Preliminary results of prognostic significance of proliferating cell nuclear antigen expression in advanced primary larynx carcinomas and lymph node metastases

Archives of Medical Science

Volumn 6, Issue 1, 2010, Pages 65-70

  Kupisz, Krzysztof ^a   Stepulak, Andrzej ^b,c   Zdunek, Małgorzata ^b   Klatka, Janusz ^b  

^a Jan Bozy District Hospital   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^c Ministry of Interior and Administration Republic of Poland Central Clinical Hospital   (Poland)

Author keywords

Larynx cancer; Metastases; Proliferating cell nuclear antigen

Indexed keywords

CYCLINE;

ADULT; ADVANCED CANCER; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE;

EID: 77949395643     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2010.13509     Document Type: Article

References (28)

1. Anzai Y, Brunberg JA, Lufkin RB. Imaging of nodal metastases in the head and neck. J Magn Reson Imaging 1997; 7: 774-83.
2. Galioto GB, Mevio E, Benazzo M, et al. Prognostic parameters in metastatic spread of laryngeal cancer: clinico-histopathological correlations. Clin Otolaryngol Allied Sci 1987; 12: 303-8.
3. Kau RJ, Alexiou C, Stimmer H, et al. Diagnostic procedures for detection of lymph node metastases in cancer of the larynx. ORL J Otorhinolaryngol Relat Spec 2000; 62: 199-203.
4. Pich A, Chiusa L, Navone R. Prognostic relevance of cell proliferation in head and neck tumors. Ann Oncol 2004; 15: 1319-29.
5. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182: 311-22.
6. Jonsson ZO, Hubscher U. Proliferating cell nuclear antigen: more than a clamp for DNA polymerases. Bioessays 1997; 19: 967-75.
7. Mathews MB, Bernstein RM, Franza BR Jr., et al. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984; 309: 374-6.
8. Kimos MC, Wang S, Borkowski A, et al. Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression. Int J Cancer 2004; 111: 415-7.
9. Taftachi R, Ayhan A, Ekici S, et al. Proliferating-cell nuclear antigen (PCNA) as an independent prognostic marker in patients after prostatectomy: a comparison of PCNA and Ki-67. BJU Int 2005; 95: 650-4.
10. Wang JL, Zheng BY, Li XD, et al. Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer. Clin Cancer Res 2004; 10: 2407-14.
11. Boran C, Yildiz L, Kandemir B, et al. Correlation of proliferating cell nuclear antigen and bcl-2 expression with tumor front grading and metastasis in laryngeal squamous cell carcinoma. Neoplasma 2003; 50: 139-43.
12. Dobros W, Rys J, Niezabitowski A, et al. The prognostic value of proliferating cell nuclear antigen (PCNA) in the advanced cancer of larynx. Auris Nasus Larynx 1998; 25: 295-301.
13. Franchi A, Gallo O, Boddi V, et al. Prediction of occult neck metastases in laryngeal carcinoma: role of proliferating cell nuclear antigen, MIB-1, and E-cadherin immuno-histochemical determination. Clin Cancer Res 1996; 2: 1801-8.
14. Liu M, Lawson G, Delos M, et al. Prognostic value of cell proliferation markers, tumour suppressor proteins and cell adhesion molecules in primary squamous cell carcinoma of the larynx and hypopharynx. Eur Arch Otorhinolaryngol 2003; 260: 28-34.
15. Liu M, Lawson G, Delos M, et al. Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: comparison with clinical and radiologic examinations. Head Neck 2003; 25: 280-8.
16. Liu M, Lawson G, Delos M, et al. Evaluation of proliferating cell nuclear antigen (PCNA) in supraglottic carcinoma. Acta Otorhinolaryngol Belg 1997; 51: 129-35.
17. Sarac S, Ayhan A, Hosal AS, et al. Prognostic significance of PCNA expression in laryngeal cancer. Arch Otolaryngol Head Neck Surg 1998; 124: 1321-4.
18. Laitakari J, Harrison D, Stenback F. Automated image analysis of proliferating cells in carcinoma of the larynx. Acta Otolaryngol 2003; 123: 759-66.
19. Zidar N, Gale N, Cor A, et al. Expression of Ki-67 antigen and proliferative cell nuclear antigen in benign and malignant epithelial lesions of the larynx. J Laryngol Otol 1996; 110: 440-5.
20. Morawski K, Gabriel A, Namyslowski G, et al. Clinical application of proliferating cell nuclear antigen, oncoprotein p53 and tumor front grading analysis in patients operated on for laryngeal cancer. Eur Arch Otorhinolaryngol 1999; 256: 378-83.
21. Bayazit Y, Bakir K, Ucak R, et al. Clinical and histo-pathological correlates of the proliferative activity in squamous cell laryngeal carcinoma. Rev Laryngol Otol Rhinol (Bord) 2002; 123: 43-6.
22. Grzanka A, Sujkowska R, Janiak A, et al. Immunogold labelling of PCNA and Ki-67 antigen at the ultrastructural level in laryngeal squamous cell carcinoma and its correlation with lymph node metastasis and histological grade. Acta Histochem 2000; 102: 139-49.
23. Dong Y, Sui L, Tai Y, et al. The overexpression of cyclin-dependent kinase (CDK) 2 in laryngeal squamous cell carcinomas. Anticancer Res 2001; 21: 103-8.
24. Dong Y, Sui L, Watanabe Y, et al. Aberrant expression of cyclin A in laryngeal squamous cell carcinoma. Anticancer Res 2002; 22: 83-9.
25. Dong Y, Sui L, Tai Y, et al. Prognostic significance of cyclin E overexpression in laryngeal squamous cell carcinomas. Clin Cancer Res 2000; 6: 4253-8.
26. Dong Y, Sui L, Sugimoto K, et al. Cyclin D1-CDK4 complex, a possible critical factor for cell proliferation and prognosis in laryngeal squamous cell carcinomas. Int J Cancer 2001; 95: 209-15.
27. Buyukbayram H, Cureoglu S, Arslan A, et al. Prognostic value of PCNA and mutant p53 expression in laryngeal squamous cell carcinoma. Cancer Invest 2004; 22: 195-202.
28. Jacob R, Welkoborsky HJ, Bittinger F, et al. Histological grading, growth fraction and DNA-ploidy as criteria for the treatment of pharyngeal and supraglottic squamous cell carcinomas: a preliminary, prospective study. ORL J Otorhinolaryngol Relat Spec 2001; 63: 314-20.