Postmortem increase of flecainide level in cardiac blood

Journal of Analytical Toxicology

Volumn 32, Issue 6, 2008, Pages 451-453

  Yoshitome, Kei ^a   Miyaishi, Satoru ^a   Yamamoto, Yuji ^a   Ishizu, Hideo ^b  

^a OKAYAMA UNIVERSITY   (Japan)

^b KAWASAKI UNIVERSITY OF MEDICAL WELFARE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FLECAINIDE;

AGED; ARTICLE; ARTIFICIAL HEART PACEMAKER; AUTOPSY; BLOOD SAMPLING; CADAVER; CASE REPORT; CONGESTIVE HEART FAILURE; CORONARY ARTERY BLOOD FLOW; DEATH; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG MEGADOSE; DRUG OVERDOSE; GAIT DISORDER; HUMAN; MALE; PH; RESUSCITATION; SICK SINUS SYNDROME; TREATMENT DURATION; VOMITING;

EID: 48249098292     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/32.6.451     Document Type: Article

References (19)

1. M. Takada, T. Goto, T. Kotake, M. Saito, N. Kawato, M. Nakai, T. Gunji, and M. Shibakawa. Appropriate dosing of antiarrhythmic drugs in Japan requires therapeutic drug monitoring. J. Clin. Pharm. Ther. 30(1): 5-12 (2005).
2. M.J. Lynch and J. Gerostamoulos. Flecainide toxicity: cause and contribution to death. Leg. Med. 3(4): 233-236 (2001).
3. L.B. Mitchell. Use of the newer antiarrhythmic drugs in patients with supraventricular tachyarrhythmias: let's not throw out the baby with the bath water. Can. J. Cardiol. 12(10): 972-982 (1996).
4. J.J. O'Sullivan, P.T. McCarthy, and C. Wren. Differences in amiodarone, digoxin, flecainide and sotalol concentrations between antemortem serum and femoral postmortem blood. Hum. Exp. Toxicol. 14(7): 605-608 (1995).
5. U. Hoppe, B. Krudewagen, H. Stein, R. Hertrampf, and U. Gundert-Remy. Comparison of fluorescence polarisation immunoassay (FPIA) and high performance liquid chromatography (HPLC) methods for the measurement of flecainide in human plasma. Int. J. Clin. Pharmacol. Ther. Toxicol. 31(3): 142-147 (1993).
6. F. Broly, P. Marecaux, N. Houdret, M. Lhermitte, and R. Houssin. A high performance liquid chromatographic method for the quantitation of flecainide in plasma. Biomed. Chromatogr. 5(6): 248-250(1991).
7. H. Atarashi, H. Saito, T. Onodera, Y. Kobayashi, M. Koh, H. Sasaki, M. Yasutake, H. Hayakawa, M. Shimomura, and N. Morishita. The phase I trial of flecainide acetate, a new antiarrhythmic agent. Jpn. J. Clin. Pharmacol. Therapeut. 19(3): 563-572 (1988).
8. B. Levine, D. Chute, and Y.H. Caplan. Flecainide intoxication. J. Anal. Toxicol. 14(5): 335-336 (1990).
9. A.R. Forrest, I. Marsh, J.H. Galloway, and P.B. Gray. A rapidly fatal overdose with flecainide. J. Anal. Toxicol. 15(1): 41-43 (1991).
10. N. Romain, C. Giroud, K. Michaud, M. Augsburger, and P. Mangin. Fatal flecainide intoxication. Forensic Sci. Int. 106(2): 115-123(1999).
11. D.J. Pounder and D.R. Smith. Postmortem diffusion of alcohol from the stomach. Am. J. Forensic Med. Pathol. 16(2): 89-96 (1995).
12. C. Fuke, C.L. Berry, and D.J. Pounder. Postmortem diffusion of ingested and aspirated paint thinner. Forensic Sci. Int. 78(3): 199-207(1996).
13. T. Hilberg, A. Bugge, K.M. Beylich, J. Ingum, A. Bjørneboe, and J. Mørland. An animal model of postmortem amitriptyline redistribution.J. Forensic Sci. 38(1): 81-90 (1993).
14. D.J. Pounder, C. Fuke, D.E. Cox, D. Smith, and N. Kuroda. Postmortem diffusion of drugs from gastric residue: an experimental study. Am. J. Forensic Med. Pathol. 17(1): 1-7 (1996).
15. F. Moriya and Y. Hashimoto. Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem. /, Forensic Sci. 44(1): 10-16 (1999).
16. F. Moriya and Y. Hashimoto. Redistribution of diltiazem in the early postmortem period. J. Anal. Toxicol. 28(4): 269-271 (2004).
17. W.W. Jetter. Post-mortem biochemical changes, J. Forensic Sci. 4: 330-341 (1959).
18. R. Kannan and A. Matin-Asgari. Dose-dependent tissue uptake of flecainide during chronic administration in rabbits. Drug Metab. Dispos. 16(2): 228-231 (1988).
19. R. Latini, A. Cavalli, A.P. Maggioni, and A. Volpi. Flecainide distribution in human tissues. Br. j. Clin. Pharmacol. 24(6): 820-822 (1987).