Male infertility caused by epididymal dysfunction in transgenic mice expressing a dominant negative mutation of retinoic acid receptor α

Biology of Reproduction

Volumn 56, Issue 4, 1997, Pages 985-990

  Costa, Stacy L ^a   Boekelheide, Kim ^b   Vanderhyden, Barbara C ^a   Seth, Rahul ^b   McBurney, Michael W ^a  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID RECEPTOR; RETINOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; EPIDIDYMIS DISEASE; FEMALE; GENE EXPRESSION; GENE MUTATION; MALE; MALE INFERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL METAPLASIA; TRANSGENIC MOUSE; VAS DEFERENS;

ANIMALS; EPIDIDYMIS; FEMALE; GENES, DOMINANT; GENES, MYC; HUMANS; IMMUNOHISTOCHEMISTRY; INFERTILITY, MALE; KERATINS; LITTER SIZE; MALE; MAMMARY TUMOR VIRUS, MOUSE; METAPLASIA; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; MUTATION; PROMOTER REGIONS (GENETICS); RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; SPERMATOZOA; VAS DEFERENS;

EID: 0030978644     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod56.4.985     Document Type: Article

References (38)

1. Wong PY. Abnormal fluid transport by the epididymis as a cause of obstructive azoospermia. Review. Reprod Fertil Dev 1990; 2:115-127.
2. Griswold MD, Bishop PD, Kim K-H, Ping R, Siiteri JE, Morales C. Function of vitamin A in normal and synchronized seminiferous tubules. Ann NY Acad Sci 1989; 564:154-172.
3. Blomhoff R, Green MH, Norum KR. Vitamin A: physiological and biochemical processing. Annu Rev Nutr 1992; 12:37-57.
4. Goss GD, McBurney MW. Physiological and clinical aspects of vitamin A and its metabolites. Crit Rev Clin Lab Sci 1992; 29:185-215.
5. Petkovich M, Brand NJ, Krust A, Chambon P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 1987; 330:444-450.
6. Giguère V, Ong RS, Segui P, Evans RM. Identification of a receptor for the morphogen retinoic acid. Nature 1987; 330:624-629.
7. Brand NJ, Petkovich M, Krust A, Chambon P, De Thé H, Marchio A, Tiollais P, Dejean A. Identification of a second human retinoic acid receptor. Nature 1988; 332:850-853.
8. Benbrook D, Lernhardt E, Pfahl M. A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature 1988; 333:669-672.
9. Schubert D, Kimura H, LaCorbiere M, Vaughan J, Karr D, Fischer WH. Activin is a nerve cell survival molecule. Nature 1990; 344:868-870.
10. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry R Gaub M-P, LeMeur M, Chambon P. High postnatal lethality and testis degeneration in retinoic acid receptor a mutant mice. Proc Natl Acad Sci USA 1993; 90:7225-7229.
11. Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM. RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes & Dev 1994; 8:1007-1018.
12. Mendelsohn C, Mark M, Dollé P, Dierich A, Gaub MP, Krust A, Lampron C, Chambon P. Retinoic acid receptor β2 (RARβ2) null mutant mice appear normal. Dev Biol 1994; 166:246-258.
13. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P. Function of retinoic acid receptor gamma in the mouse function of retinoic acid receptor gamma in the mouse. Cell 1993; 73:643-658.
14. Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Décimo D, Krezel W, Dierich A, Chambon P. Abnormal spermatogenesis in RXRβ mutant mice. Genes & Dev 1996; 10:80-92.
15. Stewart TA, Pattengale PK, Leder P. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express mtv/myc fusion genes. Cell 1984; 38:627-637.
16. Leder A, Pattengale PK, Kuo A, Stewart TA, Leder P. Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 1986; 45:485-495.
17. Stocklin E, Botteri F, Groner B. An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice. J Cell Biol 1993; 122:199-208.
18. Tutrone RF Jr, Ball RA, Ornitz DM, Leder P, Richie JP. Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model. J Urol 1993; 149:633-639.
19. Costa SL, McBurney MW. Dominant negative mutant of retinoic acid receptor a inhibits retinoic acid-induced P19 cell differentiation by binding to DNA. Exp Cell Res 1996; 225:35-43.
20. Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumours by expression of polyoma middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 1992; 12:954-961.
21. Hogan B, Costantini F, Lacy E. Manipulating the Mouse Embryo. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1986: 1.
22. Laird PW, Zidjerveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A. Simplified mammalian DNA isolation procedure. Nucleic Acids Res 1991; 19:4293.
23. Chatot CL, Ziomek CA, Bavister BD, Lewis JL, Torres I. An improved culture medium supports development of random-bred 1-cell mouse embryos in vitro. J Reprod Fertil 1989; 86:679-688.
24. Chapin RE, Ross MD, Lamb JC. Immersion fixation methods for glycol methacrylate-embedded testes. Toxicol Pathol 1984; 12:221-227.
25. Morassutti DJ, Staines WA, Magnuson DSK, Marshall KC, McBurney MW. Murine embryonal carcinoma-derived neurons survive and mature following transplantation into adult rat striatum. Neuroscience 1994; 58:753-763.
26. Kemler R, Brulet P, Schnebelen MT, Gaillard J, Jacob F. Reactivity of monoclonal antibodies against intermediate filament proteins during embryonic development. J Embryol Exp Morphol 1981; 64:45-60.
27. Auffray C, Rougeon F. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 1980; 107:303-314.
28. McBurney MW, Staines WA, Boekelheide K, Parry D, Jardine K, Pickavance L. The murine Pgk-1 promoter drives widespread but not uniform expression in transgenic mice. Dev Dynam 1994; 200:278-293.
29. Evan GI, Lewis GK, Ramsay G, Bishop JM. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol 1985; 5:3610-3616.
30. Look J, Landwehr J, Bauer F, Hoffmann AS, Bluethmann H, LeMotte P. Marked resistance of RAR gamma-deficient mice to the toxic effects of retinoic acid. Am J Physiol 1995; 269:E91-98.
31. Wan YJ, Wang L, Wu TC. Detection of retinoic acid receptor mRNA in rat tissues by reverse transcriptase-polymerase chain reaction. J Mol Endocrinol 1992; 9:291-294.
32. Akmal KM, Dufour JM, Kim KH. Region-specific localization of retinoic acid receptor-α expression in the rat epididymis. Biol Reprod 1996; 54:1111-1119.
33. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240:889-895.
34. Lohnes D, Mark M, Mendelsohn C, Dolle P, Decimo D, LeMeur M, Dierich, A, Gorry P, Chambon P. Developmental roles of the retinoic acid receptors. Review. J Steroid Biochem Mol Biol 1995; 53:475-486.
35. Lohnes D, Mark M, Mendelsohn C, Dollé P, Dierich A, Gorry P, Gansmuller A, Chambon P. Function of the retinoic acid receptors (RARs) during development. (I) Craniofacial and skeletal abnormalities in RAR double mutants. Development 1994; 120:2723-2748.
36. Mendelsohn C, Lohnes D, Décimo D, Lufkin T, LeMeur M, Chambon P, Mark M. Function of the retinoic acid receptors (RARs) during development. (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 1994; 120:2749-2771.
37. Saitou M, Sugai S, Tanaka T, Shimouchi K, Fuchs E, Narumiya S, Kakizuka A. Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 1995; 374:159-162.
38. Imakado S, Bickenbach JR, Bundman DS, Rothnagel JA, Attar PS, Wang X-J, Walczak VR, Wisniewski S, Pole J, Gordon JS, Heyman RA, Evans RM, Roop DR. Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Genes & Dev 1995; 9:317-329.