Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: Performance of three pharmacokinetic-dynamic models

British Journal of Anaesthesia

Volumn 104, Issue 4, 2010, Pages 452-458

  Coppens, M ^a   Van Limmen, J G M ^a   Schnider, T ^b   Wyler, B ^c   Bonte, S ^a   Dewaele, F ^a   Struys, M M R F ^a,d   Vereecke, H E M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Drug delivery, computerized; Model, pharmacodynamic; Model, pharmacokinetic; Monitoring, depth of anaesthesia; Pharmacology, propofol

Indexed keywords

HYPNOTIC AGENT; PROPOFOL;

ADULT; AGED; ALGORITHM; ANESTHESIA; ANESTHESIA INDUCTION; ARTICLE; BISPECTRAL INDEX; CONSCIOUSNESS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; EFFECT SIZE; EQUILIBRIUM CONSTANT; FEMALE; HUMAN; HYPNOSIS; INFUSION; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; PHARMACODYNAMICS; PHARMACOLOGICAL PROCEDURES; PRIORITY JOURNAL; TARGET CONTROLLED INFUSION; TIME; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 77949356177     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq028     Document Type: Article

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