The use of sensory nerve stimulation and compression bandaging to improve sensory nerve function and healing of chronic venous leg ulcers

Current Aging Science

Volumn 2, Issue 1, 2009, Pages 72-80

  Ogrin, Rajna ^a   Darzins, Peteris ^b   Khalil, Zeinab ^a,c,d  

^a HEIDELBERG REPATRIATION HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF SHARJAH   (United Arab Emirates)

Author keywords

Four layer compression bandaging and venous ulcers; Sensory nerve stimulation

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPRESSION BANDAGE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPPLER FLOWMETRY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTERMETHOD COMPARISON; LEG ULCER; MALE; NERVE STIMULATION; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENESCENCE; SENSORY NERVE; TREATMENT OUTCOME; WOUND HEALING; AGED; BANDAGE; BLOOD FLOW; CHRONIC DISEASE; COMPRESSION GARMENT; ELECTROSTIMULATION THERAPY; LEG; METHODOLOGY; MICROCIRCULATION; NONMYELINATED NERVE; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY RECEPTOR; VASCULARIZATION;

AGED; BANDAGES; CHRONIC DISEASE; DOUBLE-BLIND METHOD; ELECTRIC STIMULATION THERAPY; FEMALE; HUMANS; LEG; LEG ULCER; MALE; MICROCIRCULATION; NERVE FIBERS, UNMYELINATED; REGIONAL BLOOD FLOW; SENSORY RECEPTOR CELLS; STOCKINGS, COMPRESSION; WOUND HEALING;

EID: 77949327227     PISSN: 18746098     EISSN: 18746128     Source Type: Journal    
DOI: 10.2174/1874609810902010072     Document Type: Article

References (37)

1. Australian Bureau of Statistics. Older people, Australia: A social report. Australian Bureau of Statistics (1999).
2. Callam MJ, Ruckley CV, Harper DR and Dale JJ. Chronic ulceration of the leg: extent of the problem and provision of care. Br Med J 290: 1855-1856 (1985).
3. Baker SR, Stacey MC, Jopp-McKay AG, Hoskin SE and Thompson PJ. Epidemiology of chronic venous ulcers. Br J Surg 78: 864-867 (1991).
4. Khalil Z, Ralevic V, Bassirat M, Dusting GJ and Helme RD. Effect of ageing on sensory nerve function in rat skin. Brain Res 641: 265-272 (1994).
5. Baker S and Stacey M. Epidemiology of chronic leg ulcers in Australia. Aust NZ J Surg 64: 258-261 (1994).
6. Richards AM, Mitsou J, Floyd DC, Terenghi G and McGrouther DA. Neural innervation and healing. Lancet 350: 339-340 (1997).
7. Ashcroft GS, Horan MA and Ferguson MW. The effects of ageing on cutaneous wound healing in mammals. J Anat 187: 1- 26 (1995).
8. Ardron M, Helme R and McKernan S. Microvascular skin responses in elderly people with varicose leg ulcers. Age Ageing 20: 124-128 (1991).
9. Fletcher A, Cullum N and Sheldon T. A systematic review of compression treatment for venous leg ulcers. Br J Med 315: 576-580 (1997).
10. Cullum N, Nelson EA, Fletcher AW and Sheldon TA. Compression for venous leg ulcers (Cochrane Review). Cochrane Database Syst Rev 2: CD000265 (2001).
11. Lyon RT, Veith FJ, Bolton L and Machado F. Clinical benchmark for healing of chronic venous ulcers. Venous Ulcer Study Collaborators. Am J Surg 176: 172-175 (1998).
12. Moffatt CJ, Franks PJ, Oldroyd M, Bosanquet N, Brown P, Greenhalgh RM, et al. Community clinics for leg ulcers and impact on healing. Br Med J 305: 1389-1392 (1992).
13. Margolis D, Berlin J and Strom B. Which venous leg ulcers will heal with limb compression bandages? Am J Med 109: 15-19 (2000).
14. Thomson B, Hooper P, Powell R and Warin AP. Four-layer bandaging and healing rates of venous leg ulcers. J Wound Care 5: 213-216 (1996).
15. I, Smith JM, Doré CJ, Charlett A and Lewis JD. Venous leg ulcers - A prognostic index to predict time to healing. Br Med J 205: 1119-1121 (1992).
16. Khalil Z and Helme R. Sensory peptides as neuromodulators of wound healing in aged rats. J Gerontol Biol Sci Med Sci 51: B354-61 (1996).
17. Merhi M. Changes in sensory nerve function with age: relevance to processes of repair, in Medicine. University of Melbourne: Melbourne (1998).
18. Merhi M, Helme R and Khalil Z. Age-related changes in sympathetic modulation of sensory nerve activity in rat skin. Inflamm Res 47: 239-244 (1998).
19. Khalil Z and Merhi M. Effects of aging on neurogenic vasodilator responses evoked by transcutaneous electrical nerve stimulation: Relevance to wound healing. J Gerontol Ser A Biol Sci Med Sci 55: B257-B263 (2000).
20. Khalil Z, Jian L and Helme R. The use of non-invasive transcutaneous and acupuncture electrical stimulation techniques to modulate peripheral microcirculation. Prog Microcirc Res 9: 57-59 (1997).
21. Khalil Z, LeVasseur S, Merhi M and Helme R. Sympathetic modulation of sensory nerve activity with age: human and rodent skin models. Clin Exp Pharmacol Physiol 24: 883-886 (1997).
22. Sanderson K, Nyberg F and Khalil Z. Modulation of sensory nerve function by locally administered hemorphin-7. Inflamm Res 47: 49-55 (1998).
23. Khalil Z, Sanderson K Modig M and Nyberg F. Modulation of peripheral inflammation by locally administered endomorphin-1. Inflamm Res 48: 1-7 (1999).
24. Khalil Z. Sensory peptides: effects in ageing and wound healing. In 'Pain and Neurogenic Inflammation' (Brain S and Moore P, Eds.), Life Sciences/ Birkhauser Verlag, Basel, pp. 275-296 (1999).
25. Padberg FT Jr, Maniker AH, Carmel G, Pappas PJ, Silva MB Jr and Hobson RW 2nd. Sensory impairment: a feature of chronic venous insufficiency. J Vasc Surg, 30: 836-842 9 (1999).
26. Shami SK, Shields DA, Farrah J, Scurr JH and Coleridge Smith PD. Peripheral nerve function in chronic venous insufficiency. Eur J Vasc Surg 7:195-200 (1993).
27. Obeid AN, Barnett NJ, Dougherty G and Ward G. A critical review of laser Doppler flowmetry. J Med Eng Technol 14: 178-181 (1990).
28. Ogrin R, Darzins P and Khalil Z. Age-related changes in microvascular blood flow and transcutaneous oxygen tension under basal and stimulated conditions. J Gerontol Ser A Biol Med Sci 60: 200-206 (2005).
29. Pitei DL, Watkins PJ, Stevens MJ and Edmonds ME. The value of the Neurometer in assessing diabetic neuropathy by measurement of the current perception threshold. Diabet Med 11: 872-6 (1994).
30. Masson EA, Veves A, Fernando D and Boulton AJ. Current perception thresholds: a new, quick, and reproducible method for the assessment of peripheral neuropathy in diabetes mellitus. Diabetologia 32: 724-728 (1989).
31. Dyck, PJ, Karnes J, O'Brien PC and Zimmerman IR. Detection thresholds of cutaneous sensation in humans. In 'Peripheral Neuropathy', (Dyck PJ, Thomas PK, Lambert EH and Bunge R, Eds.), Saunders: Philadelphia. pp. 1103-1038 (1978).
32. Stacey MC, Burnand KG, Layer GT, Pattison M and Browse NL. Measurement of the healing venous ulcer. Aust N Z J Med 61: 844-848 (1991).
33. Belcaro G, Christopoulos A and Nicolaides AN. Diabetic microangiopathy treated with elastic compression--a microcirculatory evaluation using laser-Doppler flowmetry, transcutaneous PO2/PCO2 and capillary permeability measurements. Vasa 19: 247-251 (1990).
34. Fromy B, Abraham P and Saumet JL. Non-nociceptive capsaicin- sensitive nerve terminal stimulation allows for an original vasodilatory reflex in the human skin. Brain Res 811: 166-168 (1998).
35. Taylor A, Taylor R and Marcuson R. Prospective comparison of healing rates and therapy costs for conventional and four-layer high- compression bandaging treatments of venous leg ulcers. Phlebology 13: pp. 20-24 (1998).
36. nd. Transcutaneous Oxygen (TcPO2) estimates probability of healing in the ischemic extremity. J Surg Res 60: 365-369 (1996).
37. Kalani M, Brismar K, Fagrell B, Ostergren J and Jörneskog G. Transcutaneous oxygen tension and toe blood pressure as predictors for outcome of diabetic foot ulcers. Diabetes Care 22: 147-151 (1999).