Trials and tribulations of an African-led research and capacity development programme: The case for EDCTP investments

Tropical Medicine and International Health

Volumn 15, Issue 4, 2010, Pages 489-494

  Zumla, A ^a,b   Huggett, J ^a   Dheda, K ^a,b   Green, C ^a   Kapata, N ^a,c   Mwaba, P ^a,d  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c MINISTRY OF HEALTH   (Zambia)

^d UNIVERSITY TEACHING HOSPITAL   (Zambia)

Author keywords

African scientists; Capacity development; European and developing countries clinical trials partnership; Funding; Research; Sub Saharan Africa; Training

Indexed keywords

DEVELOPING WORLD; DEVELOPMENT PROJECT; FINANCIAL PROVISION; INVESTMENT; LONG-TERM CHANGE; PARTNERSHIP APPROACH; RESEARCH WORK; TRAINING;

AFRICA; CLINICAL TRIAL; FUNDING; GOVERNMENT; HEALTH PROGRAM; HUMAN; INVESTMENT; MEDICAL EDUCATION; MEDICAL EXPERT; MEDICAL PRACTICE; MEDICAL RESEARCH; MULTICENTER STUDY; REVIEW; SCIENTIST;

AFRICA SOUTH OF THE SAHARA; BIOMEDICAL RESEARCH; CLINICAL TRIALS AS TOPIC; DEVELOPING COUNTRIES; EUROPEAN UNION; HUMANS; INTERNATIONAL COOPERATION; LONDON; PROGRAM DEVELOPMENT; ZAMBIA;

EUROPE; SUB-SAHARAN AFRICA;

EID: 77949370595     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2010.02479.x     Document Type: Review

References (45)

1. Andersson N & Marks S (1989) The state, class and the allocation of health resources in southern Africa. Social Science and Medicine 28, 515-530.
2. Anonymous (2004) A new vision for clinical trials in Africa. Promising European funding body is stumbling over the details. PLoSMedicine 1, e71.
3. Anonymous (2005) Europe's science bureaucrats should learn from Gate's success. Lancet 366, 2.
4. Anonymous (2007) Europe's clinical trials partnership programme in peril. Lancet 370, 362.
5. Bosch X (2002) Europe and Africa forge new alliance against poverty-related disease. Lancet 359, 1588.
6. Chintu C & Mwaba P (2000) Striving for global drug availability. Lancet 356 (Suppl.), S5.
7. Chintu C & Mwinga A (1999) An African perspective on the threat of tuberculosis and HIV ? AIDS-can despair be turned to hope? Lancet 353, 997.
8. Chintu C & Zumla A (1993) AIDS case definitions in developing countries. Lancet 342, 1054-1055.
9. Chintu C, Luo C, Bhat G, Raviglione M, DuPont HL & Zumla A (1993a) Cutaneous hypersensitivity reactions due to thiacetazone in Zambian children infected with tuberculosis and the human immunodeficiency virus. Archives of Diseases in Childhood 68, 331-334.
10. Chintu C, Luo C, Bhat G et al. (1993b) Seroprevalence of HIV-1 infection in Zambian children with tuberculosis. Paediatric Infectious Diseases 12, 499-504.
11. Chintu C, Mudenda V, Lucas S et al. (2002) Lung diseases at necropsy in African children dying of respiratory illnesses -a descriptive necropsy study. Lancet 360, 985-990.
12. Chintu C, Bhat GJ, Mulenga V et al. (2004) Co-trimoxazole as prophylaxis against opportunistic infections in HIV- infected Zambian children. A double blind randomized placebo-controlled trial. Lancet 364, 1865-1871.
13. Clarke S (2007) A technocratic imperial state? The colonial office and Scientific Research 1940-1960. Twentieth century British History 18, 453-480. Doi:10.1093 ? tcbh ? hwm17.
14. Costello A & Zumla A (2000) Moving to research partnerships in developing countries. British Medical Journal 30, 827-829.
15. Deacon H (2000) Racism and medical science in South Africa's Cape Colony in the mid- to late nineteenth century. Osiris 15, 190-206.
16. Grange JM, Kapata N, Chanda D, Mwaba P & Zumla A. The biosocial dynamics of tuberculosis. Tropical Medicine and International Health 2009, 14 (2), 124-130. Epub 2009 Jan 15.
17. Kasolo F, Lshimpi K, Chintu C et al. (2002) Identification of Pneumocystis carinii DNA by PCR in necropsy lung tissue samples from children dying of respiratory illnesses. Journal of Pediatrics 140, 367-369.
18. Kitua AY, Corrah T, Herbst K et al. (2009) Strengthening capacity, collaboration and quality of clinical research in Africa: EDCTP Networks of Excellence. Tanzanian Journal of Health Research 11, 51-54.
19. Lishimpi K, Chintu C, Lucas S et al. (2001) Necropsies in African children: consent dilemmas for patients and guardians. Archives of Diseases of Childhood 84, 463-467.
20. Lishimpi K, Kasolo F, Chintu C et al. (2002) Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses. AIDS 16, 932-934.
21. Luo C, Bhat G, Chintu C et al. (1994) Tuberculosis and the human immunodeficiency virus infection in Zambian children: changing seroprevalence and evaluation of a thiacetazone-free regimen. Tubercle and Lung Disease 75, 110-115.
22. Mandalakas AM & Detjen A (2009) Tuberculosis-a comprehensive clinical reference. An invaluable resource in the fight against tuberculosis. Lancet 374, 1959-1960.
23. Matee MI, Manyondo C, Ndumbe PM et al. (2009) European and Developing Country Clinical Trials Partnership (EDCTP): the path towards a true partnership. BMC Public Health 9, e249.
24. Mathewson J, DuPont HL, Luo NP et al. (1994) Intestinal secretory IgA immune response against human immunodeficiency virus among infected patients with acute and chronic diarrhea. Journal of Infectious Diseases 169, 614-617.
25. Mathewson J, Zumla A, Jiang Z et al. (1995) HEp-2 cell adherent Escherichia coli in patients with HIV-associated diarrhoea. Journal of Infectious Diseases 171, 1636-1639.
26. Medaglini D & Hoeveler A (2003) The European research effort for HIV ? AIDS, malaria and tuberculosis. Vaccine 21(Suppl. 2), S116-S120.
27. Mgone C (2008) The emerging shape of a global HIV research agenda: how partnerships between northern and southern researchers are addressing questions relevant to both. Curr Opin HIV AIDS 3, 521-525.
28. Mgone CS & Salami W (2009) EDCTP: a genuine north-south partnership. Tropical Medicine and International Health 14, 1327-1328.
29. Mwaba P, Cassol S, Nunn A et al. (2003a) Whole blood versus plasma spots for measurement of HIV-1 viral load in HIVinfected African patients. Lancet 362, 2067-2068.
30. Mwaba P, Cassol S & Pilon R (2003b) Use of dried whole blood spots to measure CD4 + lymphocyte counts in HIV-1-infected patients. Lancet 362, 1459-1460.
31. Mwinga A, Nunn A, Ngwira B et al. (2002) Mycobacterium vaccae (SRL172) Immunotherapy as an adjunct to standard anti-tuberculosis therapy in HIV-infected Zambian and Malawian Adults with Pulmonary Tuberculosis - a randomised placebo-controlled clinical trial. Lancet 360, 1050-1055.
32. Nabarro D (1998) International Health and Beyond. Nature Medicine 4, 762-761.
33. Nature News (2009a) Funding boost for African science. Wellcome trust grants £30 million to help build research capacity. http://www.nature.com/ news/2009/090701/full/news.2009.607.html.
34. Nature News (2009b) Wellcome trust makes it personal in funding revamp. People not projects are the focus of longer-term grants. http://www.nature.com/ news/2009/091111/full/462145a.html.
35. Nunn A, Mwaba P, Mwinga A et al. (2008) Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial. British Medical Journal 337, 257.
36. Olliaro P & Smith PG (2002) The European and developing countries clinical trials partnership. Journal of HIV Therapy 9, 53-56.
37. Onyebujoh P, Rodriguez W & Mwaba P (2006) Priorities in tuberculosis research. Lancet 367, 940-942.
38. Oshitani H, Kasolo FC, Mpabalwani M et al. (1994) Association of Rotavirus and HIV infection in hospitalised children with acute diarrhoea, Lusaka, Zambia. Journal of Infectious Diseases 169, 897-900.
39. Pletschette M & Nair S (2004) Tuberculosis research: an end to neglect and negligence. Tropical Medicine and International Health 9, 817.
40. Walgate R (2002) Europe finds US$200million to support African clinical trials. Bull WHO 80, 10-843.
41. Welcome Trust (2009) Research capacity strengthening in Africa African Institutions Initiative http://www.wellcome.ac.uk/Funding/Biomedical-science/ Grants/Other-initiatives/ WTD028338.htm.
42. Whitworth JAG, Kowro G, Snewin V, Tanner M, Walport M & Sewankambo N (2008) Strengthening capacity for health research in Africa. Lancet 372, 1590-1593.
43. Zumla A & Chintu C (1994) Tuberculosis and HIV infection. Lancet 343, 851-852.
44. Zumla A, Mwaba P, Squire SB & Grange JM (1999) The tuberculosis pandemic-which way now? Journal of Infection 38, 74-79.
45. Zumla A, Mwaba P, Huggett J, Kapata N, Chanda D & Grange J (2009) Reflections on the white plague. Lancet Infectious Diseases 3, 197-202.