA Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000 ; 48 (10). 4581-4589.
3. Schubert SY, Lansky EP, Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol. 1999 ; 66 (1). 11-17.
4. van Elswijk DA, Schobel UP, Lansky EP, Irth H., van der Greef J. Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry. Phytochemistry. 2004 ; 65 (2). 233-241.
5. Kim ND, Mehta B., Yu W., et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat. 2002 ; 71 (3). 203-217.
6. Jurenka JS Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008 ; 13 (2). 128-144.
7. Moneam NM, el Sharaky AS, Badreldin MM Oestrogen content of pomegranate seeds. J Chromatogr. 1988 ; 438 (2). 438-442.
8. Sharaf A., Nigm SA The oestrogenic activity of pomegranate seed oil. J Endocrinol. 1964 ; 29: 91-92.
9. Wray S., Kupittayanant S., Shmigol A., Smith RD, Burdyga TV The physiological basis of uterine contractility: a short review. Exp Physiol. 2001 ; 86 (2). 239-246.
10. Bao L., Li Y., Deng SX, Landry D., Tabas I. Sitosterolcontaining lipoproteins trigger free sterol-induced caspaseindependent death in ACAT-competent macrophages. J Bio Chem. 2006 ; 281 (44). 33635-33649.
11. Shmygol A., Noble K., Wray S. Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytes. J Physiol Lond. 2007 ; 581 (pt 2). 445-456.
12. Promprom W., Kupittayanant S., Indrapichate K., Kupittayanant P. Effects of pomegranate extracts on rat uterine contraction. Planta Med. 2007 ; 73: 1007.
13. Longbottom ER, Luckas MJM, Kupittayanant S., Badrick E., Shmigol A., Wray S. The effects of inhibiting myosin light chain kinase on contraction and calcium signalling in human and rat myometrium. Pflugers Arch. 2000 ; 440 (2). 315-321.
14. Shmigol A., Eisner DA, Wray S. Properties of voltage-activated [Ca2+]i transients in single smooth muscle cells isolated from pregnant rat uterus. J Physiol Lond. 1998 ; 511 (pt 3). 803-811.
15. Kupittayanant S., Luckas MJ, Wray S. Effect of inhibiting the sarcoplasmic reticulum on spontaneous and oxytocin-induced contractions of human myometrium. BJOG. 2002 ; 109 (3). 289-296.
16. Buzdar AU Fulvestrant-a novel estrogen receptor antagonist for the treatment of advanced breast cancer. Drugs Today (Barc). 2008 ; 44 (9). 679-692.
17. Kakui K., Itoh H., Sagawa N., et al. Augmented endothelial nitric oxide synthase (eNOS) protein expression in human pregnant myometrium: possible involvement of eNOS promoter activation by estrogen via both estrogen receptor (ER) alpha and ERbeta. Mol Hum Reprod. 2004 ; 10 (2). 115-122.
18. Cassidy A. Dietary phytoestrogens-potential anti-cancer agents ? BNF Nutr Bull. 1999 ; 24: 22-31.
19. Wray S. Insights into the uterus. Exp Physiol. 2007 ; 92: 621-631.
20. Oishi K., Takano-Ohmuro H., Minakawa-Matsuo N., et al. Oxytocin contracts rat uterine smooth muscle in Ca2+-free medium without any phosphorylation of myosin light chain. Biochem Biophys Res Commun. 1991 ; 176 (1). 122-128.
21. Heaton RC, Wray S., Eisner DA Effects of metabolic inhibition and changes of intracellular pH on potassium permeability and contraction of rat uterus. J Physiol Lond. 1993 ; 465: 43-56.
22. Wray S., Burdyga T., Noble K. Calcium signalling in smooth muscle. Cell Calcium. 2005 ; 38 (3-4). 397-407.
23. Taggart MJ, Wray S. Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: gestational dependence in isolated rat uterus. J Physiol Lond. 1998 ; 511 (pt 1). 133-144.
24. Wang CT, Caruso RL ∝-Tocopherol inhibits activation of the ε isoform of protein kinase C and NADPH oxidase-mediated generation of superoxide anion redicals in lindaneexposed myometrium. Annual Meeting of the Society for the Study of Reproduction, Pullman, WS ; 1999.
25. Zhang J., Kendrick A., Quenby S., Wray S. Contractility and calcium signalling of human myometrium are profoundly affected by cholesterol manipulation: implications for labour ? Reprod Sci. 2007 ; 14 (5). 456-466.
26. Borges AC, Feres T., Vianna LM, Paiva TB Recovery of impaired K+ channels in mesenteric arteries from spontaneously hypertensive rats by prolonged treatment with cholecalciferol. Br J Pharmacol. 1999 ; 127 (3). 772-778.
27. Noble K., Matthew A., Burdyga T., Wray S. A review of recent insights into the role of the sarcoplasmic reticulum and Ca entry in uterine smooth muscle. Eur J Obstet Gynecol Reprod Biol. 2009 ; 144 (suppl 1). 11-19.
28. Burdyga T., Wray S., Noble K. In situ calcium signaling: no calcium sparks detected in rat myometrium. Ann N Y Acad Sci. 2007 ; 1101: 85-96.
29. Olson ML, Kargacin ME, Honeyman TW, Ward CA, Kargacin GJ Effects of phytoestrogens on sarcoplasmic/endoplasmic reticulum calcium ATPase 2a and Ca2+ uptake into cardiac sarcoplasmic reticulum. J Pharmacol Exp Ther. 2006 ; 316 (2). 628-635.
30. Quenby S., Pierce SJ, Brigham S., Wray S. Dysfunctional labor and myometrial lactic acidosis. Obstet Gynecol. 2004 ; 103 (4). 718-723.