Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review)

Oncology Reports

Volumn 23, Issue 4, 2010, Pages 887-892

  Chiarini, Anna ^a   Whitfield, James F ^b   Pacchiana, Raffaella ^a   Marconi, Maddalena ^a   Armato, Ubaldo ^a   Dal Prà, Ilaria ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Apoptogenesis; Human neoplastic cells; Lamins; Perylenequinones; Polyomavirus transformed rat fibroblasts; Reactive oxygen species

Indexed keywords

CALPHOSTIN C; CYTOCHROME C; LAMIN B; LAMIN B1; PROTEASOME; PROTEIN KINASE C; PROTEIN KINASE C DELTA; UNCLASSIFIED DRUG;

APOPTOGENESIS; APOPTOSIS; BREAST CANCER; CELL MEMBRANE; CELL STRESS; CHEMICAL STRUCTURE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; MITOCHONDRION; NONHUMAN; OXIDATION; PHOTODYNAMICS; PRIORITY JOURNAL; REVIEW; TUMOR CELL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL NUCLEUS; HUMANS; LAMIN TYPE B; NAPHTHALENES; PHOTOCHEMOTHERAPY;

EID: 77949429212     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000711     Document Type: Review

References (36)

1. Beck TP, Kirsh EJ, Chmura SJ, Kovar DA, Chung T, Rinker-Schaeffer CW and Stadler WM: In vitro evaluation of calphostin C as a novel agent for photodynamic therapy of bladder cancer. Urology 54: 573-577, 1999.
2. Diwu Z and Lown JW: Photosensitization with anticancer agents. 15. Perylenequinoid pigments as potential photodynamic therapeutic agents: formation of semiquinone radicals and reactive oxygen species on illumination. J Photochem Photobiol B 18: 131-143, 1993.
3. Gomer CJ: Preclinical examination of first and second generation photosensitizers used in photodynamic therapy, Photochem Photobiol 54: 1093-1107, 1991.
4. Kaul A and Maltese WA: Killing of cancer cells by the photo-activatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. Neoplasia 11: 823-834, 2009.
5. Olivo M and Ali-Seyed M: Apoptosis signaling mechanisms in human cancer cells induced by calphostin-PDT. Int J Oncol 30: 537-548, 2007.
6. Sanovic R, Krammer B, Grumboeck S and Verwanger T: Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin. Int J Oncol 35: 921-939, 2009.
7. Bruns RF, Miller FD, Merriman RL, Howbert JJ, Heath WF, Kobayashi E, Takahashi I, Tamaoki T and Nakano H: Inhibition of protein kinase C by calphostin C is light-dependent. Biochem Biophys Res Commun 176: 288-293, 1991.
8. Gopalakrishna R, Chen ZH and Gundimeda U: Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett 314: 149-154, 1992.
9. Kobayashi E, Ando K, Nakano H and Tamaoki T: UCN-1028A, a novel and specific inhibitor of protein kinase C from Cladosporium. J Antibiotics (Tokyo) 42: 153-155, 1989.
10. Kobayashi E, Nakano H, Morimoto M and Tamaoki T: Calphostin C (UCN-1028c), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159: 548-553, 1989.
11. Pollack IF and Kawecki S: The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J Neurooncol 31: 255-266, 1997.
12. Takao I, Kobayashi E, Yoshida M and Sano H: Calphostins, novel and specific inhibitors of protein kinase C. B. Chemical structures. J Antibiotics (Tokyo) 42: 1475-1481, 1989.
13. Gueded RC and Eriksson LA: Photophysics, photochemistry, and reactivity: molecular aspects of perylenequinone reactions. Photochem Photobiol Sci 6: 1089-1096, 2007.
14. Chiarini A, Whitfield JF, Pacchiana R, Armato U and Dal Pra I: Photoexcited calphostin C selectively destroys nuclear lamin B1 in neoplastic human and rat cells. A novel mechanism of action of a photodynamic tumor therapy agent. Biochim Biophys Acta 1783: 1642-1653, 2008.
15. Bridger JM, Foeger N, Kill LR and Hermann H: The nuclear lamina. Both a structural framework and a platform for genome organization. FEBS J 274: 1354-1361, 2007.
16. Dechat T, Pfleghaar K, Sengupta K, Shimi T, Schumaker DK, Solimando L and Goldman RD: Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev 22: 832-853, 2008.
17. Goldberg MW, Fiserova J, Huttenlauch I and Stick R: A new model for nuclear lamina organization. Biochem Soc Trans 36: 1339-1343, 2008.
18. Larijani B and Poccia DL: Nuclear envelope formation: mind the gaps. Annu Rev Biophys 38: 107-124, 2009.
19. Goldman RD, Gruenbaum Y, Moir RD, Schumaker DK and Spann TP: Nuclear lamins: building blocks of nuclear architecture. Genes Dev 16: 533-547, 2002.
20. Gruenbaum Y, Margalit A, Goldman RD, Schumaker DK and Wilson KL: The nuclear lamin comes of age. Nat Rev Mol Cell Biol 6: 21-31, 2005.
21. Heessen S and Fornerod M: The inner nuclear envelope as a transcription factor resting place. EMBO Rep 8: 914-919, 2007.
22. Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM and Lammerding J: Cell nuclei spin in the absence of lamin B1. J Biol Chem 282: 20015-20026, 2007.
23. Harborth J, Elbashir SM, Bechert K, Tuschl T and Weber K: Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 114: 4557-4565, 2001.
24. Carlson MW, Iyer VR and Marcotte EM: Quantitative gene expression assessment identifies appropriate cell line models for individual cervical cancer pathways. BMC Genomics 8: 117, 2007.
25. Dal Pra I, Whitfield JF, Chiarini A and Armato U: Increased activity of the protein kinase-‰ holoenzyme in the cytoplasmic particulate fraction precedes activation of caspases in the polyomavirus-transformed pyF111 rat fibroblasts exposed to calphostin C or topoisomerase II inhibitors. Exp Cell Res 255: 171-183, 2000.
26. Mehta IS, Elcock LS, Amira M, Kill IR and Bridger JM: Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link? Biochem Soc Trans 36: 1384-1388, 2008.
27. I in polyomavirus-transformed pyF111 rat fibroblasts. Int J Mol Med 17: 111-120, 2006.
28. Yan N and Shi Y: The mechanisms of apoptosis through structural biology. Annu Rev Cell Dev Biol 21: 35-56, 2005.
29. Jung T and Grune T: The proteasome and its role in the degradation of oxidized proteins. IUBMB Life 60: 743-752, 2008.
30. II is an apoptotic lamin kinase in polyomavirus-transformed etoposide-treated pyF111 rat fibroblasts. J Biol Chem 277: 18827-18839, 2002.
31. Reyland ME: Protein kinase C-δ and apoptosis. Biochem Soc Trans 35 (Pt. 5): 1001-1004, 2007.
32. Da Rocha AB, Mans DRA, Regner A and Schwartsmann G: Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? Oncologist 7: 17-33, 2002.
33. Whitfield JF and Chakravarthy B: Calcium: The Grand-Master Cell Signaller. NRC Research Press, Ottawa, 2001.
34. Newton AC: Protein kinase C: structure, function and regulation. J Biol Chem 270: 28495-28498, 1995.
35. Rotenberg SA, Huang MH, Zhu J, Su L and Riedel H: Deletion analysis of protein kinase C inactivation by calphostin C. Mol Carcinogenesis 12: 42-49, 1995.
36. Chan JY, Chang AY, Wang LL, Ou CC and Chan SH: Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia. Mol Pharmacol 71: 1129-1139, 2007.