Regimen complexity and medication nonadherence in elderly patients

Therapeutics and Clinical Risk Management

Volumn 5, Issue 1, 2009, Pages 209-216

  Corsonello, Andrea ^a   Pedone, Claudio ^c   Lattanzio, Fabrizia ^b   Lucchetti, Maria ^b   Garasto, Sabrina ^a   Carbone, Claudia ^a   Greco, Cosetta ^b   Fabbietti, Paolo ^b   Incalzi, Raffaele Antonelli ^c,d  

^a INRCA   (Italy)

^b Ancona ^*  (Italy)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^d Fondazione San Raffaele   (Italy)

Author keywords

Elderly; Medication adherence; Regimen complexity

Indexed keywords

DRUG;

AGED; ARTICLE; CAREGIVER; COGNITIVE DEFECT; ELDERLY CARE; EMERGENCY CARE; FEMALE; HUMAN; ITALY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRESCRIPTION; REHABILITATION CARE; SELF REPORT; TREATMENT REFUSAL;

EID: 77949459209     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/tcrm.s4870     Document Type: Article

References (55)

1. Dorz S, Lazzarini L, Cattelan A, et al. Evaluation of adherence to antiretroviral therapy in Italian HIV patients. AIDS Patient Care STDS. 2003;17:33-41.
2. Volmink J, Garner P. Systematic review of randomised controlled trials of strategies to promote adherence to tuberculosis treatment. BMJ. 1997;315:1403-1406.
3. Mallion J, Dutrey-Dupagne C, Vaur L, et al. Benefits of electronic pillboxes in evaluating treatment compliance of patients with mild to moderate hypertension. J Hypertens. 1996;14:137-144.
4. Benner J, Glynn R, Mogun H, et al. Long-term persistence in use of statin therapy in elderly patients. JAMA. 2002;288:455-461.
5. Bezie Y, Molina M, Hernandez N, et al. Therapeutic compliance: a prospective analysis of various factors involved in the adherence rate in type 2 diabetes. Diabetes Metab. 2006;32:611-616.
6. Vrijens B, Vincze G, Kristanto P, et al. Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ. 2008;336:1114-1117.
7. Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166:1836-1841.
8. Morrell RW, Park DC, Kidder DP, et al. Adherence to antihypertensive medications across the life span. Gerontologist. 1997;37:609-619.
9. Siegel D, Lopez J, Meier J. Antihypertensive medication adherence in the Department of Veterans Affairs. Am J Med. 2007;120:26-32.
10. Gazmararian JA, Kripalani S, Miller MJ, et al. Factors associated with medication refill adherence in cardiovascular-related diseases: a focus on health literacy. J Gen Intern Med. 2006;21:1215-1221.
11. Inkster ME, Donnan PT, MacDonald TM, Sullivan FM, Fahey T. Adherence to antihypertensive medication and association with patient and practice factors. J Hum Hypertens. 2006;20:295-297.
12. Johnell K, Råstam L, Lithman T, et al. Low adherence with antihypertensives in actual practice: the association with social participation - a multilevel analysis. BMC Public Health. 2005;5:17.
13. Wang PS, Bohn RL, Knight E, et al. Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors. J Gen Intern Med. 2002;17:504-511.
14. Lam PW, Lum CM, Leung MF. Drug non-adherence and associated risk factors among Chinese geriatric patients in Hong Kong. Hong Kong Med J. 2007;13:284-292.
15. Wang PS, Avorn J, Brookhart MA, et al. Effects of noncardiovascular comorbidities on antihypertensive use in elderly hypertensives. Hypertension. 2005;46:273-279.
16. Wamala S, Merlo J, Bostrom G, et al. Socioeconomic disadvantage and primary non-adherence with medication in Sweden. Int J Qual Health Care. 2007;19:134-140.
17. Kammerer J, Garry G, Hartigan M, et al. Adherence in patients on dialysis: strategies for success. Nephrol Nurs J. 2007;34:479-486.
18. Vik SA, Maxwell CJ, Hogan DB. Measurement, correlates and health outcomes of medication adherence among seniors. Ann Pharmacother. 2004;38:303-312.
19. Lexchin J, Grootendorst P. Effects of prescription drug user fees on drug and health services use and on health status in vulnerable populations: a systematic review of the evidence. Int J Health Serv. 2004;34:101-122.
20. Carosella L, Pahor M, Pedone C, et al. Pharmacosurveillance in hospitalized patients in Italy: study design of the Gruppo Italiano di Farmacovigilanza nell'Anziano' (GIFA). Pharmacol Res. 1999;40:287-295.
21. Pahor M, Chrischilles EA, Guralnik JM, et al. Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol. 1994;10:405-411.
22. National Center for Health Statistics. International classification of diseases, ninth revision, clinical modifications. Washington, DC: Public Health Service, Health Care Financing Administration; 1980.
23. Folstein MF, Folstein SE, McHigh PR. "Mini Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
24. Lesher EL, Berryhill JS. Validation of the Geriatric Depression Scale-Short Form among inpatients. J Clin Psychol. 1994;50:256-260.
25. Katz S, Ford AB, Moskowitz RW, et al. Studies of illness in aged: the index of ADL, a standardized measure of biological and psychosocial function. JAMA. 1963;185:94-106.
26. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179-186.
27. Antonelli Incalzi R, Corsonello A, Pedone C, et al. Construct validity of activities of daily living scale: a clue to distinguish the disabling effects of COPD and congestive heart failure. Chest. 2005;127:830-838.
28. Conwell Y, Forbes NT, Cox C, et al. Validation of a measure of physical illness burden at autopsy: the Cumulative Illness Rating Scale. J Am Geriatr Soc. 1993;41:38-41.
29. World Health Organization. International drug monitoring: The role of the hospital. WHO Technical Report Series No. 425. Geneva, Switzerland: World Health Organization; 1969.
30. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-245.
31. Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment: clinical applications. JAMA. 2002;288:2880-2883.
32. Hosmer D, Lemeshow S. Applied logistic regression. New York, NY: John Wiley and Son; 1989.
33. Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med. 2008;31:213-224.
34. Shalansky SJ, Levy AR. Effect of number of medications on cardiovascular therapy adherence. Ann Pharmacother. 2002;36:1532-1539.
35. Nikolaus T, Kruse W, Bach M, Specht-Leible N, Oster P, Schlierf G. Elderly patients' problems with medication. An in-hospital and follow-up study. Eur J Clin Pharmacol. 1996;49:255-259.
36. Lau DT, Briesacher BA, Mercaldo ND, et al. Older patients' perceptions of medication importance and worth: an exploratory pilot study. Drugs Aging. 2008;25:1061-1075.
37. Ayalon L, Kaniel M, Rosenberg L. Social workers' perspectives on care arrangements between vulnerable elders and foreign home care workers: lessons from Israeli/Filipino caregiving arrangements. Home Health Care Serv Q. 2008;27(2):121-142.
38. Cotrell V, Wild K, Bader T. Medication management and adherence among cognitively impaired older adults. J Gerontol Soc Work. 2006;47(3-4):31-46.
39. Wayland C. The failure of pharmaceuticals and the power of plants: medicinal discourse as a critique of modernity in the Amazon. Soc Sci Med. 2004;58:2409-2419.
40. Carpenter GI. Aging in the United Kingdom and Europe - a snapshot of the future? J Am Geriatr Soc. 2005;53(9 Suppl):S310-313.
41. Williams A, Manias E, Walker R. Interventions to improve medication adherence in people with multiple chronic conditions: a systematic review. J Adv Nurs. 2008;63:132-143.
42. Chapman RH, Petrilla AA, Benner JS, Schwartz JS, Tang SS. Predictors of adherence to concomitant antihypertensive and lipid-lowering medications in older adults: a retrospective, cohort study. Drugs Aging. 2008;25:885-892.
43. Wu JR, Moser DK, Chung ML, Lennie TA. Predictors of medication adherence using a multidimensional adherence model in patients with heart failure. J Card Fail. 2008;14(7):603-614.
44. Odegard PS, Gray SL. Barriers to medication adherence in poorly controlled diabetes mellitus. Diabetes Educ. 2008;34(4):692-697.
45. Molloy GJ, Perkins-Porras L, Strike PC, Steptoe A. Social networks and partner stress as predictors of adherence to medication, rehabilitation attendance, and quality of life following acute coronary syndrome. Health Psychol. 2008;27:52-58.
46. Carr AJ, Thompson PW, Cooper C. Factors associated with adherence and persistence to bisphosphonate therapy in osteoporosis: a cross-sectional survey. Osteoporos Int. 2006;17:1638-1644.
47. Park DC, Hertzog C, Leventhal H, et al. Medication adherence in rheumatoid arthritis patients: older is wiser. J Am Geriatr Soc. 1999;47:172-183.
48. Bagchi AD, Esposito D, Kim M, Verdier J, Bencio D. Utilization of, and adherence to, drug therapy among medicaid beneficiaries with congestive heart failure. Clin Ther. 2007;29:1771-1783.
49. Bambauer KZ, Soumerai SB, Adams AS, Zhang F, Ross-Degnan D. Provider and patient characteristics associated with antidepressant nonadherence: the impact of provider specialty. J Clin Psychiatry. 2007;68(6):867-873.
50. Moriski DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24:67-74.
51. Andrade SE, Kahler KH, Frech F, et al. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf. 2006;15:565-574.
52. Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment: clinical applications. JAMA. 2002;288(22):2880-2883.
53. Nelson MR, Reid CM, Ryan P, et al. Self-reported adherence with medication and cardiovascular disease outcomes in the Second Australian National Blood Pressure Study (ANBP2). Med J Aust. 2006;185:487-489.
54. Gehi AK, Ali S, Na B, et al. Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the heart and soul study. Arch Intern Med. 2007;167:1798-1803.
55. Depp CA, Cain AE, Palmer BW, et al. Assessment of medication management ability in middle-aged and older adults with bipolar disorder. J Clin Psychopharmacol. 2008;28:225-229.