메뉴 건너뛰기




Volumn 5, Issue 1, 2010, Pages 37-46

Progesterone treatment for brain injury: An update

Author keywords

Functional recovery; Neurosteroids; Progesterone; Traumatic brain injury

Indexed keywords

CALCITRIOL; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; MEMBRANE PROGESTERONE RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PLACEBO; PROGESTERONE; PROGESTERONE RECEPTOR; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VITAMIN D;

EID: 77949355099     PISSN: 14796708     EISSN: None     Source Type: Journal    
DOI: 10.2217/fnl.09.72     Document Type: Review
Times cited : (4)

References (79)
  • 1
    • 39049137643 scopus 로고    scopus 로고
    • Progesterone in the experimental treatment of central and peripheral nervous system injuries
    • Stein DG: Progesterone in the experimental treatment of central and peripheral nervous system injuries. Future Neurol. 1(4), 429-438 (2006).
    • (2006) Future Neurol , vol.1 , Issue.4 , pp. 429-438
    • Stein, D.G.1
  • 2
    • 33947165175 scopus 로고    scopus 로고
    • ProTECT: A randomized clinical trial of progesterone for acute traumatic brain injury
    • Wright DW, Kellermann AL, Hertzberg VS et al.: ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann. Emerg. Med. 49, 391-402 (2007).
    • (2007) Ann. Emerg. Med , vol.49 , pp. 391-402
    • Wright, D.W.1    Kellermann, A.L.2    Hertzberg, V.S.3
  • 3
    • 43249131666 scopus 로고    scopus 로고
    • Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: A randomized controlled trial
    • Xiao G, Wei J, Yan W, Wang W, Lu Z: Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit. Care 12, R61 (2008).
    • (2008) Crit. Care , vol.12
    • Xiao, G.1    Wei, J.2    Yan, W.3    Wang, W.4    Lu, Z.5
  • 4
    • 0347593988 scopus 로고    scopus 로고
    • Clinical trials in traumatic brain injury: Lessons for the future
    • Doppenberg EM, Choi SC, Bullock R: Clinical trials in traumatic brain injury: lessons for the future. J. Neurosurg. Anesthesiol. 16, 87-94 (2004).
    • (2004) J. Neurosurg. Anesthesiol , vol.16 , pp. 87-94
    • Doppenberg, E.M.1    Choi, S.C.2    Bullock, R.3
  • 6
    • 34548610385 scopus 로고    scopus 로고
    • Progesterone: Therapeutic opportunities for neuroprotection and myelin repair
    • Schumacher M, Guennoun R, Stein DG, De Nicola AF: Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacol. Ther. 116, 77-107 (2007).
    • (2007) Pharmacol. Ther , vol.116 , pp. 77-107
    • Schumacher, M.1    Guennoun, R.2    Stein, D.G.3    De Nicola, A.F.4
  • 7
    • 38449090571 scopus 로고    scopus 로고
    • Estrogens and progesterone as neuroprotectants: What animal models teach us
    • Singh M, Sumien N, Kyser C, Simpkins JW: Estrogens and progesterone as neuroprotectants: what animal models teach us. Front. Biosci. 13, 1083-1089 (2008).
    • (2008) Front. Biosci , vol.13 , pp. 1083-1089
    • Singh, M.1    Sumien, N.2    Kyser, C.3    Simpkins, J.W.4
  • 8
    • 84884762146 scopus 로고    scopus 로고
    • Effects of sex steroids on damaged neural systems
    • 2nd Edition. Pfaff DW, Arnold AP, Etgen AM et al, Eds, Elsevier, Oxford, UK
    • Stein DG, Hurn PD: Effects of sex steroids on damaged neural systems. In: Hormones, Brain and Behavior. 2nd Edition. Pfaff DW, Arnold AP, Etgen AM et al. (Eds). Elsevier, Oxford, UK, 2223-2258 (2009).
    • (2009) Hormones, Brain and Behavior , pp. 2223-2258
    • Stein, D.G.1    Hurn, P.D.2
  • 9
    • 40749153470 scopus 로고    scopus 로고
    • Progesterone exerts neuroprotective effects after brain injury
    • Stein DG: Progesterone exerts neuroprotective effects after brain injury. Brain Res. Rev. 57, 386-397 (2008).
    • (2008) Brain Res. Rev , vol.57 , pp. 386-397
    • Stein, D.G.1
  • 10
    • 38349052883 scopus 로고    scopus 로고
    • Does progesterone have neuroprotective properties?
    • Stein DG, Wright DW, Kellermann AL: Does progesterone have neuroprotective properties? Ann. Emerg. Med. 51, 164-172 (2008).
    • (2008) Ann. Emerg. Med , vol.51 , pp. 164-172
    • Stein, D.G.1    Wright, D.W.2    Kellermann, A.L.3
  • 11
    • 0023629050 scopus 로고
    • Hormonal state affects recovery from frontal cortex lesions in adult female rats
    • Attella MJ, Nattinville A, Stein DG: Hormonal state affects recovery from frontal cortex lesions in adult female rats. Behav. Neural Biol. 48, 352-367 (1987).
    • (1987) Behav. Neural Biol , vol.48 , pp. 352-367
    • Attella, M.J.1    Nattinville, A.2    Stein, D.G.3
  • 12
    • 38849190685 scopus 로고    scopus 로고
    • Progesterone for the treatment of experimental brain injury; a systematic review
    • Gibson CL, Gray LJ, Bath PM, Murphy SP: Progesterone for the treatment of experimental brain injury; a systematic review. Brain 131, 318-328 (2008).
    • (2008) Brain , vol.131 , pp. 318-328
    • Gibson, C.L.1    Gray, L.J.2    Bath, P.M.3    Murphy, S.P.4
  • 13
    • 52449092324 scopus 로고    scopus 로고
    • Progesterone in traumatic brain injury: Time to move on to Phase III trials
    • Vandromme M, Melton SM, Kerby JD: Progesterone in traumatic brain injury: time to move on to Phase III trials. Crit. Care 12, 153 (2008).
    • (2008) Crit. Care , vol.12 , pp. 153
    • Vandromme, M.1    Melton, S.M.2    Kerby, J.D.3
  • 15
    • 47149112183 scopus 로고    scopus 로고
    • Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage
    • Cai W, Zhu Y, Furuya K et al.: Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage. Neuropharmacology 55, 127-138 (2008).
    • (2008) Neuropharmacology , vol.55 , pp. 127-138
    • Cai, W.1    Zhu, Y.2    Furuya, K.3
  • 16
    • 70350455733 scopus 로고    scopus 로고
    • Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells
    • Behera MA, Dai Q, Garde R et al.: Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. Am. J. Physiol. Endocrinol. Metab. 297, E1089-E1096 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.297
    • Behera, M.A.1    Dai, Q.2    Garde, R.3
  • 17
    • 34548554170 scopus 로고    scopus 로고
    • Progesterone prevents traumatic brain injury-induced intestinal nuclear factor-κβ activation and proinflammatory cytokines expression in male rats
    • Chen G, Shi J, Ding Y, Yin H, Hang C: Progesterone prevents traumatic brain injury-induced intestinal nuclear factor-κβ activation and proinflammatory cytokines expression in male rats. Med. Inflamm. 2007, 93431 (2007).
    • (2007) Med. Inflamm , vol.2007 , pp. 93431
    • Chen, G.1    Shi, J.2    Ding, Y.3    Yin, H.4    Hang, C.5
  • 18
    • 65649146102 scopus 로고    scopus 로고
    • Exogenous progesterone: A potential therapeutic candidate in CNS injury and neurodegeneration
    • Hu Z, Li Y, Fang M, Wai MS, Yew DT: Exogenous progesterone: a potential therapeutic candidate in CNS injury and neurodegeneration. Curr. Med. Chem. 16, 1418-1425 (2009).
    • (2009) Curr. Med. Chem , vol.16 , pp. 1418-1425
    • Hu, Z.1    Li, Y.2    Fang, M.3    Wai, M.S.4    Yew, D.T.5
  • 19
    • 34548089961 scopus 로고    scopus 로고
    • Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion
    • Sayeed I, Wali B, Stein DG: Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor. Neurol. Neurosci. 25, 151-159 (2007).
    • (2007) Restor. Neurol. Neurosci , vol.25 , pp. 151-159
    • Sayeed, I.1    Wali, B.2    Stein, D.G.3
  • 20
    • 33644520587 scopus 로고    scopus 로고
    • Signaling mechanisms in progesterone-neurotransmitter interactions
    • Mani SK: Signaling mechanisms in progesterone-neurotransmitter interactions. Neuroscience 138, 773-781 (2006).
    • (2006) Neuroscience , vol.138 , pp. 773-781
    • Mani, S.K.1
  • 21
    • 63549120450 scopus 로고    scopus 로고
    • Steroid hormone action in the brain: Cross-talk between signalling pathways
    • Mani SK, Portillo W, Reyna A: Steroid hormone action in the brain: cross-talk between signalling pathways. J. Neuroendocrinol. 21, 243-247 (2009).
    • (2009) J. Neuroendocrinol , vol.21 , pp. 243-247
    • Mani, S.K.1    Portillo, W.2    Reyna, A.3
  • 22
    • 0344393081 scopus 로고    scopus 로고
    • Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord
    • Labombarda F, Gonzalez SL, Deniselle MC et al.: Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord. J. Neurochem. 87, 902-913 (2003).
    • (2003) J. Neurochem , vol.87 , pp. 902-913
    • Labombarda, F.1    Gonzalez, S.L.2    Deniselle, M.C.3
  • 23
    • 33645835905 scopus 로고    scopus 로고
    • Patch clamp reveals powerful blockade of the mitochondrial permeability transition pore by the D2-receptor agonist pramipexole
    • Sayeed I, Parvez S, Winkler-Stuck K et al.: Patch clamp reveals powerful blockade of the mitochondrial permeability transition pore by the D2-receptor agonist pramipexole. FASEB J. 20, 556-558 (2006).
    • (2006) FASEB J , vol.20 , pp. 556-558
    • Sayeed, I.1    Parvez, S.2    Winkler-Stuck, K.3
  • 24
    • 73349102538 scopus 로고    scopus 로고
    • Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: A patch clamp study
    • Ziegler E, Bodusch M, Song Y et al.: Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study. Naunyn Schmiedebergs Arch. Pharmacol. 380, 277-291 (2009).
    • (2009) Naunyn Schmiedebergs Arch. Pharmacol , vol.380 , pp. 277-291
    • Ziegler, E.1    Bodusch, M.2    Song, Y.3
  • 25
    • 12544255204 scopus 로고    scopus 로고
    • The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats
    • Djebaili M, Guo Q, Pettus EH, Hoffman SW, Stein DG: The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. J. Neurotrauma 22, 106-118 (2005).
    • (2005) J. Neurotrauma , vol.22 , pp. 106-118
    • Djebaili, M.1    Guo, Q.2    Pettus, E.H.3    Hoffman, S.W.4    Stein, D.G.5
  • 26
    • 20544465189 scopus 로고    scopus 로고
    • Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats
    • Yao XL, Liu J, Lee E, Ling GS, McCabe JT: Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats. J. Neurotrauma 22, 656-668 (2005).
    • (2005) J. Neurotrauma , vol.22 , pp. 656-668
    • Yao, X.L.1    Liu, J.2    Lee, E.3    Ling, G.S.4    McCabe, J.T.5
  • 27
    • 33644560650 scopus 로고    scopus 로고
    • Estrogen therapy: Does it help or hurt the adult and aging brain? Insights derived from animal models
    • Wise PM: Estrogen therapy: does it help or hurt the adult and aging brain? Insights derived from animal models. Neuroscience 138, 831-835 (2006).
    • (2006) Neuroscience , vol.138 , pp. 831-835
    • Wise, P.M.1
  • 28
    • 0037202033 scopus 로고    scopus 로고
    • Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain
    • Guerra-Araiza C, Coyoy-Salgado A, Camacho-Arroyo I: Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain. Brain Res. Bull. 59, 105-109 (2002).
    • (2002) Brain Res. Bull , vol.59 , pp. 105-109
    • Guerra-Araiza, C.1    Coyoy-Salgado, A.2    Camacho-Arroyo, I.3
  • 29
    • 67449111218 scopus 로고    scopus 로고
    • Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures
    • You JM, Yun SJ, Nam KN et al.: Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures. Can. J. Physiol. Pharmacol. 87, 440-447 (2009).
    • (2009) Can. J. Physiol. Pharmacol , vol.87 , pp. 440-447
    • You, J.M.1    Yun, S.J.2    Nam, K.N.3
  • 30
    • 29144480051 scopus 로고    scopus 로고
    • Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats
    • Robertson CL, Puskar A, Hoffman GE et al.: Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats. Exp. Neurol. 197, 235-243 (2006).
    • (2006) Exp. Neurol , vol.197 , pp. 235-243
    • Robertson, C.L.1    Puskar, A.2    Hoffman, G.E.3
  • 31
    • 49249114754 scopus 로고    scopus 로고
    • Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury
    • Roglio I, Bianchi R, Gotti S et al.: Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Neuroscience 155, 673-685 (2008).
    • (2008) Neuroscience , vol.155 , pp. 673-685
    • Roglio, I.1    Bianchi, R.2    Gotti, S.3
  • 32
    • 48349143179 scopus 로고    scopus 로고
    • Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis
    • Garay L, Gonzalez Deniselle MC, Gierman L et al.: Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis. Neuroimmunomodulation 15, 76-83 (2008).
    • (2008) Neuroimmunomodulation , vol.15 , pp. 76-83
    • Garay, L.1    Gonzalez Deniselle, M.C.2    Gierman, L.3
  • 33
    • 67349166912 scopus 로고    scopus 로고
    • Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration
    • De Nicola AF, Labombarda F, Deniselle MC et al.: Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration. Front. Neuroendocrinol. 30, 173-187 (2009).
    • (2009) Front. Neuroendocrinol , vol.30 , pp. 173-187
    • De Nicola, A.F.1    Labombarda, F.2    Deniselle, M.C.3
  • 34
    • 34247641659 scopus 로고    scopus 로고
    • A receptor-mediated transmission in the hypothalamus: Effects on reproductive function
    • A receptor-mediated transmission in the hypothalamus: effects on reproductive function. Neuropharmacology 52, 1439-1453 (2007).
    • (2007) Neuropharmacology , vol.52 , pp. 1439-1453
    • Henderson, L.P.1
  • 35
    • 37049023663 scopus 로고    scopus 로고
    • Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury
    • Pan DS, Liu WG, Yang XF, Cao F: Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury. Biomed. Environ. Sci. 20, 432-438 (2007).
    • (2007) Biomed. Environ. Sci , vol.20 , pp. 432-438
    • Pan, D.S.1    Liu, W.G.2    Yang, X.F.3    Cao, F.4
  • 36
    • 40049104041 scopus 로고    scopus 로고
    • Progesterone administration modulates TLRs/NF-κβ signaling pathway in rat brain after cortical contusion
    • Chen G, Shi J, Jin W et al.: Progesterone administration modulates TLRs/NF-κβ signaling pathway in rat brain after cortical contusion. Ann. Clin. Lab. Sci. 38, 65-74 (2008).
    • (2008) Ann. Clin. Lab. Sci , vol.38 , pp. 65-74
    • Chen, G.1    Shi, J.2    Jin, W.3
  • 37
    • 43049148389 scopus 로고    scopus 로고
    • Effects of progesterone on intestinal inflammatory response, mucosa structure alterations, and apoptosis following traumatic brain injury in male rats
    • Chen G, Shi JX, Qi M, Wang HX, Hang CH: Effects of progesterone on intestinal inflammatory response, mucosa structure alterations, and apoptosis following traumatic brain injury in male rats. J. Surg. Res. 147, 92-98 (2008).
    • (2008) J. Surg. Res , vol.147 , pp. 92-98
    • Chen, G.1    Shi, J.X.2    Qi, M.3    Wang, H.X.4    Hang, C.H.5
  • 38
    • 0032724682 scopus 로고    scopus 로고
    • Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat
    • Chen J, Chopp M, Li Y: Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J. Neurol. Sci. 171, 24-30 (1999).
    • (1999) J. Neurol. Sci , vol.171 , pp. 24-30
    • Chen, J.1    Chopp, M.2    Li, Y.3
  • 39
    • 16344388275 scopus 로고    scopus 로고
    • A receptors in the hippocampus may mediate some antiseizure effects of progestins
    • A receptors in the hippocampus may mediate some antiseizure effects of progestins. Epilepsy Behav. 6, 320-327 (2005).
    • (2005) Epilepsy Behav , vol.6 , pp. 320-327
    • Rhodes, M.E.1    Frye, C.A.2
  • 40
    • 34547861677 scopus 로고    scopus 로고
    • Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain
    • Quadros PS, Pfau JL, Wagner CK: Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain. J. Comp. Neurol. 504, 42-56 (2007).
    • (2007) J. Comp. Neurol , vol.504 , pp. 42-56
    • Quadros, P.S.1    Pfau, J.L.2    Wagner, C.K.3
  • 41
    • 16844364267 scopus 로고    scopus 로고
    • Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats
    • Moorthy K, Sharma D, Basir SF, Baquer NZ: Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats. Exp. Gerontol. 40, 295-302 (2005).
    • (2005) Exp. Gerontol , vol.40 , pp. 295-302
    • Moorthy, K.1    Sharma, D.2    Basir, S.F.3    Baquer, N.Z.4
  • 42
    • 34848824375 scopus 로고    scopus 로고
    • Progesterone improves acute recovery after traumatic brain injury in the aged rat
    • Cutler SM, Cekic M, Miller DM et al.: Progesterone improves acute recovery after traumatic brain injury in the aged rat. J. Neurotrauma 24, 1475-1486 (2007).
    • (2007) J. Neurotrauma , vol.24 , pp. 1475-1486
    • Cutler, S.M.1    Cekic, M.2    Miller, D.M.3
  • 43
    • 33645747664 scopus 로고    scopus 로고
    • Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats
    • Guo Q, Sayeed I, Baronne LM et al.: Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats. Exp. Neurol. 198, 469-478 (2006).
    • (2006) Exp. Neurol , vol.198 , pp. 469-478
    • Guo, Q.1    Sayeed, I.2    Baronne, L.M.3
  • 44
    • 33750726032 scopus 로고    scopus 로고
    • The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury
    • Vanlandingham JW, Cutler SM, Virmani S et al.: The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury. Neuropharmacology 51, 1078-1085 (2006).
    • (2006) Neuropharmacology , vol.51 , pp. 1078-1085
    • Vanlandingham, J.W.1    Cutler, S.M.2    Virmani, S.3
  • 46
    • 11144284666 scopus 로고    scopus 로고
    • Anxiolytic activity of progesterone in progesterone receptor knockout mice
    • Reddy DS, O'Malley BW, Rogawski MA: Anxiolytic activity of progesterone in progesterone receptor knockout mice. Neuropharmacology 48, 14-24 (2005).
    • (2005) Neuropharmacology , vol.48 , pp. 14-24
    • Reddy, D.S.1    O'Malley, B.W.2    Rogawski, M.A.3
  • 47
    • 12944299270 scopus 로고    scopus 로고
    • Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice
    • Reddy DS, Apanites LA: Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice. Brain Res. 1033, 96-101 (2005).
    • (2005) Brain Res , vol.1033 , pp. 96-101
    • Reddy, D.S.1    Apanites, L.A.2
  • 48
    • 70249149974 scopus 로고    scopus 로고
    • Neuroactive steroid regulation of neurotransmitter release in the CNS: Action, mechanism and possible significance
    • Zheng P: Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Prog. Neurobiol. 89(2), 134-152 (2009).
    • (2009) Prog. Neurobiol , vol.89 , Issue.2 , pp. 134-152
    • Zheng, P.1
  • 50
    • 63649135796 scopus 로고    scopus 로고
    • ent-Steroids: Novel tools for studies of signaling pathways
    • Covey DF: ent-Steroids: novel tools for studies of signaling pathways. Steroids 74, 577-585 (2009).
    • (2009) Steroids , vol.74 , pp. 577-585
    • Covey, D.F.1
  • 51
    • 49249122123 scopus 로고    scopus 로고
    • Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors
    • Jones LA, Anthony JP, Henriquez FL et al.: Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors. Immunology 125, 59-69 (2008).
    • (2008) Immunology , vol.125 , pp. 59-69
    • Jones, L.A.1    Anthony, J.P.2    Henriquez, F.L.3
  • 52
    • 61449169005 scopus 로고    scopus 로고
    • Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons
    • Hwang JY, Duncan RS, Madry C, Singh M, Koulen P: Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons. Cell Calcium 45, 233-242 (2009).
    • (2009) Cell Calcium , vol.45 , pp. 233-242
    • Hwang, J.Y.1    Duncan, R.S.2    Madry, C.3    Singh, M.4    Koulen, P.5
  • 53
    • 47649112095 scopus 로고    scopus 로고
    • Neurosteroids are excitatory in supraoptic neurons but inhibitory in the peripheral nervous system: It is all about oxytocin and progesterone receptors
    • Viero C, Dayanithi G: Neurosteroids are excitatory in supraoptic neurons but inhibitory in the peripheral nervous system: it is all about oxytocin and progesterone receptors. Prog. Brain Res. 170, 177-192 (2008).
    • (2008) Prog. Brain Res , vol.170 , pp. 177-192
    • Viero, C.1    Dayanithi, G.2
  • 54
    • 66449134231 scopus 로고    scopus 로고
    • Expression, localization and possible actions of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum: A new insight into the biosynthesis, metabolism and multiple actions of progesterone as a neurosteroid
    • Sakamoto H, Ukena K, Kawata M, Tsutsui K: Expression, localization and possible actions of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum: a new insight into the biosynthesis, metabolism and multiple actions of progesterone as a neurosteroid. Cerebellum 7, 18-25 (2008).
    • (2008) Cerebellum , vol.7 , pp. 18-25
    • Sakamoto, H.1    Ukena, K.2    Kawata, M.3    Tsutsui, K.4
  • 55
    • 40749147175 scopus 로고    scopus 로고
    • The membrane-associated progesteronebinding protein 25-Dx: Expression, cellular localization and up-regulation after brain and spinal cord injuries
    • Guennoun R, Meffre D, Labombarda F et al.: The membrane-associated progesteronebinding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries. Brain Res. Rev. 57, 493-505 (2008).
    • (2008) Brain Res. Rev , vol.57 , pp. 493-505
    • Guennoun, R.1    Meffre, D.2    Labombarda, F.3
  • 56
    • 53049107540 scopus 로고    scopus 로고
    • Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal rats
    • Quadros PS, Schlueter LJ, Wagner CK: Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal rats. Dev. Neurobiol. 68, 1378-1390 (2008).
    • (2008) Dev. Neurobiol , vol.68 , pp. 1378-1390
    • Quadros, P.S.1    Schlueter, L.J.2    Wagner, C.K.3
  • 58
    • 44249128152 scopus 로고    scopus 로고
    • Progestin receptor subtypes in the brain: The known and the unknown
    • Mani S: Progestin receptor subtypes in the brain: the known and the unknown. Endocrinology 149, 2750-2756 (2008).
    • (2008) Endocrinology , vol.149 , pp. 2750-2756
    • Mani, S.1
  • 59
    • 2442645134 scopus 로고    scopus 로고
    • Moderate and severe traumatic brain injury: Epidemiologic, imaging and neuropathologic perspectives
    • McArthur DL, Chute DJ, Villablanca JP: Moderate and severe traumatic brain injury: epidemiologic, imaging and neuropathologic perspectives. Brain Pathol. 14, 185-194 (2004).
    • (2004) Brain Pathol , vol.14 , pp. 185-194
    • McArthur, D.L.1    Chute, D.J.2    Villablanca, J.P.3
  • 60
    • 39149109142 scopus 로고    scopus 로고
    • Detrimental effects of aging on outcome from traumatic brain injury: A behavioral, magnetic resonance imaging, and histological study in mice
    • Onyszchuk G, He YY, Berman NE, Brooks WM: Detrimental effects of aging on outcome from traumatic brain injury: a behavioral, magnetic resonance imaging, and histological study in mice. J. Neurotrauma 25, 153-171 (2008).
    • (2008) J. Neurotrauma , vol.25 , pp. 153-171
    • Onyszchuk, G.1    He, Y.Y.2    Berman, N.E.3    Brooks, W.M.4
  • 61
    • 42249090551 scopus 로고    scopus 로고
    • Vitamin D deficiency: A worldwide problem with health consequences
    • Holick MF, Chen TC: Vitamin D deficiency: a worldwide problem with health consequences. Am. J. Clin. Nutr. 87, S1080-S1086 (2008).
    • (2008) Am. J. Clin. Nutr , vol.87
    • Holick, M.F.1    Chen, T.C.2
  • 62
    • 33744923159 scopus 로고    scopus 로고
    • Epidemiology of disease risks in relation to vitamin D insufficiency
    • Grant WB: Epidemiology of disease risks in relation to vitamin D insufficiency. Prog. Biophys. Mol. Biol. 92, 65-79 (2006).
    • (2006) Prog. Biophys. Mol. Biol , vol.92 , pp. 65-79
    • Grant, W.B.1
  • 63
    • 33847162739 scopus 로고    scopus 로고
    • Hypovitaminosis D in internal medicine inpatients
    • Corino A, D'Amelio P, Gancia R et al.: Hypovitaminosis D in internal medicine inpatients. Calcif. Tissue Int. 80, 76-80 (2007).
    • (2007) Calcif. Tissue Int , vol.80 , pp. 76-80
    • Corino, A.1    D'Amelio, P.2    Gancia, R.3
  • 64
    • 34447105503 scopus 로고    scopus 로고
    • Vitamin D deficiency in general medical inpatients in summer and winter
    • Chatfield SM, Brand C, Ebeling PR, Russell DM: Vitamin D deficiency in general medical inpatients in summer and winter. Intern. Med. J. 37, 377-382 (2007).
    • (2007) Intern. Med. J , vol.37 , pp. 377-382
    • Chatfield, S.M.1    Brand, C.2    Ebeling, P.R.3    Russell, D.M.4
  • 65
    • 79954598164 scopus 로고    scopus 로고
    • Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats
    • DOI: 10.1016/j.neurobiolaging.2009.04.017 , Epub ahead of print
    • Cekic M, Cutler SM, Vanlandingham JW, Stein DG: Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats. Neurobiol. Aging DOI: 10.1016/j.neurobiolaging.2009.04.017 (2009) (Epub ahead of print).
    • (2009) Neurobiol. Aging
    • Cekic, M.1    Cutler, S.M.2    Vanlandingham, J.W.3    Stein, D.G.4
  • 66
    • 36749052256 scopus 로고    scopus 로고
    • Assessment of the clinical course with inflammatory parameters
    • Pape HC, Tsukamoto T, Kobbe P et al.: Assessment of the clinical course with inflammatory parameters. Injury 38, 1358-1364 (2007).
    • (2007) Injury , vol.38 , pp. 1358-1364
    • Pape, H.C.1    Tsukamoto, T.2    Kobbe, P.3
  • 67
    • 67849135779 scopus 로고    scopus 로고
    • Combination therapies for traumatic brain injury: Prospective considerations
    • Margulies S, Hicks R: Combination therapies for traumatic brain injury: prospective considerations. J. Neurotrauma 26, 925-939 (2009).
    • (2009) J. Neurotrauma , vol.26 , pp. 925-939
    • Margulies, S.1    Hicks, R.2
  • 68
    • 67349222799 scopus 로고    scopus 로고
    • Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease
    • Cekic M, Sayeed I, Stein DG: Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease. Front. Neuroendocrinol. 30, 158-172 (2009).
    • (2009) Front. Neuroendocrinol , vol.30 , pp. 158-172
    • Cekic, M.1    Sayeed, I.2    Stein, D.G.3
  • 69
    • 70149092981 scopus 로고    scopus 로고
    • Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone
    • Atif F, Sayeed I, Ishrat T, Stein DG: Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone. Mol. Med. 15(9-10), 328-336 (2009).
    • (2009) Mol. Med , vol.15 , Issue.9-10 , pp. 328-336
    • Atif, F.1    Sayeed, I.2    Ishrat, T.3    Stein, D.G.4
  • 70
    • 0142195893 scopus 로고    scopus 로고
    • Behavioral effects and anatomic correlates after brain injury: A progesterone dose-response study
    • Goss CW, Hoffman SW, Stein DG: Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study. Pharmacol. Biochem. Behav. 76, 231-242 (2003).
    • (2003) Pharmacol. Biochem. Behav , vol.76 , pp. 231-242
    • Goss, C.W.1    Hoffman, S.W.2    Stein, D.G.3
  • 71
    • 68849103260 scopus 로고    scopus 로고
    • The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling
    • Mizwicki MT, Norman AW: The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling. Sci. Signal. 2(75), re4 (2009).
    • (2009) Sci. Signal , vol.2 , Issue.75
    • Mizwicki, M.T.1    Norman, A.W.2
  • 72
    • 70350440282 scopus 로고    scopus 로고
    • Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter
    • Eloranta JJ, Hiller C, Hausler S, Stieger B, Kullak-Ublick GA: Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter. Mol Pharmacol. 76(5), 1062-1071 (2009).
    • (2009) Mol Pharmacol , vol.76 , Issue.5 , pp. 1062-1071
    • Eloranta, J.J.1    Hiller, C.2    Hausler, S.3    Stieger, B.4    Kullak-Ublick, G.A.5
  • 73
    • 71449103001 scopus 로고    scopus 로고
    • Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases
    • DOI: 10.1016/j.psyneuen.2009.05.023 , Epub ahead of print
    • Fernandes de Abreu DA, Eyles D, Féron F: Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology DOI: 10.1016/j.psyneuen.2009.05.023 (2009) (Epub ahead of print).
    • (2009) Psychoneuroendocrinology
    • Fernandes de Abreu, D.A.1    Eyles, D.2    Féron, F.3
  • 74
    • 52649155487 scopus 로고    scopus 로고
    • Vitamin D's role in cell proliferation and differentiation
    • Samuel S, Sitrin MD: Vitamin D's role in cell proliferation and differentiation. Nutr. Rev. 66, S116-S124 (2008).
    • (2008) Nutr. Rev , vol.66
    • Samuel, S.1    Sitrin, M.D.2
  • 75
    • 57449111301 scopus 로고    scopus 로고
    • 1,25-Dihydroxy vitamin D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60-activated matrix vesicle matrix metalloproteinases
    • Boyan BD, Schwartz Z: 1,25-Dihydroxy vitamin D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60-activated matrix vesicle matrix metalloproteinases. Cells Tissues Organs 189, 70-74 (2009).
    • (2009) Cells Tissues Organs , vol.189 , pp. 70-74
    • Boyan, B.D.1    Schwartz, Z.2
  • 76
    • 37249080181 scopus 로고    scopus 로고
    • Vitamin D: Molecular mechanism of action
    • Christakos S, Dhawan P, Benn B et al.: Vitamin D: molecular mechanism of action. Ann. NY Acad. Sci. 1116, 340-348 (2007).
    • (2007) Ann. NY Acad. Sci , vol.1116 , pp. 340-348
    • Christakos, S.1    Dhawan, P.2    Benn, B.3
  • 78
    • 84868290204 scopus 로고    scopus 로고
    • is traumatic brain injury, Accessed September 2009
    • Centers for Disease Control: What is traumatic brain injury. www.cdc.gov/ncipc/tbi/TBI.htm (Accessed September 2009)
    • Centers for Disease Control: What
  • 79
    • 77949389738 scopus 로고    scopus 로고
    • ClinicalTrials.gov http://clinicaltrials.gov/ct2/show/NCT00822900?term= progesterone,+TBI&rank=1
    • ClinicalTrials.gov http://clinicaltrials.gov/ct2/show/NCT00822900?term= progesterone,+TBI&rank=1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.