Prognostic value of PCNA and mutant p53 expression in laryngeal squamous cell carcinoma

Cancer Investigation

Volumn 22, Issue 2, 2004, Pages 195-202

  Buyukbayram, Huseyin ^a   Cureoglu, Sebahattin ^a   Arslan, Adem ^a   Işikakdogan, A Rahman ^a  

^a DICLE UNIVERSITY   (Turkey)

Author keywords

Laryngeal squamous cell carcinoma; p53; PCNA; Survival

Indexed keywords

CYCLINE; DNA; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOME 17P; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADULT; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION PROFILING; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2642549983     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.1081/CNV-120030207     Document Type: Article

References (25)

1. Parkin, D.M.; Stjensward, J.; Muir, C.S. Estimates of the worldwide frequency of twelve major cancers. Bull. World Health Organ. 1984, 62, 163-182.
2. Yilmaz, T.; Hosal, A.S.; Gedikoglu, G.; Kaya, S. Prognostic significance of histopathological parameters in cancer of the larynx. Eur. Arch. Otorhinolaryngol. 1999, 256, 139-144.
3. Chang, F.; Syrjanen, S.; Syrainen, K. Implications of the p53 tumor-suppressor gene in clinical oncology. J. Clin. Oncol. 1995, 13, 1009-1022.
4. Finlay, C.A.; Hinds, P.W.; Tan, T.H.; Eliyahu, D.; Oren, M.; Levine, A.L. Activation mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half life. Mol. Cell. Biol. 1988, 8, 531.
5. Maestro, R.; Dolcetti, R.; Gasparotto, D.; Doglioni, C.; Pelucchi, S.; Barzan, L.; Grandi, E.; Boiocchi, M. High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene 1992, 7, 1159-1166.
6. Youssef, E.M.; Matsuda, T.; Takada, N.; Osugi, H.; Higashino, M.; Kinoshita, H.; Watanabe, T.; Katsura, Y.; Wanibuchi, H.; Fukushima, S. Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus. Cancer 1995, 76, 358-366.
7. Peruno, M.; Kennth, W.; Janos, W.; Christer, B. Expression of proliferating cell nuclear antigen (PCNA) in urinary bladder carcinoma. Evaluation of antigen retrieval methods. APMIS 1992, 100, 988-992.
8. Sasano, H.; Miyazaki, S.; Gooukon, Y.; Nishihira, T.; Sawai, T.; Nagura, H. Expression of p53 in human esophageal carcinoma: an immunohistochemical study with correlation to proliferating cell nuclear antigen expression. Human Pathol. 1992, 23, 1238-1243.
9. Haapasalo, H.; Isola, J.; Sallinen, P.; Kalimo, H.; Helin, H.; Rantala, I. Aberrant p53 expression in astrocytic neoplasms of the brain: association with proliferation. Am. J. Pathol. 1993, 142, 1347-1351.
10. Ahomadegbe, J.C.; Barrois, M.; Fogel, S.; LeBihan, M.L.; Douc-Rasy, S.; Duvillard, P.; Armand, J.P.; Riou, P. High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early non-invasive lesions. Oncogene 1995, 10, 1217-1227.
11. Nadal, A.; Campo, E.; Pinto, J.; LeBihan, M.L.; Douc-Rasy, S.; Duvillard, P.; Armand, J.P.; Riou, P. p53 expression in normal dysplastic and neoplastic laryngeal epithelium. Absence of correlation with prognostic factors. J. Pathol. 1995, 175, 181-188.
12. UICC International Union Against Cancer: TNM Classification of Malignant Tumors, 4th ed.; Hermanek, P., Sobin, L. H., Eds.; UICC, 1992. rev 2.
13. Hirvikoski, P.; Kumpulainen, E.; Virtaniem, J.; Johansson, R.; Haapasalo, H.; Marin, S.; Halonen, P.; Helin, H.; Raitiola, H.; Pukander, J.; Kellokumpu-Lehtinen, P.; Kosma, V.M. p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma. J. Clin. Oncol. 1997, 15, 3111-3120.
14. Thompson, A.C.; Bradley, P.J.; Griffin, N.R. Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx. Am. J. Surg. 1994, 168, 469-471.
15. Dolcetti, R.; Doglioni, C.; Maestro, R.; Gasparotto, D.; Barzan, L.; Pastore, A.; Romanelli, M.; Boiocchi, M. p53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: Genetic and prognostic implications. Int. J. Cancer 1992, 52, 178-18229.
16. Tomasino, R.M.; Morello, V.; Bazan, V.; Morello, V.; Tralongo, V.; Nuara, R.; Nagar, C.; Salvato, M.; Ingria, F.; Restivo, S. p53 expression in stage III-IV squamous-cell carcinoma of the larynx: an immunohistochemical study related to clinicopathological, flow-cytometric DNA analysis and prognosis. Int. J. Oncol. 1994, 5, 495-500.
17. Jin, Y.T.; Kayser, S.; Kemp, B.L.; Ordonez, N.G.; Tucker, S.L.; Clayman, G.L.; Goepfert, H.; Luna, M.A.; Batsakis, J.G.; El-Naggar, A.K. The prognostic significance of the biomarkers p21WAF1/CIPI, p53, and bcl-2 in laryngeal squamous cell carcinoma. Cancer 1998, 82 (11), 2159-2165.
18. Field, J.K.; Malliri, A.; Butt, S.A.; Gosney, J.R.; Philips, D.E.; Spandidos, D.A.; Jones, A.S. p53 expression in end stage squamous cell carcinoma of the head and neck prior to chemotherapy treatment: expression correlates with a very poor clinical outcome. Int. J. Oncol. 1993, 3, 431-435.
19. Joypaul, B.V.; Hopwood, D.; Newman, E.L.; Qureshi, S.; Grant, A.; Ogston, S.A.; Lane, D.P.; Cuschieri, A. The prognostic significance of the accumulation of p53 tumor-suppressor gene protein in gastric adenocarcinoma. Br. J. Cancer 1994, 69, 943-946.
20. Golusinski, W.; Szmeja, Z.; Olofsson, J.; Biczysko, W.; Krygier-Stojalzowska, A.; Majewski, P. Retrospective analysis of selected tumor markers (p53, PCNA, Ki67; DNA ploidy) and ultrastructure in patients with larynx carcinomas. HNO 1998, 46, 233-240.
21. Golusinski, W.; Olofsson, J.; Szmeja, Z.; Szyfter, K.; Szyfter, W.; Biczysko, W.; Hemminki, K. Alteration of p53 gene structure and function in laryngeal squamous cell cancer. Eur. Arch. Otorhinolaryngol. 1997, 254, 133-137.
22. Chauvel, P.; Courdi, A.; Gioanni, J.; Vallicioni, J.; Santini, J.; Dernard, F. The labelling index: a prognostic factor in head and neck carcinoma. Radiother. Oncol. 1989, 14, 231-237.
23. Welkoborsky, H.J.; Hinni, M.; Dienes, H.P.; Mann, W.J. Predicting recurrence and survival in patients with laryngeal cancer by means of DNA cytometry, tumor front grading, and proliferation markers. Ann. Otol. Rhinol. Laryngol. 1995, 104, 503-510.
24. Urpegui Garcia, A.M.; Morandeira Garcia, M.J.; Soria Navarro, J.; Rivas Rodriguez, P.; Valencia Julve, J.; Fernandez Larripa, S.; Valles Varela, H. Immunohistochemical markers of cell proliferation in laryngeal carcinoma. Acta Otorrinolaringol. Esp. 2000, 51, 279-287.
25. Dobros, W.; Rys, J.; Niezabitowski, A.; Olszewski, E. The prognostic value of proliferating cell nuclear antigen (PCNA) in the advanced cancer of larynx. Auris, Nasus, Larynx 1998, 25, 295-301.