Prolonged medically recorded treatment interruptions among HIV-infected patients on highly active antiretroviral therapy with controlled viremia: When physicians have to juggle patient negotiation and guidelines

Journal of Acquired Immune Deficiency Syndromes

Volumn 53, Issue 4, 2010, Pages 544-546

  Protopopescu, Camelia ^a,b,c   Roux, Perrine ^a,b,c   Carrieri, Maria Patrizia ^a,b,c   Katlama, Christine ^d   Collin, Fidéline ^e   Besnier, Jean Marc ^f   Chêne, Geneviève ^e   Raffi, François ^g   Spire, Bruno ^a,b,c   Leport, Catherine ^h  

^a AIX MARSEILLE UNIV   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c OBSERVATOIRE RÉGIONAL DE LA SANTÉ PROVENCE ALPES CÔTE D AZUR   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e INSERM   (France)

^f CHU BRETONNEAU   (France)

^g HÔTEL DIEU   (France)

^h BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL THERAPY; CD4 LYMPHOCYTE COUNT; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; PHYSICIAN; PRACTICE GUIDELINE; PRIORITY JOURNAL;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; FEMALE; GUIDELINE ADHERENCE; HIV INFECTIONS; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; TREATMENT OUTCOME; VIRAL LOAD; VIREMIA; WITHHOLDING TREATMENT;

EID: 77949383279     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181ba1c48     Document Type: Letter

References (18)

1. Cardiello PG, Hassink E, Ananworanich J, et al. A prospective, randomized trial of structured treatment interruption for patients with chronic HIV type 1 infection. Clin Infect Dis. 2005;40:594-600
2. Fixed duration interruptions are inferior to continuous treatment in African adults starting therapy with CD4 cell counts 200 cells/ microl. AIDS. 2008;22:237-247
3. Pogany K, van Valkengoed IG, Prins JM, et al. Effects of active treatment discontinuation in patients with a CD4+ T-cell nadir greater than 350 cells/mm3: 48-week Treatment Interruption in Early Starters Netherlands Study (TRIESTAN). J Acquir Immune Defic Syndr. 2007;44:395-400.
4. El-Sadr WM, Lundgren JD, Neaton JD, et al. CD4+ count- guidedinterruptionofantiretroviral treatment.N Engl J Med. 2006;355:2283-2296.
5. Danel C, Moh R, Minga A, et al. CD4-guided structured antiretroviral treatment interruption strategy in HIV-infected adults in west Africa (Trivacan ANRS 1269 trial): a randomised trial. Lancet. 2006;367:1981-1989.
6. Hammer SM, Eron JJ Jr, Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008recommendationsoftheInternationalAIDS Society-USA panel. JAMA. 2008;300:555-570.
7. Glass TR, De Geest S, Weber R, et al. Correlates of self-reported nonadherence to antiretroviral therapy in HIV-infected patients: the Swiss HIV Cohort Study. J Acquir Immune Defic Syndr. 2006;41:385-392.
8. Prentice RL, Williams BJ, Peterson AV. On the regression analysis of multivariate failure time data. Biometrika. 1981;68:373-379.
9. Lin DY. Cox regression analysis of multivariate failure time data: the marginal approach. Stat Med. 1994;13:2233-2247.
10. Cleves M. Analysis of Multiple Failure-Time Data With Stata. 1999;STB-49:30-39.
11. Stata. Stata Base Reference Manual, Release 9. College Station, TX: StataCorp LP; 2007.
12. Yéni P. Prise en charge médicale des personnes infectées par le VIH: recommandations du groupe d'experts. Rapport 2006. France: Flammarion; 2006.
13. Young J, De Geest S, Spirig R, et al. Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study. BMJ. 2004;328:15.
14. Carder PC, Vuckovic N, Green CA. Negotiating medications: patient perceptions of long-term medication use. J Clin Pharm Ther. 2003; 28:409-417.
15. Holt M. Agency and dependency within treatment: drug treatment clients negotiating methadone and antidepressants. Soc Sci Med. 2007;64:1937-1947.
16. Benarde MA, Mayerson EW. Patient-physician negotiation. JAMA. 1978;239:1413-1415.
17. Carrieri MP, Leport C, Protopopescu C, et al. Factors associated with nonadherence to highly active antiretroviral therapy: a 5-year follow-up analysis with correction for the bias induced by missing data in the treatment maintenance phase. J Acquir Immune Defic Syndr. 2006;41:477-485.
18. Ananworanich J, Hirschel B. Intermittent therapy for the treatment of chronic HIV infection. AIDS. 2007;21:123-134.