Expression and prognostic significance of CK19 in canine malignant mammary tumours

Veterinary Journal

Volumn 184, Issue 1, 2010, Pages 45-51

  Gama, Adelina ^a   Alves, Anabela ^a   Schmitt, Fernando ^b,c  

^a UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c University of Porto   (Portugal)

Author keywords

Canine; Cytokeratin 19; Malignant mammary tumours; Prognosis

Indexed keywords

CELL MARKER; CYTOKERATIN 19; ESTROGEN RECEPTOR; KI 67 ANTIGEN;

ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DOG DISEASE; EPITHELIUM CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION; STAINING;

ANIMALS; CELL DIFFERENTIATION; DISEASE-FREE SURVIVAL; DOG DISEASES; DOGS; FEMALE; IMMUNOHISTOCHEMISTRY; KERATIN-19; MAMMARY NEOPLASMS, ANIMAL; PROGNOSIS; RECEPTORS, ESTROGEN; TUMOR MARKERS, BIOLOGICAL;

EID: 77949320914     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2009.02.001     Document Type: Article

References (41)

1. Abd El-Rehim D.M., Pinder S.E., Paish C.E., Bell J., Blamey R.W., Robertson J.F., Nicholson R.I., Ellis I.O. Expression of luminal and basal cytokeratins in human breast carcinoma. Journal of Pathology 2004, 203:661-671.
2. Birnbaum D., Bertucci F., Ginestier C., Tagett R., Jacquemier J., Charafe-Jauffret E. Basal and luminal breast cancers: basic or luminous?. International Journal of Oncology 2004, 25:249-258.
3. Bocker W., Moll R., Poremba C., Holland R., Van Diest P.J., Dervan P., Burger H., Wai D., Ina Diallo R., Brandt B., Herbst H., Schmidt A., Lerch M.M., Buchwallow I.B. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Laboratory Investigation 2002, 82:737-746.
4. Choi I., Gudas L.J., Katzenellenbogen B.S. Regulation of keratin 19 gene expression by estrogen in human breast cancer cells and identification of the estrogen responsive gene region. Molecular and Cellular Endocrinology 2000, 164:225-237.
5. Chu P.G., Weiss L.M. Keratin expression in human tissues and neoplasms. Histopathology 2002, 40:403-439.
6. Destexhe E., Lespagnard L., Degeyter M., Heymann R., Coignoul F. Immunohistochemical identification of myoepithelial, epithelial, and connective tissue cells in canine mammary tumors. Veterinary Pathology 1993, 30:146-154.
7. Elston C.W., Ellis I.O. Assessment of histological grade. The Breast 1998, 365-384. Churchill Livingstone, London, UK. third ed. C.W. Elston, I.O. Ellis (Eds.).
8. Espinosa de Los Monteros A., Millán M.Y., Ordás J., Carrasco L., Reymundo C., Martín de Las Mulas J. Immunolocalization of the smooth muscle-specific protein calponin in complex and mixed tumors of the mammary gland of the dog: assessment of the morphogenetic role of the myoepithelium. Veterinary Pathology 2002, 39:247-256.
9. Ferguson H.R. Canine mammary gland tumors. Veterinary Clinics of North America Small Animal Practice 1985, 15:501-511.
10. Gama A., Alves A., Gartner F., Schmitt F.C. P63: a novel myoepithelial cell marker in canine mammary tissues. Veterinary Pathology 2003, 40:412-420.
11. Gama A., Paredes J., Albergaria A., Gartner F., Schmitt F.C. P-cadherin expression in canine mammary tissues. Journal of Comparative Pathology 2004, 130:13-20.
12. Gama A., Paredes J., Gärtner F., Alves A., Schmitt F.C. Expression of E-cadherin, P-cadherin and β-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival. The Veterinary Journal 2008, 177:45-53.
13. Griffey S.M., Madewell B.R., Dairkee S.H., Hunt J.E., Naydan D.K., Higgins R.J. Immunohistochemical reactivity of basal and luminal epithelium-specific cytokeratin antibodies within normal and neoplastic canine mammary glands. Veterinary Pathology 1993, 30:155-161.
14. Hellmén E., Lindgren A. The expression of intermediate filaments in canine mammary glands and their tumors. Veterinary Pathology 1989, 26:420-428.
15. Malzahn K., Mitze M., Thoenes M., Moll R. Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas. Virchows Archiv 1998, 433:119-129.
16. Misdorp, W., Else, R.W., Hellmén, E., Lipscomb, T.P., 1999. Histological Classification of Mammary Tumors of the Dog and the Cat. 2nd Series, vol VII. Armed Forces Institute of Pathology, American Registry of Pathology, Washington DC, and The World Health Organization Collaborating Center for Worldwide Reference on Comparative Oncology, pp. 1-59.
17. Misdorp W. Tumours of the mammary gland. Tumors in Domestic Animals 2002, 575-606. Iowa State Press, Blackwell Publishing Company. fourth ed. D.J. Meuten (Ed.).
18. Moll R., Franke W.W., Schiller D.L., Geiger B., Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982, 31:11-24.
19. Moulton J.E. Tumors of the mammary gland. Tumors in Domestic Animals 1990, 518-553. University of California Press, Berkeley. third ed. J.E. Moulton (Ed.).
20. Nerurkar V.R., Chitale A.R., Jalnakurpar B.V., Naik S.N., Lalitha V.S. Comparative pathology of canine mammary tumours. Journal of Comparative Pathology 1989, 101:389-397.
21. Nielsen T.O., Hsu F.D., Jensen K., Cheang M., Karaca G., Hu Z., Hernandez-Boussard T., Livasy C., Cowan D., Dressler L., Akslen L.A., Ragaz J., Gown A.M., Gilks C.B., van de Rijn M., Perou C.M. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clinical Cancer Research 2004, 10:5367-5374.
22. Parikh R.R., Yang Q., Higgins S.A., Haffty B.G. Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression. International Journal of Radiation Oncology, Biology, Physics 2008, 70:35-42.
23. Perou C.M., Sorlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., Pollack J.R., Ross D.T., Johnsen H., Akslen L.A., Fluge O., Pergamenschikov A., Williams C., Zhu S.X., Lonning P.E., Borresen-Dale A.L., Brown P.O., Botstein D. Molecular portraits of human breast tumours. Nature 2000, 406:747-752.
24. Rabanal R.M., Else R.W. Immunohistochemical localisation of cytokeratin and vimentin intermediate filament proteins in canine mammary tumours. Research in Veterinary Science 1994, 56:225-233.
25. Rakha E.A., Putti T.C., Abd El-Rehim D.M., Paish C., Green A.R., Powe D.G., Lee A.H., Robertson J.F., Ellis I.O. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation. Journal of Pathology 2006, 208:495-506.
26. Ramalho L.N.Z., Ribeiro-Silva A., Cassali G.D., Zucoloto S. The expression of p63 and cytokeratin 5 in mixed tumors of the canine mammary gland provides new insights into the histogenesis of these neoplasms. Veterinary Pathology 2006, 43:424-429.
27. Romano V., Bosco P., Rocchi M., Costa G., Leube R.E., Franke W.W., Romeo G. Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes. Cytogenetics and Cell Genetics 1988, 48:148-151.
28. Santini D., Ceccarelli C., Taffurelli M., Pileri S., Marrano D. Differentiation pathways in primary invasive breast carcinoma as suggested by intermediate filament and biopathological marker expression. Journal of Pathology 1996, 179:386-391.
29. Sarli, G., Sassi, F., Brunetti, B., Benazzi, C., 2007. Luminal-like A and B types in canine mammary carcinomas. In: 25th Annual Meeting of the European Society for Veterinary Pathology, Munich, Germany, p. 187.
30. Schaller G., Fuchs I., Pritze W., Ebert A., Herbst H., Pantel K., Weitzel H., Lengyel E. Elevated keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer. Clinical Cancer Research 1996, 2:1879-1885.
31. Sorlie, T., Perou, C.M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M.B., Rijn, M.V., Jeffrey, S.S., Thorsen, T., Quist, H., Matese, J.C., Brown, P.O., Botstein, D., Lonning, P.E., Borresen-Dale, A.L., 2001. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. In: Proceedings of the National Academy of Sciences USA 98, pp. 10869-10874.
32. Sorlie, T., Tibshirani, R., Parker, J., Hastie, T., Marron, J.S., Nobel, A., Deng, S., Johnsen, H., Pesich, R., Geisler, S., Demeter, J., Perou, C.M., Lonning, P.E., Brown, P.O., Borresen-Dale, A.L., Botstein, D., 2003. Repeated observation of breast tumor subtypes in independent gene expression data sets. In: Proceedings of the National Academy of Sciences USA 100, pp. 8418-8423.
33. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nature Reviews Cancer 2002, 2:442-454.
34. van de Rijn M., Perou C.M., Tibshirani R., Haas P., Kallioniemi O., Kononen J., Torhorst J., Sauter G., Zuber M., Kochli O.R., Mross F., Dieterich H., Seitz R., Ross D., Botstein D., Brown P. Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome. American Journal of Pathology 2002, 161:1991-1996.
35. Vos J.H., Van den Ingh T.S., Misdorp W., Molenbeek R.F., Van Mil F.N., Rutterman G.R., Ivanyi D., Ramaekers F.C.S. Immunohistochemistry with keratin, vimentin, desmin, and α-smooth muscle actin monoclonal antibodies in canine mammary gland: benign mammary tumors and duct ectasias. Veterinary Quarterly 1993, 14:89-95.
36. Vos J.H., Van den Ingh T.S., Misdorp W., Molenbeek R.F., Van Mil F.N., Rutterman G.R., Ivanyi D., Ramaekers F.C.S. Immunohistochemistry with keratin, vimentin, desmin, and α-smooth muscle actin monoclonal antibodies in canine mammary gland: malignant mammary tumors. Veterinary Quarterly 1993, 14:96-102.
37. Vos J.H., Van den Ingh T.S., Misdorp W., Molenbeek R.F., Van Mil F.N., Rutterman G.R., Ivanyi D., Ramaekers F.C.S. Immunohistochemistry with keratin, vimentin, desmin, and α-smooth muscle actin monoclonal antibodies in canine mammary gland: normal mammary tissue. Veterinary Quarterly 1993, 14:102-107.
38. Willipinski-Stapelfeldt B., Riethdorf S., Assmann V., Woelfle U., Rau T., Sauter G., Heukeshoven J., Pantel K. Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clinical Cancer Research 2005, 11:8006-8014.
39. Woelfle U., Sauter G., Santjer S., Brakenhoff R., Pantel K. Downregulated expression of cytokeratin 18 promotes progression of human breast cancer. Clinical Cancer Research 2004, 10:2670-2674.
40. Zaidan Dagli M.L. The search for suitable prognostic markers for canine mammary tumors: a promising outlook. The Veterinary Journal 2008, 177:3-5.
41. Zajchowski D.A., Bartholdi M.F., Gong Y., Webster L., Liu H.L., Munishkin A., Beauheim C., Harvey S., Ethier S.P., Johnson P.H. Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. Cancer Research 2001, 61:5168-5178.